valproic acid has been researched along with Leukopenia in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The charts of 55 patients receiving clozapine and valproate concurrently between May 8, 1989, and May 8, 1992, were reviewed to determine the indication for and length of time on each medication, abnormalities in liver function test results, blood cell dyscrasias, seizures, nausea, vomiting, sedation, sialorrhea, and enuresis." | 7.69 | Concurrent use of clozapine and valproate in affective and psychotic disorders. ( Castillo, J; Centorrino, F; Kando, JC; Tohen, M, 1994) |
| "The purpose of this study was to determine the occurrence of leukopenia and other blood dyscrasias associated with psychiatric use of carbamazepine and valproate." | 3.69 | Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk. ( Baldessarini, RJ; Castillo, J; Kando, JC; Tohen, M; Zarate, C, 1995) |
| "The charts of 55 patients receiving clozapine and valproate concurrently between May 8, 1989, and May 8, 1992, were reviewed to determine the indication for and length of time on each medication, abnormalities in liver function test results, blood cell dyscrasias, seizures, nausea, vomiting, sedation, sialorrhea, and enuresis." | 3.69 | Concurrent use of clozapine and valproate in affective and psychotic disorders. ( Castillo, J; Centorrino, F; Kando, JC; Tohen, M, 1994) |
| "The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year." | 3.66 | [Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| "Leukopenia and neutropenia are recognised as side effects of antipsychotic medication, notably clozapine." | 1.34 | Leukopenia and neutropenia induced by quetiapine. ( Cowan, C; Oakley, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, SW | 1 |
| Chang, HR | 1 |
| Lai, YR | 1 |
| Lian, JD | 1 |
| Rahman, A | 1 |
| Mican, LM | 1 |
| Fischer, C | 1 |
| Campbell, AH | 1 |
| Imbarlina, MJ | 1 |
| Sarkar, S | 1 |
| Marwah, S | 1 |
| Parepally, H | 1 |
| Johnston, PR | 1 |
| Brar, JS | 1 |
| Chengappa, KN | 1 |
| Cowan, C | 1 |
| Oakley, C | 1 |
| Tohen, M | 3 |
| Castillo, J | 3 |
| Baldessarini, RJ | 1 |
| Zarate, C | 1 |
| Kando, JC | 3 |
| Centorrino, F | 1 |
| Zarate, CA | 1 |
| Dose, M | 1 |
| Hellweg, R | 1 |
| Yassouridis, A | 1 |
| Theison, M | 1 |
| Emrich, HM | 1 |
| Storch, DD | 1 |
| Miller, PR | 1 |
| Fröscher, W | 1 |
| Schulz, HU | 1 |
| Gugler, R | 1 |
| Mori, H | 1 |
| Nagai, H | 1 |
| Koda, A | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Bauer, J | 1 |
| Penin, H | 1 |
| Burr, W | 1 |
1 review available for valproic acid and Leukopenia
| Article | Year |
|---|---|
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
1 trial available for valproic acid and Leukopenia
| Article | Year |
|---|---|
Combined treatment of schizophrenic psychoses with haloperidol and valproate.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Biperiden; Brief Psychiatric Rating Scale; Chlo | 1998 |
12 other studies available for valproic acid and Leukopenia
| Article | Year |
|---|---|
Non-life-threatening leukopenia in a renal transplant recipient with acute overdose of mycophenolate mofetil.
Topics: Adult; Antidepressive Agents; Benzodiazepines; Charcoal; Cholestyramine Resin; Depressive Disorder; | 2008 |
Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents.
Topics: Adolescent; Anticonvulsants; Child; Dibenzothiazepines; Drug Therapy, Combination; Female; Hospitali | 2009 |
Leukopenia in clozapine treated patients may be induced by other drugs: a case series.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Clozapine; Drug Resistance; Female; Humans; Leukocyte | 2004 |
Leukopenia and neutropenia induced by quetiapine.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Dibenzothiazepines; Drug Resistance; Female; Humans; | 2007 |
Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk.
Topics: Adolescent; Adult; Anemia; Carbamazepine; Depressive Disorder; Desipramine; Drug Therapy, Combinatio | 1995 |
Concurrent use of clozapine and valproate in affective and psychotic disorders.
Topics: Adult; Clozapine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Incidence | 1994 |
The use of valproate in an elderly population with affective symptoms.
Topics: Affective Disorders, Psychotic; Age Factors; Aged; Antimanic Agents; Comorbidity; Depressive Disorde | 1996 |
Severe leukopenia with valproate.
Topics: Adult; Antimanic Agents; Child; Humans; Leukocyte Count; Leukopenia; Male; Neutrophils; Valproic Aci | 2000 |
Clozapine therapy for a patient with a history of Hodgkin's disease.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clozapine; Drug Therapy, Combination; Female; Hodgkin | 2001 |
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T | 1979 |
[Effect of alpha-mercaptopropionylglycine (alpha-MPG) and sodium dipropylacetate (DPA) on antibody formation (II). Immunosuppression induced by carcinostatic agents and glucocorticoid (author's transl)].
Topics: Amino Acids, Sulfur; Animals; Antibody Formation; Antineoplastic Agents; Hemolytic Plaque Technique; | 1978 |
[Side effects of valproic acid therapy in adulthood].
Topics: alpha-Amylases; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukopenia; Liver Function Test | 1988 |