valproic acid has been researched along with Injuries, Spinal Cord in 29 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI." | 7.88 | Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. ( Chen, S; Chen, X; Fu, H; Li, S; Li, Y; Lin, W; Shi, J; Wu, W; Ye, J, 2018) |
| "To examine the effect of combined method on enhancing gene expression, we compared neuronal cell-inducible luciferase levels under normoxia or hypoxia conditions in induced neural stem cells with valproic acid." | 3.96 | Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions. ( Baek, D; Cheong, E; Ha, Y; Kim, J; Lee, D; Oh, J; Yun, Y, 2020) |
| " There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI." | 3.88 | Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. ( Chen, S; Chen, X; Fu, H; Li, S; Li, Y; Lin, W; Shi, J; Wu, W; Ye, J, 2018) |
| "Chronic central pain is a frequent complication after spinal cord injury." | 2.67 | Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study. ( Andreasen, A; Drewes, AM; Poulsen, LH, 1994) |
| "Valproic acid (VPA) is a drug recently has been appreciated for its neuroprotective and neurotrophic properties in various SCI models." | 1.46 | Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture. ( Dargahi, L; Nabiuni, M; Pandamooz, S; Salehi, MS, 2017) |
| "After moderate spinal cord contusion injury at T9, VPA (300 mg/kg) were immediately injected subcutaneously and further injected every 12 h for 5 days." | 1.38 | Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury. ( Choi, HY; Ju, BG; Kim, HS; Lee, JY; Oh, TH; Yune, TY, 2012) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor." | 1.38 | Effects of valproic acid, a histone deacetylase inhibitor, on improvement of locomotor function in rat spinal cord injury based on epigenetic science. ( Abdanipour, A; Schluesener, HJ; Tiraihi, T, 2012) |
| "Treatment with valproic acid greatly diminished the frequency of myoclonic jerks with minimal side effects." | 1.30 | Spinal myoclonus complicating spasticity in spinal cord injury: a case study. ( Andary, MT; Green, DF; Hulce, VD; Pysh, JJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (65.52) | 24.3611 |
| 2020's | 8 (27.59) | 2.80 |
| Authors | Studies |
|---|---|
| Ulas, M | 1 |
| Argadal, OG | 1 |
| Yun, Y | 1 |
| Baek, D | 1 |
| Lee, D | 1 |
| Cheong, E | 1 |
| Kim, J | 1 |
| Oh, J | 1 |
| Ha, Y | 1 |
| Reis, KP | 1 |
| Sperling, LE | 1 |
| Teixeira, C | 1 |
| Sommer, L | 1 |
| Colombo, M | 1 |
| Koester, LS | 1 |
| Pranke, P | 1 |
| Wang, D | 2 |
| Wang, K | 2 |
| Liu, Z | 2 |
| Wang, Z | 2 |
| Wu, H | 3 |
| Hendrix, S | 1 |
| Sanchez, S | 1 |
| Ventriglia, E | 1 |
| Lemmens, S | 1 |
| Zhou, C | 1 |
| Hu, S | 1 |
| Botchway, BOA | 1 |
| Zhang, Y | 1 |
| Liu, X | 1 |
| Mardi, A | 1 |
| Biglar, A | 1 |
| Nejatbakhsh, R | 1 |
| Abdanipour, A | 3 |
| Chen, S | 2 |
| Ye, J | 1 |
| Chen, X | 1 |
| Shi, J | 1 |
| Wu, W | 1 |
| Lin, W | 2 |
| Li, Y | 1 |
| Fu, H | 1 |
| Li, S | 1 |
| Pandamooz, S | 3 |
| Salehi, MS | 3 |
| Zibaii, MI | 1 |
| Safari, A | 2 |
| Nabiuni, M | 2 |
| Ahmadiani, A | 2 |
| Dargahi, L | 3 |
| Azarpira, N | 1 |
| Heravi, M | 1 |
| Lu, WH | 1 |
| Wang, CY | 1 |
| Chen, PS | 1 |
| Wang, JW | 1 |
| Chuang, DM | 1 |
| Yang, CS | 1 |
| Tzeng, SF | 1 |
| Wu, D | 1 |
| Li, Q | 1 |
| Zhu, X | 1 |
| Wu, G | 1 |
| Cui, S | 1 |
| Hao, HH | 1 |
| Wang, L | 1 |
| Guo, ZJ | 1 |
| Bai, L | 1 |
| Zhang, RP | 1 |
| Shuang, WB | 1 |
| Jia, YJ | 1 |
| Wang, J | 1 |
| Li, XY | 1 |
| Liu, Q | 1 |
| Lee, JY | 2 |
| Maeng, S | 1 |
| Kang, SR | 1 |
| Choi, HY | 2 |
| Oh, TH | 2 |
| Ju, BG | 2 |
| Yune, TY | 2 |
| Klebe, D | 1 |
| Hong, Y | 1 |
| Zhang, J | 1 |
| Chen, L | 1 |
| Cui, X | 1 |
| Wu, Z | 1 |
| Jia, L | 1 |
| Yu, Y | 1 |
| Zhou, Q | 1 |
| Hu, X | 1 |
| Xu, W | 1 |
| Luo, D | 1 |
| Liu, J | 1 |
| Xiao, J | 1 |
| Yan, Q | 1 |
| Cheng, L | 1 |
| Schluesener, HJ | 2 |
| Tiraihi, T | 3 |
| Noori-Zadeh, A | 1 |
| Darvishi, M | 1 |
| Mesbah-Namin, SA | 1 |
| Delshad, A | 1 |
| Taheri, T | 1 |
| Chu, T | 1 |
| Zhou, H | 1 |
| Lu, L | 1 |
| Kong, X | 1 |
| Wang, T | 1 |
| Pan, B | 1 |
| Feng, S | 1 |
| Chu, W | 1 |
| Yuan, J | 1 |
| Huang, L | 1 |
| Xiang, X | 1 |
| Zhu, H | 1 |
| Chen, F | 1 |
| Chen, Y | 1 |
| Lin, J | 1 |
| Feng, H | 1 |
| Penas, C | 1 |
| Verdú, E | 1 |
| Asensio-Pinilla, E | 1 |
| Guzmán-Lenis, MS | 1 |
| Herrando-Grabulosa, M | 1 |
| Navarro, X | 1 |
| Casas, C | 1 |
| Lv, L | 2 |
| Sun, Y | 2 |
| Han, X | 2 |
| Xu, CC | 1 |
| Tang, YP | 1 |
| Dong, Q | 2 |
| Wang, X | 1 |
| Kim, HS | 1 |
| Drewes, AM | 1 |
| Andreasen, A | 1 |
| Poulsen, LH | 1 |
| Andary, MT | 1 |
| Green, DF | 1 |
| Hulce, VD | 1 |
| Pysh, JJ | 1 |
3 reviews available for valproic acid and Injuries, Spinal Cord
| Article | Year |
|---|---|
Valproic Acid: A Potential Therapeutic for Spinal Cord Injury.
Topics: Animals; Autophagy; Recovery of Function; Spinal Cord; Spinal Cord Injuries; TOR Serine-Threonine Ki | 2021 |
Valproic acid: a new candidate of therapeutic application for the acute central nervous system injuries.
Topics: Animals; Brain Injuries; Female; Humans; Male; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Val | 2014 |
Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential.
Topics: Animals; Cell Death; Clinical Trials as Topic; Densitometry; Enzyme Inhibitors; Glycogen Synthase Ki | 2015 |
1 trial available for valproic acid and Injuries, Spinal Cord
| Article | Year |
|---|---|
Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Humans; M | 1994 |
25 other studies available for valproic acid and Injuries, Spinal Cord
| Article | Year |
|---|---|
Trace element, antioxidant and oxidant levels in spinal cord injury: different perspective on the effects of valproic acid.
Topics: Animals; Antioxidants; Neuroprotective Agents; Oxidants; Rats; Rats, Sprague-Dawley; Spinal Cord; Sp | 2023 |
Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions.
Topics: Cell Survival; Cell Transplantation; Gene Expression; Genetic Therapy; Humans; Hypoxia; Luciferases; | 2020 |
VPA/PLGA microfibers produced by coaxial electrospinning for the treatment of central nervous system injury.
Topics: Animals; Central Nervous System; Disease Models, Animal; Male; Materials Testing; Microfibrils; Micr | 2020 |
Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury.
Topics: Animals; Chitosan; Male; Nanoparticles; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cor | 2020 |
HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery.
Topics: Animals; Anti-Inflammatory Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic | 2020 |
Valproic Acid Labeled Chitosan Nanoparticles Promote the Proliferation and Differentiation of Neural Stem Cells After Spinal Cord Injury.
Topics: Animals; Cell Differentiation; Cell Proliferation; Chitosan; Locomotion; Male; Nanoparticles; Neural | 2021 |
Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression.
Topics: Animals; Female; Gene Expression; Locomotion; NF-E2-Related Factor 2; Protein Serine-Threonine Kinas | 2021 |
Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Blood-Brain Barrier; Calcium-Binding Proteins; Capi | 2018 |
Modeling traumatic injury in organotypic spinal cord slice culture obtained from adult rat.
Topics: Animals; Brain-Derived Neurotrophic Factor; Gene Expression Regulation; Humans; Male; Neurons; Organ | 2019 |
Enhancing the expression of neurotrophic factors in epidermal neural crest stem cells by valproic acid: A potential candidate for combinatorial treatment.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Movement; Cell Proliferation; Combined Modality The | 2019 |
Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia.
Topics: Animals; Catalase; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expressi | 2013 |
Valproic acid protection against the brachial plexus root avulsion-induced death of motoneurons in rats.
Topics: Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neuropathies; Cell Death; Cells, Cul | 2013 |
Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Disease Models, Anim | 2013 |
Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury.
Topics: Animals; Cell Death; Cytochromes c; Endoplasmic Reticulum Stress; JNK Mitogen-Activated Protein Kina | 2014 |
Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; R | 2014 |
Systemic administration of valproic acid stimulates overexpression of microtubule-associated protein 2 in the spinal cord injury model to promote neurite outgrowth.
Topics: Animals; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Immunohistochemistry; Micro | 2015 |
Decreased GFAP expression and improved functional recovery in contused spinal cord of rats following valproic acid therapy.
Topics: Animals; Blood-Brain Barrier; Glial Fibrillary Acidic Protein; Rats; Spinal Cord; Spinal Cord Injuri | 2014 |
Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Doublecortin Protein; Gene Expre | 2015 |
Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture.
Topics: Animals; Antigens, Nuclear; Cell Death; Cells, Cultured; Motor Neurons; Nerve Tissue Proteins; Neuro | 2017 |
Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury.
Topics: Animals; Axons; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic Reticulum | 2011 |
Valproic acid improves outcome after rodent spinal cord injury: potential roles of histone deacetylase inhibition.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Histone Deacetylase 1; Histone Deacetyla | 2011 |
Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro.
Topics: Animals; Axons; Female; Motor Activity; Neurons; Rats; Rats, Wistar; Spinal Cord Injuries; Valproic | 2012 |
Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury.
Topics: Animals; Blotting, Western; Capillary Permeability; Enzyme-Linked Immunosorbent Assay; Histone Deace | 2012 |
Effects of valproic acid, a histone deacetylase inhibitor, on improvement of locomotor function in rat spinal cord injury based on epigenetic science.
Topics: Animals; Brain-Derived Neurotrophic Factor; Contusions; Cytokines; Ectodysplasins; Epigenesis, Genet | 2012 |
Spinal myoclonus complicating spasticity in spinal cord injury: a case study.
Topics: Activities of Daily Living; Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalograph | 1997 |