valproic acid has been researched along with MELAS Syndrome in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 5.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| "To provide the reader with a better understanding of MELAS and the adverse effects of valproic acid." | 3.78 | Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report. ( Hsu, CH; Hsu, YC; Perng, CL; Tso, AC; Wong, LJ; Yang, FC, 2012) |
| "We reported a case of MELAS that presented right distal internal carotid arterial (ICA) stenosis and reviewed 12 similar previously reported cases involving intracranial large blood vessels." | 1.48 | MELAS and macroangiopathy: A case report and literature review. ( Fu, H; Jiang, G; Ju, X; Sun, X, 2018) |
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 1.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, X | 1 |
| Jiang, G | 1 |
| Ju, X | 1 |
| Fu, H | 1 |
| Hsu, YC | 1 |
| Yang, FC | 1 |
| Perng, CL | 1 |
| Tso, AC | 1 |
| Wong, LJ | 2 |
| Hsu, CH | 1 |
| Oppenheim, C | 1 |
| Touzé, E | 1 |
| Meder, JF | 1 |
| Kaplan, PW | 1 |
| Lin, CM | 1 |
| Thajeb, P | 1 |
| Lam, CW | 1 |
| Lau, CH | 1 |
| Williams, JC | 1 |
| Chan, YW | 1 |
6 other studies available for valproic acid and MELAS Syndrome
| Article | Year |
|---|---|
MELAS and macroangiopathy: A case report and literature review.
Topics: Acidosis, Lactic; Adult; Arginine; Ascorbic Acid; Carotid Stenosis; Humans; Male; MELAS Syndrome; Mi | 2018 |
Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presenting as acute meningoencephalitis: a case report.
Topics: Anticonvulsants; Diagnosis, Differential; DNA, Mitochondrial; Humans; Male; MELAS Syndrome; Meningoe | 2012 |
[Case no 3. MELAS syndrome].
Topics: Adolescent; Diagnosis, Differential; GABA Agents; Headache; Humans; Magnetic Resonance Imaging; Male | 2003 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Electroencephalography; Humans; Liver Failure; MELAS Syndrome; Prognosis; Retrospec | 2003 |
Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA.
Topics: Adult; Anticonvulsants; DNA, Mitochondrial; Electroencephalography; Epilepsy; Humans; Magnetic Reson | 2007 |
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy.
Topics: Anticonvulsants; Child; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Male; MELAS Syndr | 1997 |