valproic acid has been researched along with Kidney Failure, Chronic in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders." | 7.68 | Pancreatitis in children on chronic dialysis treated with valproic acid. ( Ford, DM; Lum, GM; Portman, RJ, 1990) |
| "Pancreatitis is a serious adverse effect of valproic acid (VPA)." | 3.70 | On the toxicity of valproic-acid. ( Alonso, R; Cuiña, L; Moreiras Plaza, M; Rodríguez Goyanes, G, 1999) |
| "Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders." | 3.68 | Pancreatitis in children on chronic dialysis treated with valproic acid. ( Ford, DM; Lum, GM; Portman, RJ, 1990) |
| "Cases of acute pancreatitis caused by sodium valproate (VPA) have been reported by many authors thus far." | 1.40 | Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report. ( Okayasu, H; Osone, A; Ozeki, Y; Shimoda, K; Shinozaki, T, 2014) |
| "We treated a 31-year-old woman with systemic lupus erythematosus, renal failure with nephrotic syndrome, and a long-standing seizure disorder, who developed severe hyperammonemia with a fatal outcome." | 1.30 | Fatal hyperammonemia in a patient with systemic lupus erythematosus. ( Amano, T; Ichikawa, H; Kawabata, K; Kushiro, M; Makino, H; Nagake, Y; Wada, J, 1998) |
| "Valproic acid was proved to be effective in reducing the number of attacks over 4 months." | 1.30 | Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. ( Fujieda, M; Kurashige, T; Machida, Y; Maeda, A; Maeda, H; Naruse, K; Okada, T; Ushida, M; Wakiguchi, H; Yokoyama, W, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okayasu, H | 1 |
| Shinozaki, T | 1 |
| Osone, A | 1 |
| Ozeki, Y | 1 |
| Shimoda, K | 1 |
| Rosenberg, SL | 1 |
| Chen, S | 1 |
| McLaughlin, N | 1 |
| El-Dahr, SS | 1 |
| Burtey, S | 1 |
| Dai, XY | 1 |
| Zhao, MM | 1 |
| Cai, Y | 1 |
| Guan, QC | 1 |
| Zhao, Y | 1 |
| Guan, Y | 1 |
| Kong, W | 1 |
| Zhu, WG | 1 |
| Xu, MJ | 1 |
| Wang, X | 1 |
| Ferrari, R | 1 |
| Merli, E | 1 |
| Cicchitelli, G | 1 |
| Mele, D | 1 |
| Fucili, A | 1 |
| Ceconi, C | 1 |
| Schneider, AL | 1 |
| Wacarda, L | 1 |
| von Klitzing, E | 1 |
| Kochen, W | 1 |
| Hellenbrecht, D | 1 |
| Bruni, J | 1 |
| Wang, LH | 1 |
| Marbury, TC | 1 |
| Lee, CS | 1 |
| Wilder, BJ | 1 |
| Elias, AN | 1 |
| Pahl, M | 1 |
| Stone, S | 1 |
| Vaziri, ND | 1 |
| Valenta, LJ | 1 |
| Jefferson, JW | 1 |
| Sen, D | 1 |
| Levin, TL | 1 |
| Berdon, WE | 1 |
| Seigle, RR | 1 |
| Nash, MA | 1 |
| Driessen, JJ | 1 |
| Robertson, EN | 1 |
| Booij, LH | 1 |
| Vree, TB | 1 |
| Ichikawa, H | 1 |
| Amano, T | 1 |
| Kawabata, K | 1 |
| Kushiro, M | 1 |
| Wada, J | 1 |
| Nagake, Y | 1 |
| Makino, H | 1 |
| Yokoyama, W | 1 |
| Fujieda, M | 1 |
| Okada, T | 1 |
| Maeda, H | 1 |
| Ushida, M | 1 |
| Machida, Y | 1 |
| Naruse, K | 1 |
| Maeda, A | 1 |
| Wakiguchi, H | 1 |
| Kurashige, T | 1 |
| Lapierre, O | 1 |
| Dubreucq, JL | 1 |
| Beauchemin, MA | 1 |
| Vinet, B | 1 |
| Moreiras Plaza, M | 1 |
| Rodríguez Goyanes, G | 1 |
| Cuiña, L | 1 |
| Alonso, R | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Ritter, G | 1 |
| Sungur, C | 1 |
| Sungur, A | 1 |
| Akpolat, T | 1 |
| Yasavul, U | 1 |
| Turgan, C | 1 |
| Caglar, S | 1 |
| Ford, DM | 1 |
| Portman, RJ | 1 |
| Lum, GM | 1 |
| Sedman, AJ | 1 |
| Molitoris, BA | 1 |
| Nakata, LM | 1 |
| Gal, J | 1 |
| Böhles, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for valproic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Regulation of kidney development by histone deacetylases.
Topics: Animals; Child; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, | 2011 |
[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Chromosomes, Human, Pair 16; Clini | 2011 |
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.
Topics: Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Humans; Kidney Failure, Chronic; Liver; Myoc | 2004 |
17 other studies available for valproic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report.
Topics: Abdominal Pain; Acute Disease; Anticonvulsants; Bipolar Disorder; Humans; Japan; Kidney Failure, Chr | 2014 |
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Topics: Adenine; Alkaline Phosphatase; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Autophagy; Au | 2013 |
Experimental observations on peritoneal transport in rabbits.
Topics: Animals; Biological Transport; Creatinine; Disease Models, Animal; Dopamine; Fenoterol; Inulin; Isop | 1983 |
Protein binding of valproic acid in uremic patients.
Topics: Humans; Kidney Failure, Chronic; Protein Binding; Renal Dialysis; Uremia; Valproic Acid | 1980 |
Modulatory role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin secretion in patients with chronic renal failure.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Gonadotropin-Releas | 1982 |
Manic depressive disorder and lithium over the decades: the very educational case of Mrs. L.
Topics: Aged; Aged, 80 and over; Bipolar Disorder; Drug Administration Schedule; Electroconvulsive Therapy; | 1994 |
Valproic-acid-associated pancreatitis and hepatic toxicity in children with endstage renal disease.
Topics: Adolescent; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Fatal Outcome; Fatty Liv | 1997 |
Accelerated recovery and disposition from rocuronium in an end-stage renal failure patient on chronic anticonvulsant therapy with sodium valproate and primidone.
Topics: Adult; Androstanols; Anticonvulsants; Drug Interactions; Humans; Kidney Failure, Chronic; Male; Neur | 1998 |
Fatal hyperammonemia in a patient with systemic lupus erythematosus.
Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Fatal Outcome; Female; Humans; Kidney Failure, Chro | 1998 |
Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis.
Topics: Adrenocorticotropic Hormone; Child; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chr | 1998 |
Valproic acid intoxication in a patient with bipolar disorder and chronic uremia.
Topics: Antimanic Agents; Bipolar Disorder; Depression; Female; Humans; Hypokinesia; Kidney Failure, Chronic | 1999 |
On the toxicity of valproic-acid.
Topics: Acute Disease; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Humans; Kidney Failure, Chronic; Male | 1999 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Unresponsiveness to human recombinant erythropoietin in an epileptic dialysis patient secondary to valproic acid toxicity.
Topics: Adult; Electrocardiography; Epilepsy, Tonic-Clonic; Erythropoietin; Female; Humans; Kidney Failure, | 1992 |
Pancreatitis in children on chronic dialysis treated with valproic acid.
Topics: Child; Child, Preschool; Female; Humans; Infant; Kidney Failure, Chronic; Male; Pancreatitis; Renal | 1990 |
Therapeutic drug monitoring in patients with chronic renal failure: evaluation of the Abbott TDx drug assay system.
Topics: Carbamazepine; Cross Reactions; Digoxin; Gentamicins; Humans; Immunoassay; Kidney Failure, Chronic; | 1986 |
[When is parenteral carnitine administration indicated?].
Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Pr | 1986 |