valproic acid has been researched along with Injury, Ischemia-Reperfusion in 18 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The antiepileptic drug valproic acid (VPA) was reported to protect cerebral ischemia/reperfusion injury." | 7.91 | Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways. ( Cheng, YY; Guan, L; Jia, LQ; Liu, Y; Min, DY; Song, N; Wang, LJ; Yang, GL; Yang, YJ; Zhan, KX; Zhang, Z; Zhu, S, 2019) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 6.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 5.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| " The antiepileptic drug valproic acid (VPA) was reported to protect cerebral ischemia/reperfusion injury." | 3.91 | Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways. ( Cheng, YY; Guan, L; Jia, LQ; Liu, Y; Min, DY; Song, N; Wang, LJ; Yang, GL; Yang, YJ; Zhan, KX; Zhang, Z; Zhu, S, 2019) |
| " The creatinine clearance, serum urea, uric acid, lactate dehydrogenase, potassium, fractional excretion of sodium, and microproteinuria were measured to assess kidney injury." | 3.80 | Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. ( Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP, 2014) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 2.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 1.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that may decrease cellular metabolic needs following traumatic injury." | 1.39 | Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury. ( Alam, H; Causey, MW; Hempel, J; Hoffer, Z; Jin, G; Martin, M; Miller, S; Stallings, JD, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 17 (94.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amirzargar, MA | 1 |
| Yaghubi, F | 1 |
| Hosseinipanah, M | 1 |
| Jafari, M | 1 |
| Pourjafar, M | 1 |
| Rezaeepoor, M | 1 |
| Rezaei, H | 1 |
| Roshanaei, G | 1 |
| Hajilooi, M | 1 |
| Solgi, G | 1 |
| Hernández de G, MM | 1 |
| Garay F, JL | 1 |
| Loureiro, NE | 1 |
| Zhu, S | 1 |
| Zhang, Z | 4 |
| Jia, LQ | 1 |
| Zhan, KX | 1 |
| Wang, LJ | 1 |
| Song, N | 1 |
| Liu, Y | 1 |
| Cheng, YY | 1 |
| Yang, YJ | 1 |
| Guan, L | 1 |
| Min, DY | 1 |
| Yang, GL | 1 |
| Suda, S | 1 |
| Katsura, K | 1 |
| Kanamaru, T | 1 |
| Saito, M | 1 |
| Katayama, Y | 1 |
| Causey, MW | 2 |
| Miller, S | 1 |
| Hoffer, Z | 1 |
| Hempel, J | 1 |
| Stallings, JD | 3 |
| Jin, G | 2 |
| Alam, H | 1 |
| Martin, M | 2 |
| Brar, R | 1 |
| Singh, JP | 1 |
| Kaur, T | 1 |
| Arora, S | 1 |
| Singh, AP | 1 |
| Alsarraf, O | 1 |
| Fan, J | 1 |
| Dahrouj, M | 1 |
| Chou, CJ | 1 |
| Menick, DR | 1 |
| Crosson, CE | 1 |
| Wu, SY | 1 |
| Tang, SE | 1 |
| Ko, FC | 1 |
| Wu, GC | 1 |
| Huang, KL | 1 |
| Chu, SJ | 1 |
| Speir, RW | 1 |
| Andrews, JM | 1 |
| Gelnett, MS | 1 |
| Brand, TC | 1 |
| Salgar, SK | 1 |
| Costalonga, EC | 1 |
| Silva, FM | 1 |
| Noronha, IL | 1 |
| Ruess, DA | 1 |
| Probst, M | 1 |
| Marjanovic, G | 1 |
| Wittel, UA | 1 |
| Hopt, UT | 1 |
| Keck, T | 1 |
| Bausch, D | 1 |
| Kim, K | 1 |
| Li, Y | 1 |
| Chong, W | 1 |
| Liu, B | 1 |
| Lu, J | 1 |
| Lee, K | 1 |
| Demoya, M | 1 |
| Velmahos, GC | 1 |
| Alam, HB | 1 |
| Tong, N | 3 |
| Gong, Y | 3 |
| Qiu, Q | 1 |
| Yin, L | 1 |
| Lv, X | 1 |
| Wu, X | 3 |
| Salgar, S | 1 |
| Singh, N | 1 |
| Qin, X | 2 |
| Zhao, X | 2 |
| Shi, Y | 1 |
| Zhang, W | 2 |
| Zhang, ZZ | 1 |
| Wu, XW | 1 |
| Gong, YY | 1 |
| Yin, LL | 1 |
| Verrotti, A | 1 |
| Tana, M | 1 |
| Pelliccia, P | 1 |
| Chiarelli, F | 1 |
| Latini, G | 1 |
1 review available for valproic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Recent advances on neural tube defects with special reference to Valproic Acid.
Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Defici | 2006 |
17 other studies available for valproic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Anti-inflammatory Effects of Valproic Acid in a Rat Model of Renal Ischemia/Reperfusion Injury: Alteration in Cytokine Profile.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; Cytokines; Interleukin-10; Inter | 2017 |
Neuroprotective action of valproic acid accompanied of the modification on the expression of Bcl-2 and activated caspase-3 in the brain of rats submitted to ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Caspase 3; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; R | 2015 |
Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cell Survival; Cells, Cultured; Dose-Response Relationship | 2019 |
Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Brain Ischemia; Disease Models, Animal; In Situ Nic | 2013 |
Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.
Topics: Acidosis; Animals; Disease Models, Animal; Epinephrine; Hemorrhage; Histone Deacetylase Inhibitors; | 2013 |
Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Catalase; Creatinine; GABA Agents; Glutathione; Kidney; L-Lactate Dehy | 2014 |
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Topics: Acetylation; Animals; Blotting, Western; Caspase 3; Cell Survival; Electroretinography; Female; Hist | 2014 |
Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats.
Topics: Acetylation; Acute Lung Injury; Animals; Antioxidants; Body Weight; Capillary Permeability; Heme Oxy | 2015 |
Effects of valproic acid and dexamethasone administration on early bio-markers and gene expression profile in acute kidney ischemia-reperfusion injury in the rat.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Cell Adhesion Molecules; Dexamethasone; Dr | 2015 |
Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Male; Nephritis; Rats; Rats, Wistar; Reperfu | 2016 |
HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury.
Topics: Acetylation; Animals; Anticonvulsants; Histone Deacetylase Inhibitors; Liver; Male; Protective Agent | 2016 |
Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme Inhibitors; Follow-Up Studies; Intestines | 2012 |
Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Caspase 12; Cell Death; Endoplasmic Reticulu | 2011 |
Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia-reperfusion injury in a swine hemorrhagic shock model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Gene Exp | 2012 |
Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation.
Topics: Acetylation; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Axons; Caspase 3; Cytochrom | 2012 |
Valproic acid regulates antioxidant enzymes and prevents ischemia/reperfusion injury in the rat retina.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Injecti | 2012 |
[Protective effect of valproic acid on ischemia-reperfusion induced injury in retina of rat].
Topics: Animals; bcl-2-Associated X Protein; HSP70 Heat-Shock Proteins; Male; Proto-Oncogene Proteins c-bcl- | 2012 |