valproic acid has been researched along with MODS in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two children developed multiorgan dysfunction with disseminated intravascular coagulation 9 days after lamotrigine was added to their antiepileptic therapy, which included valproic acid." | 7.69 | Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid. ( Chattergoon, DS; Hwang, P; Ito, S; Koren, G; McGuigan, MA, 1997) |
| "We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy." | 3.75 | Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009) |
| "Two children developed multiorgan dysfunction with disseminated intravascular coagulation 9 days after lamotrigine was added to their antiepileptic therapy, which included valproic acid." | 3.69 | Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid. ( Chattergoon, DS; Hwang, P; Ito, S; Koren, G; McGuigan, MA, 1997) |
| "He experienced convulsions from day 4 and was administered anticonvulsants." | 1.37 | [Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report]. ( Hagioka, S; Maeyama, H; Morimoto, N; Nagae, M; Naito, H; Okada, D; Okahara, S, 2011) |
| "Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis." | 1.30 | Multiorgan system failure caused by valproic acid toxicity. ( Pinkston, R; Walker, LA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Myers, KA | 1 |
| Tamon, U | 1 |
| Agnihotram, RV | 1 |
| Berrahmoune, S | 1 |
| Yaman, A | 1 |
| Kendirli, T | 1 |
| Odek, C | 1 |
| Bektaş, O | 1 |
| Kuloğlu, Z | 1 |
| Koloğlu, M | 1 |
| Ince, E | 1 |
| Deda, G | 1 |
| Ferguson, LP | 1 |
| Dargan, PI | 1 |
| Hood, JL | 1 |
| Tibby, SM | 1 |
| Dreesman, A | 1 |
| Hoorens, A | 1 |
| Hachimi-Idrissi, S | 1 |
| Shang, Y | 1 |
| Jiang, YX | 1 |
| Ding, ZJ | 1 |
| Shen, AL | 1 |
| Xu, SP | 1 |
| Yuan, SY | 1 |
| Yao, SL | 1 |
| Naito, H | 1 |
| Nagae, M | 1 |
| Okahara, S | 1 |
| Maeyama, H | 1 |
| Okada, D | 1 |
| Hagioka, S | 1 |
| Morimoto, N | 1 |
| Bowen, DJ | 1 |
| Lucas, NL | 1 |
| Braude, S | 1 |
| Pinkston, R | 1 |
| Walker, LA | 1 |
| Chattergoon, DS | 1 |
| McGuigan, MA | 1 |
| Koren, G | 1 |
| Hwang, P | 1 |
| Ito, S | 1 |
1 review available for valproic acid and MODS
| Article | Year |
|---|---|
Valproic acid-induced acute pancreatitis and multiorgan failure in a child.
Topics: Abdominal Pain; Acute Disease; Anticonvulsants; Child; Delayed Diagnosis; Diagnostic Errors; Dissemi | 2013 |
8 other studies available for valproic acid and MODS
| Article | Year |
|---|---|
Serum Levels of Valproic Acid and Carbamazepine Do Not Correlate Well with End-Organ Dysfunction.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Drug Therapy, | 2020 |
Life-threatening organ failure after lamotrigine therapy.
Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma | 2009 |
Multiple organ dysfunction syndrome: infection or hypersensitivity reaction?
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Hypersensitivity, | 2010 |
Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Lung Injury | 2010 |
[Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report].
Topics: Acetamides; Anticonvulsants; Clonazepam; Gastric Lavage; Herbicides; Humans; Male; Middle Aged; Mult | 2011 |
Persistent febrile illness with multisystem organ failure associated with clozapine.
Topics: Abdominal Pain; Adult; Antipsychotic Agents; Clozapine; Combined Modality Therapy; Diagnostic Errors | 2012 |
Multiorgan system failure caused by valproic acid toxicity.
Topics: Acute Kidney Injury; Anticonvulsants; Emergencies; Humans; Liver Failure; Male; Middle Aged; Migrain | 1997 |
Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid.
Topics: Anticonvulsants; Child; Child, Preschool; Disseminated Intravascular Coagulation; Drug Interactions; | 1997 |