valproic acid has been researched along with Koch's Disease in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " tuberculosis H37Rv cultures were exposed to VPA or SAHA over 6 days, in the presence or absence of isoniazid (INH) and rifampicin (RIF)." | 7.88 | Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis. ( Maeurer, M; Rao, M; Valentini, D; Zumla, A, 2018) |
| " tuberculosis H37Rv cultures were exposed to VPA or SAHA over 6 days, in the presence or absence of isoniazid (INH) and rifampicin (RIF)." | 3.88 | Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis. ( Maeurer, M; Rao, M; Valentini, D; Zumla, A, 2018) |
| "Neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (PFC) and cerebellum (CER) of pups." | 1.62 | Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. ( Manjeese, W; Mpofana, T; Mvubu, NE; Steyn, AJC, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Manjeese, W | 1 |
| Mvubu, NE | 1 |
| Steyn, AJC | 1 |
| Mpofana, T | 1 |
| Rao, M | 1 |
| Valentini, D | 1 |
| Zumla, A | 1 |
| Maeurer, M | 1 |
| Dockweiler, U | 1 |
3 other studies available for valproic acid and Koch's Disease
| Article | Year |
|---|---|
Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring.
Topics: Adult; Animals; Astrocytes; Autism Spectrum Disorder; Blood-Brain Barrier; Cell Count; Cerebellum; F | 2021 |
Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoniazid; Macropha | 2018 |
Isoniazid-induced valproic-acid toxicity, or vice versa.
Topics: Adolescent; Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Tuberculosis; Valproic Acid | 1987 |