valproic acid has been researched along with Low Bone Density in 13 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism." | 7.71 | Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001) |
| " Reported is a 16-year-old man with intractable epilepsy and an 11-year history of chronic hyponatraemia (126-135 mEq/L) due to valproic acid induced syndrome of inappropriate antidiuresis who sustained low-impact fragility fractures and had evidence of osteopaenia on both X-ray and dual energy X-ray absorptiometry (DEXA)." | 3.91 | Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male. ( Ayus, JC; Moritz, ML; Patel, M, 2019) |
| " We previously reported biochemical evidence of increased bone turnover in premenopausal women with epilepsy on phenytoin monotherapy compared with those on carbamazepine, lamotrigine, and valproate." | 3.74 | Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. ( McMahon, DJ; Morrell, MJ; Pack, AM; Randall, A; Shane, E, 2008) |
| "To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism." | 3.71 | Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001) |
| "Valproic acid (VPA) is a broad-spectrum antiepileptic drug, which is widely used as a first line treatment for idiopathic and symptomatic generalized epilepsy, as well as in non-epileptic psychiatric disorders in adult and pediatric patients." | 2.55 | The effect of VPA on bone: From clinical studies to cell cultures-The molecular mechanisms revisited. ( Pitetzis, DA; Spilioti, MG; Yavropoulou, MP; Yovos, JG, 2017) |
| "For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0." | 1.40 | Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014) |
| "We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy." | 1.36 | Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. ( Antoniou, A; Armeni, E; Boufidou, F; Evangelopoulos, EM; Lambrinoudaki, I; Triantafyllou, N; Tsivgoulis, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pitetzis, DA | 1 |
| Spilioti, MG | 1 |
| Yovos, JG | 1 |
| Yavropoulou, MP | 1 |
| Patel, M | 1 |
| Ayus, JC | 1 |
| Moritz, ML | 1 |
| Baek, JH | 1 |
| Seo, YH | 1 |
| Kim, GH | 1 |
| Kim, MK | 1 |
| Eun, BL | 1 |
| Merschin, D | 1 |
| Kerling, F | 1 |
| Winterholler, M | 1 |
| Stangl, R | 1 |
| Triantafyllou, N | 1 |
| Lambrinoudaki, I | 1 |
| Armeni, E | 1 |
| Evangelopoulos, EM | 1 |
| Boufidou, F | 1 |
| Antoniou, A | 1 |
| Tsivgoulis, G | 1 |
| Fuller, HR | 1 |
| Man, NT | 1 |
| Lam, le T | 1 |
| Shamanin, VA | 1 |
| Androphy, EJ | 1 |
| Morris, GE | 1 |
| McGuire, JM | 1 |
| Baram, V | 1 |
| Asher, JM | 1 |
| Oner, N | 1 |
| Kaya, M | 1 |
| Karasalihoğlu, S | 1 |
| Karaca, H | 1 |
| Celtik, C | 1 |
| Tütüncüler, F | 1 |
| Kim, SH | 1 |
| Lee, JW | 1 |
| Choi, KG | 1 |
| Chung, HW | 1 |
| Lee, HW | 1 |
| Pack, AM | 1 |
| Morrell, MJ | 1 |
| Randall, A | 1 |
| McMahon, DJ | 1 |
| Shane, E | 1 |
| Guo, CY | 1 |
| Ronen, GM | 1 |
| Atkinson, SA | 1 |
| Tsukahara, H | 1 |
| Kimura, K | 1 |
| Todoroki, Y | 1 |
| Ohshima, Y | 1 |
| Hiraoka, M | 1 |
| Shigematsu, Y | 1 |
| Tsukahara, Y | 1 |
| Miura, M | 1 |
| Mayumi, M | 1 |
| Takeno, Y | 1 |
1 review available for valproic acid and Low Bone Density
| Article | Year |
|---|---|
The effect of VPA on bone: From clinical studies to cell cultures-The molecular mechanisms revisited.
Topics: Animals; Anticonvulsants; Bone and Bones; Bone Diseases, Metabolic; Cells, Cultured; Humans; Valproi | 2017 |
1 trial available for valproic acid and Low Bone Density
| Article | Year |
|---|---|
Bone mineral metabolism changes in epileptic children receiving valproic acid.
Topics: Absorptiometry, Photon; Adolescent; Alkaline Phosphatase; Anticonvulsants; Bone Density; Bone Diseas | 2004 |
11 other studies available for valproic acid and Low Bone Density
| Article | Year |
|---|---|
Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male.
Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Epileps | 2019 |
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr | 2014 |
[Epilepsy and transverse sternum fractures: sternum fractures in drug-induced osteopenia].
Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Bone Plates; Epilepsy; Female; Fracture Fixation, | 2014 |
Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.
Topics: Absorptiometry, Photon; Adult; Anticonvulsants; Biomarkers; Bone and Bones; Bone Density; Bone Disea | 2010 |
Valproate and bone loss: iTRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells.
Topics: Bone Diseases, Metabolic; Chromatography, Liquid; Collagen; Electrophoresis, Polyacrylamide Gel; Fib | 2010 |
Osteopenia associated with divalproex sodium.
Topics: Adult; Bone Diseases, Metabolic; Humans; Male; Valproic Acid | 2004 |
A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabolic; Calcitriol; | 2007 |
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, M | 2008 |
Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Bone and Bones; Bone Density; Bone Diseases, Developmental; Bone Diseas | 2001 |
Bone mineral status in ambulatory pediatric patients on long-term anti-epileptic drug therapy.
Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabo | 2002 |
[Evaluation of bone atrophy by microdensitometry and effect of active vitamin D3 (1 alpha-OH-D3) administration in patients receiving anticonvulsants].
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Anticonvulsants; Atrophy; Bone and Bones; Bone Dens | 1989 |