valproic acid has been researched along with Liver Cirrhosis in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis." | 3.67 | [Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985) |
| "Valproic acid is a first-line anti-epileptic drug and a proven HDAC inhibitor." | 2.53 | Anti-fibrotic effects of valproic acid: role of HDAC inhibition and associated mechanisms. ( Ahirwar, K; Jena, G; Khan, S, 2016) |
| "mansoni)-induced liver fibrosis in mice." | 1.43 | Sodium valproate, a histone deacetylase inhibitor, with praziquantel ameliorates Schistosoma mansoni-induced liver fibrosis in mice. ( Eissa, MM; Elatrebi, SF; Elsakkar, MG; Hewedy, WA; Nassra, RM, 2016) |
| "Valproic acid (VPA) has been reported as inhibitor of histone deacetylases (HDACs)." | 1.42 | Valproate ameliorates thioacetamide-induced fibrosis by hepatic stellate cell inactivation. ( Aher, JS; Jain, S; Jena, G; Khan, S; Tikoo, K, 2015) |
| "We describe arginase deficiency in a 20-year-old woman with spastic paraplegia, progressive dystonia, dementia, peripheral neuropathy, epilepsy, liver cirrhosis, and non-B/non-C hepatocellular carcinoma." | 1.38 | Arginase deficiency with new phenotype and a novel mutation: contemporary summary. ( Ching, CK; Fung, CW; Lam, CW; Luk, HM; Mak, CM; Poon, WL; Siu, TS; Tam, S; Tsang, JP; Wong, VC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, XQ | 1 |
| Ren, ZX | 1 |
| Li, K | 1 |
| Huang, JJ | 1 |
| Huang, ZT | 1 |
| Zhou, TR | 1 |
| Cao, HY | 1 |
| Zhang, FX | 1 |
| Tan, B | 1 |
| Westra, IM | 1 |
| Oosterhuis, D | 1 |
| Groothuis, GM | 1 |
| Olinga, P | 1 |
| Aher, JS | 1 |
| Khan, S | 2 |
| Jain, S | 1 |
| Tikoo, K | 1 |
| Jena, G | 2 |
| Vinken, M | 1 |
| Aebischer, B | 1 |
| Elsig, S | 1 |
| Taeymans, J | 1 |
| Pomp, S | 1 |
| Kuhness, D | 1 |
| Barcaro, G | 1 |
| Sementa, L | 1 |
| Mankad, V | 1 |
| Fortunelli, A | 1 |
| Sterrer, M | 1 |
| Netzer, FP | 1 |
| Surnev, S | 1 |
| Schmieder, AH | 1 |
| Caruthers, SD | 1 |
| Keupp, J | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Lowe, J | 1 |
| Wodarcyk, AJ | 1 |
| Floyd, KT | 1 |
| Rastogi, N | 1 |
| Schultz, EJ | 1 |
| Swager, SA | 1 |
| Chadwick, JA | 1 |
| Tran, T | 1 |
| Raman, SV | 1 |
| Janssen, PM | 1 |
| Rafael-Fortney, JA | 1 |
| Alcalay, RN | 1 |
| Levy, OA | 1 |
| Wolf, P | 1 |
| Oliva, P | 1 |
| Zhang, XK | 1 |
| Waters, CH | 1 |
| Fahn, S | 1 |
| Kang, U | 1 |
| Liong, C | 1 |
| Ford, B | 1 |
| Mazzoni, P | 1 |
| Kuo, S | 1 |
| Johnson, A | 1 |
| Xiong, L | 1 |
| Rouleau, GA | 1 |
| Chung, W | 1 |
| Marder, KS | 1 |
| Gan-Or, Z | 1 |
| Kamei, K | 1 |
| Terao, T | 1 |
| Katayama, Y | 1 |
| Hatano, K | 1 |
| Kodama, K | 1 |
| Shirahama, M | 1 |
| Sakai, A | 1 |
| Hirakawa, H | 1 |
| Mizokami, Y | 1 |
| Shiotsuki, I | 1 |
| Ishii, N | 1 |
| Inoue, Y | 1 |
| Akboga, MK | 1 |
| Yayla, C | 1 |
| Balci, KG | 1 |
| Ozeke, O | 1 |
| Maden, O | 1 |
| Kisacik, H | 1 |
| Temizhan, A | 1 |
| Aydogdu, S | 1 |
| Zhu, J | 2 |
| Ying, SH | 1 |
| Feng, MG | 1 |
| Zhang, XG | 1 |
| Li, H | 1 |
| Wang, L | 1 |
| Hao, YY | 1 |
| Liang, GD | 1 |
| Ma, YH | 1 |
| Yang, GS | 1 |
| Hu, JH | 1 |
| Pfeifer, L | 1 |
| Goertz, RS | 1 |
| Neurath, MF | 1 |
| Strobel, D | 1 |
| Wildner, D | 1 |
| Lin, JT | 1 |
| Yang, XN | 1 |
| Zhong, WZ | 1 |
| Liao, RQ | 1 |
| Dong, S | 1 |
| Nie, Q | 1 |
| Weng, SX | 1 |
| Fang, XJ | 1 |
| Zheng, JY | 1 |
| Wu, YL | 1 |
| Řezanka, T | 1 |
| Kaineder, K | 1 |
| Mezricky, D | 1 |
| Řezanka, M | 1 |
| Bišová, K | 1 |
| Zachleder, V | 1 |
| Vítová, M | 1 |
| Rinker, JA | 1 |
| Marshall, SA | 1 |
| Mazzone, CM | 1 |
| Lowery-Gionta, EG | 1 |
| Gulati, V | 1 |
| Pleil, KE | 1 |
| Kash, TL | 1 |
| Navarro, M | 1 |
| Thiele, TE | 1 |
| Zhang, Y | 1 |
| Huang, Y | 1 |
| Jin, Z | 1 |
| Li, X | 1 |
| Li, B | 1 |
| Xu, P | 1 |
| Huang, P | 1 |
| Liu, C | 1 |
| Fokdal, L | 1 |
| Sturdza, A | 1 |
| Mazeron, R | 1 |
| Haie-Meder, C | 1 |
| Tan, LT | 1 |
| Gillham, C | 1 |
| Šegedin, B | 1 |
| Jürgenliemk-Schultz, I | 1 |
| Kirisits, C | 1 |
| Hoskin, P | 1 |
| Pötter, R | 1 |
| Lindegaard, JC | 1 |
| Tanderup, K | 1 |
| Levin, DE | 1 |
| Schmitz, AJ | 1 |
| Hines, SM | 1 |
| Hines, KJ | 1 |
| Tucker, MJ | 1 |
| Brewer, SH | 1 |
| Fenlon, EE | 1 |
| Álvarez-Pérez, S | 1 |
| Blanco, JL | 1 |
| Peláez, T | 1 |
| Martínez-Nevado, E | 1 |
| García, ME | 1 |
| Puckerin, AA | 1 |
| Chang, DD | 1 |
| Subramanyam, P | 1 |
| Colecraft, HM | 1 |
| Dogan, H | 1 |
| Coteli, E | 1 |
| Karatas, F | 1 |
| Ceylan, O | 1 |
| Sahin, MD | 1 |
| Akdamar, G | 1 |
| Kryczyk, A | 1 |
| Żmudzki, P | 1 |
| Hubicka, U | 1 |
| Giovannelli, D | 1 |
| Chung, M | 1 |
| Staley, J | 1 |
| Starovoytov, V | 1 |
| Le Bris, N | 1 |
| Vetriani, C | 1 |
| Chen, W | 1 |
| Wu, L | 1 |
| Liu, X | 1 |
| Shen, Y | 1 |
| Liang, Y | 1 |
| Tan, H | 1 |
| Yang, Y | 1 |
| Liu, Q | 1 |
| Wang, M | 1 |
| Liu, L | 1 |
| Wang, X | 1 |
| Liu, B | 1 |
| Liu, GH | 1 |
| Zhu, YJ | 1 |
| Wang, JP | 1 |
| Che, JM | 1 |
| Chen, QQ | 1 |
| Chen, Z | 1 |
| Maucksch, U | 1 |
| Runge, R | 1 |
| Wunderlich, G | 1 |
| Freudenberg, R | 1 |
| Naumann, A | 1 |
| Kotzerke, J | 1 |
| Ahirwar, K | 1 |
| Elsakkar, MG | 1 |
| Eissa, MM | 1 |
| Hewedy, WA | 1 |
| Nassra, RM | 1 |
| Elatrebi, SF | 1 |
| Ikura, Y | 1 |
| Iwasa, Y | 1 |
| Ueda, M | 1 |
| Spriet, I | 1 |
| Willems, L | 1 |
| Watanabe, T | 1 |
| Tajima, H | 1 |
| Hironori, H | 1 |
| Nakagawara, H | 1 |
| Ohnishi, I | 1 |
| Takamura, H | 1 |
| Ninomiya, I | 1 |
| Kitagawa, H | 1 |
| Fushida, S | 1 |
| Tani, T | 1 |
| Fujimura, T | 1 |
| Ota, T | 1 |
| Wakayama, T | 1 |
| Iseki, S | 1 |
| Harada, S | 1 |
| Tsang, JP | 1 |
| Poon, WL | 1 |
| Luk, HM | 1 |
| Fung, CW | 1 |
| Ching, CK | 1 |
| Mak, CM | 1 |
| Lam, CW | 1 |
| Siu, TS | 1 |
| Tam, S | 1 |
| Wong, VC | 1 |
| Nevoral, J | 1 |
| Janda, J | 1 |
| Hanika, J | 1 |
| Svec, M | 1 |
| Honzová, S | 1 |
| Bach, N | 1 |
| Thung, SN | 1 |
| Schaffner, F | 1 |
| Tobias, H | 1 |
| Böhles, H | 1 |
| Zäh, W | 1 |
| Rengeling, M | 1 |
| Rühl, G | 1 |
| Hackenberg, K | 1 |
3 reviews available for valproic acid and Liver Cirrhosis
| Article | Year |
|---|---|
Adverse Outcome Pathways and Drug-Induced Liver Injury Testing.
Topics: Bosentan; Chemical and Drug Induced Liver Injury; Cholestasis; Fatty Liver; Humans; Liver Cirrhosis; | 2015 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Anti-fibrotic effects of valproic acid: role of HDAC inhibition and associated mechanisms.
Topics: Animals; Cystic Fibrosis; Epigenesis, Genetic; Fibrosis; Histone Deacetylase Inhibitors; Humans; Kid | 2016 |
12 other studies available for valproic acid and Liver Cirrhosis
| Article | Year |
|---|---|
Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis.
Topics: Biomarkers; Computational Biology; Gene Expression Profiling; Gene Expression Regulation; Gene Ontol | 2018 |
Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Topics: Animals; Becaplermin; Benzamides; Benzylisoquinolines; Cinnamates; Collagen Type I; Connective Tissu | 2014 |
Valproate ameliorates thioacetamide-induced fibrosis by hepatic stellate cell inactivation.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Body Weight; Comet Assay; DNA | 2015 |
Sodium valproate, a histone deacetylase inhibitor, with praziquantel ameliorates Schistosoma mansoni-induced liver fibrosis in mice.
Topics: Animals; Anthelmintics; Histone Deacetylase Inhibitors; Liver Cirrhosis; Male; Mice; Praziquantel; S | 2016 |
Valproic acid administration for hepatic fibrosis: a balance between antifibrotic efficacy and hepatotoxicity.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Hepatic Stellate Cells; Humans; Li | 2010 |
No interaction between valproate and meropenem in a cirrhotic patient.
Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Enterobacteriaceae Infections; Epilepsy, | 2011 |
Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line.
Topics: Autocrine Communication; Cell Line; Cell Proliferation; Collagen Type I; Hepatic Stellate Cells; His | 2011 |
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Topics: Anticonvulsants; Arginase; Base Sequence; Carcinoma, Hepatocellular; Cerebral Palsy; Codon, Nonsense | 2012 |
[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
Topics: Child; Drug Hypersensitivity; Epilepsy; Humans; Liver; Liver Cirrhosis; Male; Necrosis; Transaminase | 1993 |
Exaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproate.
Topics: Chlorpromazine; Cholestasis; Drug Interactions; Hiccup; Humans; Liver Cirrhosis; Male; Middle Aged; | 1989 |
[When is parenteral carnitine administration indicated?].
Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Pr | 1986 |
[Acute liver necrosis caused by valproate].
Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi | 1985 |