valproic acid has been researched along with Injuries in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare rates of self-harm, unintentional injury, and suicide in patients with bipolar disorder who were prescribed lithium, valproate sodium, olanzapine, or quetiapine fumarate." | 3.83 | Self-harm, Unintentional Injury, and Suicide in Bipolar Disorder During Maintenance Mood Stabilizer Treatment: A UK Population-Based Electronic Health Records Study. ( Geddes, JR; Hayes, JF; King, M; Marston, L; Osborn, DP; Pitman, A; Walters, K, 2016) |
| "Valproic acid (VPA) has been shown to have beneficial properties in lethal hemorrhage/trauma models." | 1.51 | Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Dennahy, IS; Graham, NJ; Kathawate, RG; Li, Y; Russo, RM; Vercruysse, CA; Williams, AM; Zhou, J, 2019) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that may decrease cellular metabolic needs following traumatic injury." | 1.39 | Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury. ( Alam, H; Causey, MW; Hempel, J; Hoffer, Z; Jin, G; Martin, M; Miller, S; Stallings, JD, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Biesterveld, BE | 2 |
| Williams, AM | 2 |
| Kemp, MT | 1 |
| Wakam, GK | 1 |
| Siddiqui, AZ | 1 |
| O'Connell, RL | 1 |
| Shamshad, A | 1 |
| Chtraklin, K | 2 |
| Bhatti, UF | 2 |
| Li, Y | 2 |
| Alam, HB | 2 |
| Graham, NJ | 1 |
| Zhou, J | 1 |
| Dennahy, IS | 1 |
| Kathawate, RG | 1 |
| Vercruysse, CA | 1 |
| Russo, RM | 1 |
| Causey, MW | 1 |
| Miller, S | 1 |
| Hoffer, Z | 1 |
| Hempel, J | 1 |
| Stallings, JD | 1 |
| Jin, G | 1 |
| Alam, H | 1 |
| Martin, M | 1 |
| Sillesen, M | 1 |
| Hayes, JF | 1 |
| Pitman, A | 1 |
| Marston, L | 1 |
| Walters, K | 1 |
| Geddes, JR | 1 |
| King, M | 1 |
| Osborn, DP | 1 |
| Cotton, BA | 1 |
2 reviews available for valproic acid and Injuries
| Article | Year |
|---|---|
Coagulation changes following traumatic brain injury and shock.
Topics: Animals; Blood Coagulation; Brain Injuries; Disease Models, Animal; Humans; Platelet Activation; Sho | 2014 |
Alternative fluids for prehospital resuscitation: "pharmacological" resuscitation fluids.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Emergency Medical Services; Enzyme Inhibito | 2011 |
4 other studies available for valproic acid and Injuries
| Article | Year |
|---|---|
Valproic acid decreases resuscitation requirements after hemorrhage in a prolonged damage-control resuscitation model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Resuscitation; Shock, Hemorrhagic; Swine; V | 2020 |
Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Resuscitation; Sh | 2019 |
Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.
Topics: Acidosis; Animals; Disease Models, Animal; Epinephrine; Hemorrhage; Histone Deacetylase Inhibitors; | 2013 |
Self-harm, Unintentional Injury, and Suicide in Bipolar Disorder During Maintenance Mood Stabilizer Treatment: A UK Population-Based Electronic Health Records Study.
Topics: Adult; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Cohort Studies; Cross-Sectional Studies; | 2016 |