valproic acid has been researched along with Memory Disorders in 48 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 8.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| "We utilized a valproic acid (VPA) -induced rat model of autism to evaluate the levels of S1P and the expression of sphingosine kinase (SphK), a key enzyme for S1P production, in serum and hippocampal tissue." | 7.88 | Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism. ( Cao, Y; Gao, J; Hao, Y; Sun, C; Wang, J; Wu, H; Wu, L; Xia, W; Zhang, Q, 2018) |
| "Prenatal exposure to valproic acid (VPA) in rat offspring is capable of inducing experimental autism with neurobehavioral aberrations." | 7.83 | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. ( Cao, Y; Gao, J; Liang, S; Sun, H; Wang, H; Wang, X; Wang, Y; Wu, L; Yang, F; Zhang, F, 2016) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 7.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 4.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| " Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
| "We utilized a valproic acid (VPA) -induced rat model of autism to evaluate the levels of S1P and the expression of sphingosine kinase (SphK), a key enzyme for S1P production, in serum and hippocampal tissue." | 3.88 | Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism. ( Cao, Y; Gao, J; Hao, Y; Sun, C; Wang, J; Wu, H; Wu, L; Xia, W; Zhang, Q, 2018) |
| "Prenatal exposure to valproic acid (VPA) in rat offspring is capable of inducing experimental autism with neurobehavioral aberrations." | 3.83 | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. ( Cao, Y; Gao, J; Liang, S; Sun, H; Wang, H; Wang, X; Wang, Y; Wu, L; Yang, F; Zhang, F, 2016) |
| " As we have recently shown, inhibitors of histone deacetylases, in particular, valproic acid (VA), were capable of up-regulating NEP expression and activity in human neuroblastoma SH-SY5Y cell lines characterised by very low levels of NEP." | 3.78 | Effect of sodium valproate administration on brain neprilysin expression and memory in rats. ( Bagrova, DI; Belyaev, ND; Dubrovskaya, NM; Lewis, DI; Makova, NZ; Nalivaeva, NN; Pickles, AR; Plesneva, SA; Turner, AJ; Zhuravin, IA, 2012) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 3.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| "Valproic acid (VPA) was administered intraperitoneally at doses of 500 mg/kg to female rats during gestational 12." | 1.72 | Sumac and gallic acid-loaded nanophytosomes ameliorate hippocampal oxidative stress via regulation of Nrf2/Keap1 pathway in autistic rats. ( Abbasalipour, H; Hajizadeh Moghaddam, A; Ranjbar, M, 2022) |
| "Treatment with valproic acid (VPA) deteriorates hippocampal neurogenesis, which leads to memory impairment." | 1.62 | Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. ( Anosri, T; Aranarochana, A; Kaewngam, S; Pannangrong, W; Sirichoat, A; Welbat, JU; Wigmore, P, 2021) |
| " Chronic administration of valproate seems to have beneficial effects on diabetic neuropathy." | 1.48 | Sodium valproate ameliorates memory impairment and reduces the elevated levels of apoptotic caspases in the hippocampus of diabetic mice. ( Amirpour-Najafabadi, B; Gholami, M; Hosseini, S; Sadegh, M; Zareie, P, 2018) |
| "Sporadic Alzheimer's disease (SAD) is a slowly progressive neurological disorder that is the most common form of dementia." | 1.46 | Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. ( El Sayed, NSED; Sorial, ME, 2017) |
| "Asiatic acid is a triterpenoid derived from the medicinal plant Centella asiatica." | 1.43 | Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival. ( Chaijaroonkhanarak, W; Pakdeechote, P; Pannangrong, W; Prachaney, P; Sirichoat, A; Sripanidkulchai, B; Umka Welbat, J; Wigmore, P, 2016) |
| "VPA-treated rats showed memory deficits, a decrease in the number of proliferating cells in the sub granular zone and decreases in the levels of Notch1 and BDNF but not DCX compared to control animals." | 1.43 | Fluoxetine prevents the memory deficits and reduction in hippocampal cell proliferation caused by valproic acid. ( Chaijaroonkhanarak, W; Chaisawang, P; Pannangrong, W; Prachaney, P; Sangrich, P; Sirichoat, A; Welbat, JU; Wigmore, P, 2016) |
| "Valproic acid (VPA) has been shown to have anti-inflammatory function." | 1.42 | Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer's disease. ( Chen, WL; Hong, LP; Ji, WD; Liu, JH; Long, DH; Pan, XB; Wei, P; Xuan, AG; Zhang, WJ, 2015) |
| "NMD reversed the long-term memory loss induced by PHT and VPA in the PAT." | 1.30 | Effect of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats. ( Balakrishnan, S; Pandhi, P, 1997) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.50) | 18.7374 |
| 1990's | 2 (4.17) | 18.2507 |
| 2000's | 7 (14.58) | 29.6817 |
| 2010's | 26 (54.17) | 24.3611 |
| 2020's | 7 (14.58) | 2.80 |
| Authors | Studies |
|---|---|
| Aranarochana, A | 3 |
| Sirichoat, A | 5 |
| Pannangrong, W | 5 |
| Wigmore, P | 5 |
| Welbat, JU | 4 |
| Kaewngam, S | 1 |
| Anosri, T | 1 |
| Abbasalipour, H | 1 |
| Hajizadeh Moghaddam, A | 1 |
| Ranjbar, M | 1 |
| Taheri, F | 1 |
| Esmaeilpour, K | 1 |
| Sepehri, G | 1 |
| Sheibani, V | 1 |
| Ur Rehman, N | 1 |
| Maneshian, M | 1 |
| Nouri, E | 1 |
| Karimi, SA | 1 |
| Raoufi, S | 1 |
| Zarei, M | 1 |
| Lima-Castañeda, LÁ | 1 |
| Bringas, ME | 1 |
| Aguilar-Hernandez, L | 1 |
| Garcés-Ramírez, L | 1 |
| Morales-Medina, JC | 1 |
| Flores, G | 1 |
| Sharma, NK | 1 |
| Kaur, S | 1 |
| Goel, RK | 2 |
| Wu, H | 2 |
| Zhang, Q | 1 |
| Gao, J | 3 |
| Sun, C | 2 |
| Wang, J | 2 |
| Xia, W | 1 |
| Cao, Y | 3 |
| Hao, Y | 1 |
| Wu, L | 3 |
| Zareie, P | 1 |
| Gholami, M | 1 |
| Amirpour-Najafabadi, B | 1 |
| Hosseini, S | 1 |
| Sadegh, M | 1 |
| Barton, S | 1 |
| Nadebaum, C | 1 |
| Anderson, VA | 1 |
| Vajda, F | 1 |
| Reutens, DC | 1 |
| Wood, AG | 1 |
| Cohen, MJ | 1 |
| Meador, KJ | 1 |
| May, R | 1 |
| Loblein, H | 1 |
| Conrad, T | 1 |
| Baker, GA | 2 |
| Bromley, RL | 1 |
| Clayton-Smith, J | 1 |
| Kalayjian, LA | 1 |
| Kanner, A | 1 |
| Liporace, JD | 1 |
| Pennell, PB | 1 |
| Privitera, M | 1 |
| Loring, DW | 1 |
| Chaisawang, P | 2 |
| Xuan, AG | 1 |
| Pan, XB | 1 |
| Wei, P | 1 |
| Ji, WD | 1 |
| Zhang, WJ | 1 |
| Liu, JH | 1 |
| Hong, LP | 1 |
| Chen, WL | 1 |
| Long, DH | 1 |
| Yao, ZG | 1 |
| Liang, L | 1 |
| Liu, Y | 1 |
| Zhang, L | 1 |
| Zhu, H | 1 |
| Huang, L | 1 |
| Qin, C | 1 |
| Pinheiro, RM | 2 |
| de Lima, MN | 2 |
| Portal, BC | 1 |
| Busato, SB | 1 |
| Falavigna, L | 1 |
| Ferreira, RD | 1 |
| Paz, AC | 1 |
| de Aguiar, BW | 1 |
| Kapczinski, F | 2 |
| Schröder, N | 2 |
| Galer, S | 1 |
| Urbain, C | 1 |
| De Tiège, X | 1 |
| Emeriau, M | 1 |
| Leproult, R | 1 |
| Deliens, G | 1 |
| Nonclerq, A | 1 |
| Peigneux, P | 1 |
| Van Bogaert, P | 1 |
| Sharma, S | 1 |
| Taliyan, R | 1 |
| Mishra, A | 1 |
| Long, ZM | 1 |
| Zhao, L | 1 |
| Jiang, R | 1 |
| Wang, KJ | 1 |
| Luo, SF | 1 |
| Zheng, M | 1 |
| Li, XF | 1 |
| He, GQ | 1 |
| Wang, X | 1 |
| Sun, H | 2 |
| Liang, S | 2 |
| Wang, H | 1 |
| Wang, Y | 1 |
| Yang, F | 1 |
| Zhang, F | 1 |
| Umka Welbat, J | 1 |
| Chaijaroonkhanarak, W | 2 |
| Prachaney, P | 2 |
| Pakdeechote, P | 1 |
| Sripanidkulchai, B | 1 |
| Wang, P | 1 |
| Sangrich, P | 1 |
| Sorial, ME | 1 |
| El Sayed, NSED | 1 |
| Qing, H | 1 |
| He, G | 1 |
| Ly, PT | 1 |
| Fox, CJ | 1 |
| Staufenbiel, M | 1 |
| Cai, F | 1 |
| Zhang, Z | 1 |
| Wei, S | 1 |
| Sun, X | 1 |
| Chen, CH | 1 |
| Zhou, W | 1 |
| Wang, K | 1 |
| Song, W | 1 |
| Frisch, C | 1 |
| Hüsch, K | 1 |
| Angenstein, F | 1 |
| Kudin, A | 1 |
| Kunz, W | 1 |
| Elger, CE | 1 |
| Helmstaedter, C | 1 |
| España, J | 1 |
| Giménez-Llort, L | 1 |
| Valero, J | 1 |
| Miñano, A | 1 |
| Rábano, A | 1 |
| Rodriguez-Alvarez, J | 1 |
| LaFerla, FM | 1 |
| Saura, CA | 1 |
| Umka, J | 1 |
| Mustafa, S | 1 |
| ElBeltagy, M | 1 |
| Thorpe, A | 1 |
| Latif, L | 1 |
| Bennett, G | 1 |
| Wigmore, PM | 1 |
| Sgobio, C | 1 |
| Ghiglieri, V | 1 |
| Costa, C | 1 |
| Bagetta, V | 1 |
| Siliquini, S | 1 |
| Barone, I | 1 |
| Di Filippo, M | 1 |
| Gardoni, F | 1 |
| Gundelfinger, ED | 1 |
| Di Luca, M | 1 |
| Picconi, B | 1 |
| Calabresi, P | 1 |
| Hessen, E | 1 |
| Lossius, MI | 1 |
| Gjerstad, L | 1 |
| Nalivaeva, NN | 1 |
| Belyaev, ND | 1 |
| Lewis, DI | 1 |
| Pickles, AR | 1 |
| Makova, NZ | 1 |
| Bagrova, DI | 1 |
| Dubrovskaya, NM | 1 |
| Plesneva, SA | 1 |
| Zhuravin, IA | 1 |
| Turner, AJ | 1 |
| Fries, GR | 1 |
| Garcia, VA | 1 |
| Presti-Torres, J | 1 |
| Hallmenschlager, LH | 1 |
| Alcalde, LA | 1 |
| Roesler, R | 1 |
| Andersen, ML | 1 |
| Quevedo, J | 2 |
| Castro, AA | 1 |
| Ghisoni, K | 1 |
| Latini, A | 1 |
| Tasca, CI | 1 |
| Prediger, RD | 1 |
| Conde-Guzon, PA | 1 |
| Cancho-Candela, R | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| Borowicz, KK | 1 |
| Zadrozniak, M | 1 |
| Swiader, M | 1 |
| Kowalska, A | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Foley, AG | 1 |
| Gallagher, HC | 1 |
| Murphy, KJ | 1 |
| Regan, CM | 1 |
| Martínez-Arán, A | 1 |
| Vieta, E | 1 |
| Colom, F | 1 |
| Torrent, C | 1 |
| Sánchez-Moreno, J | 1 |
| Reinares, M | 1 |
| Benabarre, A | 1 |
| Goikolea, JM | 1 |
| Brugué, E | 1 |
| Daban, C | 1 |
| Salamero, M | 1 |
| Vinten, J | 1 |
| Adab, N | 1 |
| Kini, U | 1 |
| Gorry, J | 1 |
| Gregg, J | 1 |
| Mondadori, C | 1 |
| Schmutz, M | 1 |
| Baltzer, V | 1 |
| Butlin, AT | 2 |
| Danta, G | 2 |
| Cook, ML | 2 |
| Aldenkamp, AP | 1 |
| Alpherts, WC | 1 |
| Blennow, G | 1 |
| Elmqvist, D | 1 |
| Heijbel, J | 1 |
| Nilsson, HL | 1 |
| Sandstedt, P | 1 |
| Tonnby, B | 1 |
| Wåhlander, L | 1 |
| Wosse, E | 1 |
| Balakrishnan, S | 1 |
| Pandhi, P | 1 |
| Wu, Y | 1 |
| Wang, L | 1 |
| Pedersen, B | 1 |
| Dam, M | 1 |
| Trimble, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating the Effect of Closed-loop Auditory Stimulation on Sleep and Behavior in Patients With Epilepsy and Healthy Controls: a Developmental Study[NCT04716673] | 120 participants (Anticipated) | Interventional | 2020-07-29 | Recruiting | |||
| Changes in Serum miRNA and BDNF Levels in Bipolar II Depression Treated by Theta-burst Stimulation: A Randomized Sham-controlled Exploratory Study[NCT04998097] | 60 participants (Anticipated) | Interventional | 2022-05-23 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for valproic acid and Memory Disorders
| Article | Year |
|---|---|
Improvement in verbal memory after withdrawal of carbamazepine and valproate in patients with well-controlled epilepsy: a randomized, double-blind study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Female; Humans; Male; | 2011 |
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie | 1993 |
46 other studies available for valproic acid and Memory Disorders
| Article | Year |
|---|---|
Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats.
Topics: Animals; Anticonvulsants; Antioxidants; Hippocampus; Male; Melatonin; Memory Disorders; Neurogenesis | 2021 |
Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Doublecortin Do | 2021 |
Sumac and gallic acid-loaded nanophytosomes ameliorate hippocampal oxidative stress via regulation of Nrf2/Keap1 pathway in autistic rats.
Topics: Animals; Antioxidants; Autistic Disorder; Female; Gallic Acid; Glutathione; Glutathione Peroxidase; | 2022 |
Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cognition; Disease Models, Animal; Female; His | 2022 |
Protective effects of L-carnitine against valproic acid-induced memory impairment and anxiety-like behavior in adult rat.
Topics: Animals; Anxiety; Carnitine; Male; Maze Learning; Memory Disorders; Rats; Rats, Wistar; Valproic Aci | 2022 |
The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism.
Topics: Animals; Antipsychotic Agents; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Diseas | 2023 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.
Topics: Analysis of Variance; Animals; Apoptosis; Autistic Disorder; Autophagy; Biomarkers; Disease Models, | 2018 |
Sodium valproate ameliorates memory impairment and reduces the elevated levels of apoptotic caspases in the hippocampus of diabetic mice.
Topics: Animals; Apoptosis; Caspases; Diabetes Mellitus, Experimental; Hippocampus; Male; Maze Learning; Mem | 2018 |
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Hu | 2018 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Hippocampus; Male; Melatonin; Memory Disorders; Neural S | 2019 |
Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Death; Cytokines; Histone | 2015 |
Valproate improves memory deficits in an Alzheimer's disease mouse model: investigation of possible mechanisms of action.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Memory; Memory D | 2014 |
Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cytokines; Exploratory Behavior; Fructose; Hippocampus; | 2015 |
Impaired sleep-related consolidation of declarative memories in idiopathic focal epilepsies of childhood.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Epilepsy, Rolandic; Female; Hum | 2015 |
Synergistic effects of GSK-3β and HDAC inhibitors in intracerebroventricular streptozotocin-induced cognitive deficits in rats.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Brain-Derived Neurotrophic Factor; Cogniti | 2015 |
Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Epilepsy | 2015 |
Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cells, Cultured; Enzyme Inhibitor | 2015 |
Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model.
Topics: Animals; Anticonvulsants; Autistic Disorder; Caspase 3; Cell Death; Disease Models, Animal; Docosahe | 2016 |
Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival.
Topics: Animals; Anticonvulsants; Cell Proliferation; Cell Survival; Cognition; Dentate Gyrus; Immunohistoch | 2016 |
Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; CA1 Region, Hippocampal; Dietary Supplements; Docosahexa | 2016 |
Fluoxetine prevents the memory deficits and reduction in hippocampal cell proliferation caused by valproic acid.
Topics: Animals; Cell Proliferation; Doublecortin Protein; Fluoxetine; Hippocampus; Male; Memory Disorders; | 2016 |
Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diseas | 2017 |
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2008 |
Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat.
Topics: Abnormalities, Drug-Induced; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvu | 2009 |
Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Amyloid beta-Protein Pr | 2010 |
Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.
Topics: Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cognition; Cognitio | 2010 |
Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biophysics; Calcium-Calmodulin-Dependent Protein Kinase | 2010 |
Effect of sodium valproate administration on brain neprilysin expression and memory in rats.
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cell Line, Tumor; Disease Models, Animal; Female; Human | 2012 |
Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Body Weight; Central Nervous System S | 2012 |
Lithium and valproate prevent olfactory discrimination and short-term memory impairments in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rat model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Age Factors; Animals; Anim | 2012 |
[Idiopathic generalized epilepsies with absence seizures with valproic acid treatment: neuropsychological disorders].
Topics: Anticonvulsants; Attention; Child; Comprehension; Epilepsy, Absence; Female; Hearing Loss, Central; | 2012 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
Topics: Aminophylline; Amygdala; Anesthetics; Animals; Anticonvulsants; Avoidance Learning; Convulsants; Dru | 2002 |
Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Male; Memory Disorders; Rats; Rats, Wistar; Reacti | 2004 |
Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Dysthymic Disorde | 2004 |
Neuropsychological effects of exposure to anticonvulsant medication in utero.
Topics: Adolescent; Anticonvulsants; Brain; Child; Cognition Disorders; Cohort Studies; Epilepsy; Female; Hu | 2005 |
Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Synergis | 1984 |
Anticonvulsant effects on the memory performance of epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Intelligence; Memory; Memory Di | 1984 |
Anticonvulsants, folic acid and memory dysfunction in epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memor | 1984 |
Effect of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats.
Topics: Animals; Avoidance Learning; Female; Male; Memory Disorders; Nimodipine; Phenytoin; Rats; Retention, | 1997 |
The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C gamma in immature rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Carbamazepine; Hippocampus; Immunohistochemistry; Isoen | 2002 |
Memory disturbances in epileptic patients.
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenytoin; Valproic Ac | 1986 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
American Academy of Pediatrics. Behavioral and cognitive effects of anticonvulsant therapy. Committee on Drugs.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Child; Child Behavior Disorders; Clonazepam; Cogni | 1985 |