valproic acid has been researched along with MS (Multiple Sclerosis) in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 8.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| "We present a case of a patient with multiple sclerosis who was treated with plasmapheresis and valproic acid." | 7.79 | Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis. ( Bastiaans, DE; de Jong, BA; Ruiterkamp, RA; van Uden, IW, 2013) |
| " Here in this study, we found significant demyelination in the hippocampus of the mouse cuprizone model, which is accompanied by reduced cholesterol biosynthesis and increased anxiety-like behavior." | 4.02 | Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. ( Gan, G; He, Y; Hu, Y; Liu, X; Yang, J; Yao, Y; Zhang, A; Zhang, C; Zhu, X, 2021) |
| "We present a case of a patient with multiple sclerosis who was treated with plasmapheresis and valproic acid." | 3.79 | Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis. ( Bastiaans, DE; de Jong, BA; Ruiterkamp, RA; van Uden, IW, 2013) |
| "In order to produce this demyelination model, LPC (1%, 2 μL) was injected into the rat optic chiasm." | 1.51 | Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm. ( Ghasemi-Kasman, M; Hashemian, M; Parsian, H; Sadeghi, F, 2019) |
| "Multiple sclerosis is a demyelinating disease with severe neurological symptoms due to blockage of signal conduction in affected axons." | 1.43 | Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. ( Dehghan, S; Fathollahi, Y; Hesaraki, M; Javan, M; Mirnajafi-Zadeh, J; Soleimani, M, 2016) |
| "A 27-year-old woman was diagnosed with juvenile myoclonic epilepsy since the age of 13 and was on valproate therapy." | 1.40 | Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate? ( Acharya, M; Kumawat, BL; Parekh, J; Sharma, C, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, X | 1 |
| Yao, Y | 1 |
| Hu, Y | 1 |
| Yang, J | 1 |
| Zhang, C | 2 |
| He, Y | 1 |
| Zhang, A | 1 |
| Liu, X | 1 |
| Gan, G | 1 |
| Maghbooli, M | 2 |
| Jourahmad, Z | 2 |
| Golizadeh, M | 2 |
| Hashemian, M | 1 |
| Ghasemi-Kasman, M | 1 |
| Parsian, H | 1 |
| Sadeghi, F | 1 |
| Johnson, B | 1 |
| Nichols, S | 1 |
| Sharma, C | 1 |
| Parekh, J | 1 |
| Kumawat, BL | 1 |
| Acharya, M | 1 |
| Nielsen, NM | 1 |
| Svanström, H | 1 |
| Stenager, E | 1 |
| Magyari, M | 1 |
| Koch-Henriksen, N | 1 |
| Pasternak, B | 1 |
| Hviid, A | 1 |
| Anderson, G | 1 |
| Rodriguez, M | 1 |
| Dehghan, S | 1 |
| Hesaraki, M | 1 |
| Soleimani, M | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Fathollahi, Y | 1 |
| Javan, M | 1 |
| Azuchi, Y | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Akiyama, G | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Nishigaki, A | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Bittner, S | 1 |
| Höhn, K | 1 |
| Göbel, K | 1 |
| Kleinschnitz, C | 1 |
| Wiendl, H | 1 |
| Meuth, SG | 1 |
| Chabwine, JN | 1 |
| Rossetti, AR | 1 |
| Hirt, L | 1 |
| Kuntzer, T | 1 |
| Schluep, M | 1 |
| Michel, P | 1 |
| Démonet, JF | 1 |
| du Pasquier, RA | 1 |
| Vingerhoets, FG | 1 |
| Lv, J | 1 |
| Du, C | 1 |
| Wei, W | 1 |
| Wu, Z | 1 |
| Zhao, G | 1 |
| Li, Z | 1 |
| Xie, X | 1 |
| Bastiaans, DE | 1 |
| van Uden, IW | 1 |
| Ruiterkamp, RA | 1 |
| de Jong, BA | 1 |
| Lopez-Meza, E | 1 |
| Corona-Vazquez, T | 1 |
| Ruano-Calderon, LA | 1 |
| Ramirez-Bermudez, J | 1 |
| Stip, E | 1 |
| Daoust, L | 1 |
| Marazziti, D | 1 |
| Cassano, GB | 1 |
| Jacome, DE | 1 |
4 reviews available for valproic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Crying and suicidal, but not depressed. Pseudobulbar affect in multiple sclerosis successfully treated with valproic acid: Case report and literature review.
Topics: Crying; Female; Humans; Middle Aged; Multiple Sclerosis; Pseudobulbar Palsy; Suicidal Ideation; Valp | 2015 |
Multiple sclerosis: the role of melatonin and N-acetylserotonin.
Topics: Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Immunologic Factors; Immunosuppressive Agents; | 2015 |
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohor | 2011 |
1 trial available for valproic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis.
Topics: Animals; Anticonvulsants; Caspase 3; Caspase 8; Drug Evaluation, Preclinical; Encephalomyelitis, Aut | 2012 |
12 other studies available for valproic acid and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis.
Topics: Animals; Anxiety; Cholesterol; Cuprizone; Demyelinating Diseases; Hippocampus; Male; Mice; Mice, Inb | 2021 |
Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Fingolimod Hydrochloride; Histone Deacetyla | 2019 |
Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate?
Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; | 2014 |
The use of valproic acid and multiple sclerosis.
Topics: Adolescent; Adult; Cohort Studies; Denmark; Female; Histone Deacetylase Inhibitors; Humans; Male; Mi | 2015 |
Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.
Topics: Animals; Cell Differentiation; Cell Transdifferentiation; Demyelinating Diseases; Male; Mice, Inbred | 2016 |
Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; MAP Kinase Kin | 2017 |
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai | 2012 |
Removal of valproic acid by plasmapheresis in a patient treated for multiple sclerosis.
Topics: Anticonvulsants; Drug Monitoring; Humans; Male; Middle Aged; Multiple Sclerosis; Plasmapheresis; Val | 2013 |
Severe impulsiveness as the primary manifestation of multiple sclerosis in a young female.
Topics: Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Child; Clozapine; Female; Homicide; Human | 2005 |
Valproate in the treatment of mood disorder due to multiple sclerosis.
Topics: Adult; Female; Humans; Male; Middle Aged; Mood Disorders; Multiple Sclerosis; Valproic Acid | 1995 |
Valproic acid for panic disorder associated with multiple sclerosis.
Topics: Adult; Female; Humans; Multiple Sclerosis; Panic Disorder; Treatment Outcome; Valproic Acid | 1996 |
La toux diabolique: neurogenic tussive crisis.
Topics: Carbamazepine; Cough; Female; Humans; Middle Aged; Multiple Sclerosis; Valproic Acid | 1985 |