valproic acid has been researched along with MELAS in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 5.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| "To provide the reader with a better understanding of MELAS and the adverse effects of valproic acid." | 3.78 | Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report. ( Hsu, CH; Hsu, YC; Perng, CL; Tso, AC; Wong, LJ; Yang, FC, 2012) |
| "We reported a case of MELAS that presented right distal internal carotid arterial (ICA) stenosis and reviewed 12 similar previously reported cases involving intracranial large blood vessels." | 1.48 | MELAS and macroangiopathy: A case report and literature review. ( Fu, H; Jiang, G; Ju, X; Sun, X, 2018) |
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 1.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, X | 1 |
| Jiang, G | 1 |
| Ju, X | 1 |
| Fu, H | 1 |
| Hsu, YC | 1 |
| Yang, FC | 1 |
| Perng, CL | 1 |
| Tso, AC | 1 |
| Wong, LJ | 2 |
| Hsu, CH | 1 |
| Oppenheim, C | 1 |
| Touzé, E | 1 |
| Meder, JF | 1 |
| Kaplan, PW | 1 |
| Lin, CM | 1 |
| Thajeb, P | 1 |
| Lam, CW | 1 |
| Lau, CH | 1 |
| Williams, JC | 1 |
| Chan, YW | 1 |
6 other studies available for valproic acid and MELAS
| Article | Year |
|---|---|
MELAS and macroangiopathy: A case report and literature review.
Topics: Acidosis, Lactic; Adult; Arginine; Ascorbic Acid; Carotid Stenosis; Humans; Male; MELAS Syndrome; Mi | 2018 |
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report.
Topics: Anticonvulsants; Diagnosis, Differential; DNA, Mitochondrial; Humans; Male; MELAS Syndrome; Meningoe | 2012 |
[Case no 3. MELAS syndrome].
Topics: Adolescent; Diagnosis, Differential; GABA Agents; Headache; Humans; Magnetic Resonance Imaging; Male | 2003 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Electroencephalography; Humans; Liver Failure; MELAS Syndrome; Prognosis; Retrospec | 2003 |
Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA.
Topics: Adult; Anticonvulsants; DNA, Mitochondrial; Electroencephalography; Epilepsy; Humans; Magnetic Reson | 2007 |
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy.
Topics: Anticonvulsants; Child; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Male; MELAS Syndr | 1997 |