valproic acid has been researched along with Liver Failure, Acute in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alpers syndrome was not clearly defined until the link between brain and liver disease was described." | 2.43 | Alpers syndrome: progressive neuronal degeneration of children with liver disease. ( Gordon, N, 2006) |
| "He developed coma and acute liver failure that were attributed to VPA toxicity, and underwent emergency orthotopic liver transplantation (OLTx)." | 1.31 | Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure. ( Camboulives, J; Delarue, A; Guys, JM; Lethel, V; Montfort, MF; Paut, O; Pellissier, JF; Roquelaure, B; Sarles, J, 2000) |
| "We report 2 siblings with Alpers disease who were discordant for exposure to valproate (VPA)." | 1.30 | Valproate-induced liver failure in one of two siblings with Alpers disease. ( Armstrong, DL; Burke, B; Dobyns, WB; Schwabe, MJ, 1997) |
| "A 29-year-old female patient with Friedreich's ataxia and partial seizures with acute liver failure during VPA treatment is reported." | 1.30 | Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. ( Hehlmann, R; Heubner, C; Holm, E; König, I; König, SA; Schenk, M; Sick, C; Weiss, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Hynynen, J | 1 |
| Komulainen, T | 1 |
| Tukiainen, E | 1 |
| Nordin, A | 1 |
| Arola, J | 1 |
| Kälviäinen, R | 1 |
| Jutila, L | 1 |
| Röyttä, M | 1 |
| Hinttala, R | 1 |
| Majamaa, K | 1 |
| Mäkisalo, H | 1 |
| Uusimaa, J | 1 |
| McKiernan, P | 1 |
| Schmid, MM | 1 |
| Connemann, BJ | 1 |
| Wolf, RC | 1 |
| Flechtenmacher, C | 1 |
| Eisenbach, C | 1 |
| Schönfeldt-Lecuona, C | 1 |
| Mindikoglu, AL | 1 |
| King, D | 1 |
| Magder, LS | 1 |
| Ozolek, JA | 1 |
| Mazariegos, GV | 1 |
| Shneider, BL | 1 |
| van Zoelen, MA | 1 |
| de Graaf, M | 1 |
| van Dijk, MR | 1 |
| Bogte, A | 1 |
| van Erpecum, KJ | 1 |
| Rockmann, H | 1 |
| Maarschalk-Ellerbroek, LJ | 1 |
| Bauer, MS | 1 |
| Gordon, N | 1 |
| Kakinuma, H | 1 |
| Fujiki, T | 1 |
| Nakamura, T | 1 |
| Takahashi, H | 1 |
| Hadzić, N | 1 |
| Vara, R | 1 |
| Raiman, J | 1 |
| Mieli-Vergani, G | 1 |
| Iniesta, I | 1 |
| McFarland, R | 1 |
| Hudson, G | 1 |
| Taylor, RW | 1 |
| Green, SH | 1 |
| Hodges, S | 1 |
| McKiernan, PJ | 1 |
| Chinnery, PF | 1 |
| Ramesh, V | 1 |
| Shawcross, D | 1 |
| Auzinger, G | 1 |
| Antoniuk, SA | 1 |
| Bruck, I | 1 |
| Hönnicke, LR | 1 |
| Martins, LT | 1 |
| Carreiro, JE | 1 |
| Cat, R | 1 |
| Schwabe, MJ | 1 |
| Dobyns, WB | 1 |
| Burke, B | 1 |
| Armstrong, DL | 1 |
| König, SA | 1 |
| Schenk, M | 1 |
| Sick, C | 1 |
| Holm, E | 1 |
| Heubner, C | 1 |
| Weiss, A | 1 |
| König, I | 1 |
| Hehlmann, R | 1 |
| Delarue, A | 1 |
| Paut, O | 1 |
| Guys, JM | 1 |
| Montfort, MF | 1 |
| Lethel, V | 1 |
| Roquelaure, B | 1 |
| Pellissier, JF | 1 |
| Sarles, J | 1 |
| Camboulives, J | 1 |
| Kelly, DA | 1 |
| Kayihan, N | 1 |
| Nennesmo, I | 1 |
| Ericzon, BG | 1 |
| Németh, A | 1 |
2 reviews available for valproic acid and Liver Failure, Acute
| Article | Year |
|---|---|
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Alpers syndrome: progressive neuronal degeneration of children with liver disease.
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Humans; Liver Fai | 2006 |
17 other studies available for valproic acid and Liver Failure, Acute
| Article | Year |
|---|---|
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation.
Topics: Adolescent; Adult; Anticonvulsants; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochon | 2014 |
Acute liver failure after valproate exposure: Liver transplantation may be indicated beyond childhood.
Topics: Anticonvulsants; DNA-Directed DNA Polymerase; Female; Humans; Liver Failure, Acute; Liver Transplant | 2014 |
Can we prevent fatal liver failure under valproate?
Topics: Anticonvulsants; Bipolar Disorder; Fatal Outcome; Female; Humans; Liver; Liver Failure, Acute; Liver | 2010 |
Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; I | 2011 |
Valproic acid-induced DRESS syndrome with acute liver failure.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia; | 2012 |
Fatal hepatic failure and valproate.
Topics: Anticonvulsants; Depressive Disorder; Fatal Outcome; Humans; Liver Failure, Acute; Male; Middle Aged | 2005 |
Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy due to neonatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Child, Preschool; Echovirus Infections; Enceph | 2006 |
Old versus new antiepileptic drugs: the SANAD study.
Topics: Adolescent; Anticonvulsants; Diagnostic Errors; Female; Humans; Kearns-Sayre Syndrome; Liver Failure | 2007 |
Lamotrigine and the risk of fulminant hepatic failure.
Topics: Anticonvulsants; Cytomegalovirus Infections; Female; Humans; Lamotrigine; Liver Failure, Acute; Risk | 2007 |
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
Topics: Anticonvulsants; Child, Preschool; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochond | 2008 |
Lamotrigine and the risk of fulminant hepatic failure.
Topics: Anticonvulsants; Cytomegalovirus Infections; Female; Humans; Lamotrigine; Liver Failure, Acute; Risk | 2008 |
[Acute hepatic failure associated with valproic acid in children. Report of 3 cases].
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Liver Failure, Acute; Male; Risk Factor | 1996 |
Valproate-induced liver failure in one of two siblings with Alpers disease.
Topics: Anticonvulsants; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; Fatal Outcome; Female; Hu | 1997 |
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Comorbidity; Epilepsy; Fatal Outcome; Fem | 1999 |
Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure.
Topics: Anticonvulsants; Brain; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Diffuse Cerebr | 2000 |
Liver transplantation: to do or not to do?
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female; | 2000 |
Fatal deterioration of neurological disease after orthotopic liver transplantation for valproic acid-induced liver damage.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Electroencephalography; Epileps | 2000 |