valproic acid has been researched along with Landau-Kleffner Syndrome in 16 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Landau-Kleffner Syndrome: A syndrome characterized by the onset of isolated language dysfunction in otherwise normal children (age of onset 4-7 years) and epileptiform discharges on ELECTROENCEPHALOGRAPHY. Seizures, including atypical absence (EPILEPSY, ABSENCE), complex partial (EPILEPSY, COMPLEX PARTIAL), and other types may occur. The electroencephalographic abnormalities and seizures tend to resolve by puberty. The language disorder may also resolve although some individuals are left with severe language dysfunction, including APHASIA and auditory AGNOSIA. (From Menkes, Textbook of Child Neurology, 5th ed, pp749-50; J Child Neurol 1997 Nov;12(8):489-495).
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, EEG was abnormal and the boy was diagnosed as a case of Landau-Kleffner syndrome (LKS) and treated with sodium valproate, levetiracetam and steroids." | 3.81 | Landau-Kleffner syndrome: an uncommon dealt with case in Southeast Asia. ( Afsar, S; Dixit, NS; Motwani, N; Sharma, N, 2015) |
| "Oral treatment of carbamazepine was started but her seizures were not controlled." | 1.40 | Serial EEG study in a girl with Landau-Kleffner syndrome associated with continuous spikes and waves during slow sleep. ( Arisaka, O; Imataka, G, 2014) |
| " Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased." | 1.32 | Visual hallucinations associated with zonisamide. ( Akman, CI; Goodkin, HP; Riviello, JJ; Rogers, DP, 2003) |
| " Valproates in dosage 30-60 mg/kg daily were highly effective for stopping epileptic seizures." | 1.32 | [Electroclinical characteristics of Landau-Kleffner syndrome]. ( Glukhova, LIu; Kholin, AA; Mukhin, KIu; Petrukhin, AS; Zaĭtseva, MN, 2003) |
| "Landau-Kleffner syndrome is marked by an acquired aphasia in children who have had normal language and motor development." | 1.31 | Landau-Kleffner syndrome beginning with stuttering: case report. ( Kadioğlu, B; Serdaroğlu, G; Tütüncüoğlu, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imataka, G | 1 |
| Arisaka, O | 1 |
| Uğur, C | 1 |
| Saday Duman, N | 1 |
| Bektaş, O | 1 |
| Kağan Gürkan, C | 1 |
| Motwani, N | 1 |
| Afsar, S | 1 |
| Dixit, NS | 1 |
| Sharma, N | 1 |
| Lagae, L | 1 |
| Liukkonen, E | 1 |
| Kantola-Sorsa, E | 1 |
| Paetau, R | 1 |
| Gaily, E | 1 |
| Peltola, M | 1 |
| Granström, ML | 1 |
| Ribeiro, KM | 1 |
| Assumpção, FB | 1 |
| Valente, KD | 1 |
| Akman, CI | 1 |
| Goodkin, HP | 1 |
| Rogers, DP | 1 |
| Riviello, JJ | 1 |
| Tütüncüoğlu, S | 1 |
| Serdaroğlu, G | 1 |
| Kadioğlu, B | 1 |
| Kossoff, EH | 1 |
| Boatman, D | 1 |
| Freeman, JM | 1 |
| Mukhin, KIu | 1 |
| Kholin, AA | 1 |
| Petrukhin, AS | 1 |
| Glukhova, LIu | 1 |
| Zaĭtseva, MN | 1 |
| Kamimura, T | 1 |
| Kanazawa, O | 1 |
| Tohyama, J | 1 |
| Akasaka, N | 1 |
| Uchiyama, M | 1 |
| Karlov, VA | 1 |
| Gnezditskiĭ, VV | 1 |
| Pedro, VM | 1 |
| Leisman, G | 1 |
| Nieto Barrera, M | 1 |
| López Alcaide, MI | 1 |
| Candau Fernández-Mensaque, R | 1 |
| Ruiz del Portal Bermudo, L | 1 |
| Rufo Campos, M | 1 |
| Correa Charro, A | 1 |
| Sayit, E | 1 |
| Dirik, E | 1 |
| Durak, H | 1 |
| Uzuner, N | 1 |
| Anal, O | 1 |
| Cevik, NT | 1 |
| Bharani, S | 1 |
| Trivedi, C | 1 |
| Shendurnikar, N | 1 |
| Gandhi, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Levetiracetam for Language Dysfunction Associated With Benign Epilepsy With Centrotemporal Spikes[NCT00181116] | Phase 4 | 6 participants | Interventional | 2005-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for valproic acid and Landau-Kleffner Syndrome
| Article | Year |
|---|---|
Serial EEG study in a girl with Landau-Kleffner syndrome associated with continuous spikes and waves during slow sleep.
Topics: Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Female; Humans; Infant; Landau-Kleffn | 2014 |
Antiepileptic treatment in a child with Landau Kleffner syndrome: a case report.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Landau-Kleffner Syndro | 2014 |
Landau-Kleffner syndrome: an uncommon dealt with case in Southeast Asia.
Topics: Anticonvulsants; Aphasia; Asia, Southeastern; Child; Electroencephalography; Humans; Landau-Kleffner | 2015 |
Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years.
Topics: Anticonvulsants; Behavior Therapy; Benzodiazepines; Child; Combined Modality Therapy; Diet, Ketogeni | 2009 |
Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome.
Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Drug Therapy, Combination; Electroencephalo | 2010 |
[Landau-Kleffner and autistic regression: the importance of differential diagnosis].
Topics: Anticonvulsants; Autistic Disorder; Child, Preschool; Diagnosis, Differential; Electroencephalograph | 2002 |
Visual hallucinations associated with zonisamide.
Topics: Adolescent; Adult; Anticonvulsants; Child; Female; Hallucinations; Humans; Landau-Kleffner Syndrome; | 2003 |
Landau-Kleffner syndrome beginning with stuttering: case report.
Topics: Adrenocorticotropic Hormone; Aphasia; Child, Preschool; Diagnosis, Differential; Electroencephalogra | 2002 |
Landau-Kleffner syndrome responsive to levetiracetam.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Female; Humans; Landau-Kleffner Syndrome; | 2003 |
[Electroclinical characteristics of Landau-Kleffner syndrome].
Topics: Anticonvulsants; Brain; Child; Diagnosis, Differential; Electroencephalography; Female; Humans; Land | 2003 |
[Serial MEG change in a boy with Landau-Kleffner syndrome].
Topics: Anticonvulsants; Child; Clonazepam; Drug Therapy, Combination; Evoked Potentials, Auditory; Humans; | 2004 |
[Bifocal atypical rolandic epilepsy with speech dyspraxia].
Topics: Anti-Inflammatory Agents; Anticonvulsants; Apraxias; Child; Diagnosis, Differential; Electroencephal | 2004 |
Hemispheric integrative therapy in Landau-Kleffner syndrome: applications for rehabilitation sciences.
Topics: Adolescent; Anticonvulsants; Brain; Central Nervous System Stimulants; Electroencephalography; Femal | 2005 |
[Acquired aphasic epilepsy (Landau-Kleffner syndrome). Report of 10 cases].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Aphasia; Brain; Carbamazepine; Child; Child, Preschool | 1997 |
Landau-Kleffner syndrome: relation of clinical, EEG and Tc-99m-HMPAO brain SPECT findings and improvement in EEG after treatment.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebrovascular Circulation; Child, Preschool; Clonazepam; De | 1999 |
Landau Kleffner syndrome.
Topics: Child; Diagnosis, Differential; Electroencephalography; Humans; Landau-Kleffner Syndrome; Male; Valp | 2001 |