valproic acid has been researched along with Medulloblastoma in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 7.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
| "To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 7.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
| "Valproic acid is a well-tolerated anticonvulsant that has been identified recently as a histone deacetylase inhibitor." | 5.33 | Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. ( Blaney, SM; Lau, CC; Li, XN; Perlaky, L; Shu, Q; Su, JM, 2005) |
| "Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 3.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
| " The authors evaluated the cytotoxicity of histone deacetylase inhibitors (HDI) [MS-275, SAHA, TSA, M344, M360, D85, SW55, SW187 and valproic acid (VPA)] on 13 embryonal tumor cell lines [4 medulloblastomas, 5 neuroblastomas, 2 atypical teratoid/rhabdoid tumors (AT/RT), and 2 malignant rhabdoid tumors of the kidney (RTK)] in MTT assay." | 3.74 | Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. ( Frühwald, MC; Furchert, SE; Jung, M; Juürgens, H; Lanvers-Kaminsky, C; Loidl, A, 2007) |
| "To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 3.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
| "Medulloblastoma is the most common malignant brain tumor in children." | 1.43 | Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition. ( Abrari, A; Gupta, A; Kumar, A; Patir, R; Vaishya, S, 2016) |
| "Valproic acid is a well-tolerated anticonvulsant that has been identified recently as a histone deacetylase inhibitor." | 1.33 | Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. ( Blaney, SM; Lau, CC; Li, XN; Perlaky, L; Shu, Q; Su, JM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mascaro-Cordeiro, B | 1 |
| Oliveira, ID | 1 |
| Tesser-Gamba, F | 1 |
| Pavon, LF | 1 |
| Saba-Silva, N | 1 |
| Cavalheiro, S | 1 |
| Dastoli, P | 1 |
| Toledo, SRC | 1 |
| Patties, I | 2 |
| Kortmann, RD | 2 |
| Glasow, A | 2 |
| Menzel, F | 1 |
| Gupta, A | 1 |
| Kumar, A | 1 |
| Abrari, A | 1 |
| Patir, R | 1 |
| Vaishya, S | 1 |
| Ecke, I | 1 |
| Petry, F | 1 |
| Rosenberger, A | 1 |
| Tauber, S | 1 |
| Mönkemeyer, S | 1 |
| Hess, I | 1 |
| Dullin, C | 1 |
| Kimmina, S | 1 |
| Pirngruber, J | 1 |
| Johnsen, SA | 1 |
| Uhmann, A | 1 |
| Nitzki, F | 1 |
| Wojnowski, L | 1 |
| Schulz-Schaeffer, W | 1 |
| Witt, O | 1 |
| Hahn, H | 1 |
| Häcker, S | 1 |
| Dittrich, A | 1 |
| Mohr, A | 1 |
| Schweitzer, T | 1 |
| Rutkowski, S | 1 |
| Krauss, J | 1 |
| Debatin, KM | 1 |
| Fulda, S | 1 |
| Li, XN | 2 |
| Shu, Q | 2 |
| Su, JM | 2 |
| Perlaky, L | 1 |
| Blaney, SM | 2 |
| Lau, CC | 2 |
| Antalffy, B | 1 |
| Adesina, A | 1 |
| Ou, CN | 1 |
| Pietsch, T | 1 |
| Furchert, SE | 1 |
| Lanvers-Kaminsky, C | 1 |
| Juürgens, H | 1 |
| Jung, M | 1 |
| Loidl, A | 1 |
| Frühwald, MC | 1 |
9 other studies available for valproic acid and Medulloblastoma
| Article | Year |
|---|---|
Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.
Topics: Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Genetic Var | 2018 |
Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Deci | 2013 |
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Di | 2016 |
Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child; Child, Pre | 2016 |
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
Topics: Acetylation; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA ( | 2009 |
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Topics: Benzamides; Caspase 8; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Drug Combinations; Dru | 2009 |
Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cel | 2005 |
Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts.
Topics: Animals; Carcinogenicity Tests; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2006 |
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood.
Topics: Acetylation; Annexin A5; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Enzyme Inh | 2007 |