valproic acid has been researched along with Injuries, Radiation in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) treatment protected hippocampal neurons from radiation-induced damage in both cell culture and animal models." | 5.42 | Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells. ( DeWees, TA; Engelbach, JA; Garbow, JR; Hallahan, AN; Hallahan, DE; Karvas, RM; Laszlo, A; Thotala, D, 2015) |
| " The effects of HDAC inhibitors in promoting the healing of wounds caused by radiation and in decreasing later skin fibrosis and tumorigenesis were correlated with suppression of the aberrant expression of radiation-induced transforming growth factor beta and tumor necrosis factor alpha." | 3.72 | Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. ( Chung, YL; Wang, AJ; Yao, LF, 2004) |
| "Valproic acid (VPA) treatment protected hippocampal neurons from radiation-induced damage in both cell culture and animal models." | 1.42 | Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells. ( DeWees, TA; Engelbach, JA; Garbow, JR; Hallahan, AN; Hallahan, DE; Karvas, RM; Laszlo, A; Thotala, D, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qu, M | 1 |
| Xiong, L | 1 |
| Lyu, Y | 1 |
| Zhang, X | 1 |
| Shen, J | 1 |
| Guan, J | 1 |
| Chai, P | 1 |
| Lin, Z | 1 |
| Nie, B | 1 |
| Li, C | 1 |
| Xu, J | 1 |
| Deng, H | 1 |
| Park, M | 1 |
| Kwon, J | 1 |
| Youk, H | 1 |
| Shin, US | 1 |
| Han, YH | 1 |
| Kim, Y | 1 |
| Thotala, D | 1 |
| Karvas, RM | 1 |
| Engelbach, JA | 1 |
| Garbow, JR | 1 |
| Hallahan, AN | 1 |
| DeWees, TA | 1 |
| Laszlo, A | 1 |
| Hallahan, DE | 1 |
| Chung, YL | 1 |
| Wang, AJ | 1 |
| Yao, LF | 1 |
4 other studies available for valproic acid and Injuries, Radiation
| Article | Year |
|---|---|
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration.
Topics: Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Colitis; Culture Media, Conditioned; Dextr | 2021 |
Valproic acid protects intestinal organoids against radiation via NOTCH signaling.
Topics: Animals; Humans; Male; Mice; Mice, Inbred C57BL; Neoplasms; Organoids; Protective Agents; Radiation | 2021 |
Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cranial Irradiation; | 2015 |
Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy.
Topics: Acetylation; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Line, Tumor | 2004 |