valproic acid has been researched along with Injuries, Multiple in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 8.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma." | 5.48 | Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. ( Alam, HB; Athey, B; Chtraklin, K; Eidy, H; Georgoff, PE; Ghandour, MH; Higgins, G; Nikolian, VC; Williams, A, 2018) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0." | 5.46 | Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017) |
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 4.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| "We have demonstrated previously that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival in lethal models of hemorrhagic shock." | 3.75 | Surviving blood loss without blood transfusion in a swine poly-trauma model. ( Alam, HB; Butt, MU; Demoya, M; Duggan, M; Fukudome, EY; Li, Y; Liu, B; Shuja, F; Velmahos, GC; Zacharias, N, 2009) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma." | 1.48 | Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. ( Alam, HB; Athey, B; Chtraklin, K; Eidy, H; Georgoff, PE; Ghandour, MH; Higgins, G; Nikolian, VC; Williams, A, 2018) |
| "Valproic acid (VPA) has been associated with improved outcomes in multiple models of trauma, when combined with isotonic fluid resuscitation." | 1.46 | Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock. ( Alam, HB; Dennahy, IS; Duan, X; Duggan, MJ; Georgoff, PE; Li, Y; Liu, B; Mesar, T; Nikolian, VC; Pan, B; Wu, X, 2017) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0." | 1.46 | Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017) |
| "In a clinically relevant lethal polytrauma model, administration of SDP significantly improves survival without any long-term organ dysfunction or complications." | 1.37 | Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model. ( Alam, HB; Bramos, A; Chong, W; Duggan, M; Fikry, K; Fukudome, EY; Hamwi, KB; Kim, K; Lu, J; Velmahos, G, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Biesterveld, BE | 3 |
| Williams, AM | 3 |
| Pai, MP | 2 |
| Dennahy, IS | 4 |
| Graham, NJ | 1 |
| Chtraklin, K | 3 |
| Siddiqui, AZ | 2 |
| OʼConnell, RL | 1 |
| Bhatti, UF | 2 |
| Liu, B | 4 |
| Russo, RM | 1 |
| Li, Y | 5 |
| Alam, HB | 8 |
| O'Connell, RL | 1 |
| Remmer, H | 1 |
| Shamshad, A | 1 |
| Smith, WM | 1 |
| Kemp, MT | 1 |
| Wakam, GK | 1 |
| Nikolian, VC | 4 |
| Pan, B | 1 |
| Mesar, T | 1 |
| Georgoff, PE | 3 |
| Duan, X | 1 |
| Wu, X | 1 |
| Duggan, MJ | 1 |
| Eidy, H | 2 |
| Ghandour, MH | 2 |
| Han, Y | 1 |
| Srinivasan, A | 1 |
| Higgins, G | 1 |
| Williams, A | 1 |
| Athey, B | 1 |
| Chang, P | 1 |
| Lee, J | 1 |
| Shuja, F | 1 |
| Butt, MU | 1 |
| Duggan, M | 2 |
| Zacharias, N | 1 |
| Fukudome, EY | 2 |
| Demoya, M | 1 |
| Velmahos, GC | 1 |
| Hamwi, KB | 1 |
| Fikry, K | 1 |
| Lu, J | 1 |
| Chong, W | 1 |
| Bramos, A | 1 |
| Kim, K | 1 |
| Velmahos, G | 1 |
8 other studies available for valproic acid and Injuries, Multiple
| Article | Year |
|---|---|
Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage, and multiple trauma in swine.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; Erythr | 2019 |
Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
Topics: Acute Kidney Injury; Animals; Creatinine; Drug Evaluation, Preclinical; Hemorrhage; Histone Deacetyl | 2021 |
Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.
Topics: Animals; Caveolin 1; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Lung I | 2017 |
Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cognition; Disease Models, Animal; Enzyme Inhibitors; Fem | 2017 |
Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Female; GABA Agents; Multiple Trauma; Polymerase Chain Reaction; Ra | 2018 |
Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase I | 2019 |
Surviving blood loss without blood transfusion in a swine poly-trauma model.
Topics: Animals; beta Catenin; Blood Pressure; Blood Transfusion; Female; Femoral Fractures; Glycogen Syntha | 2009 |
Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model.
Topics: Analysis of Variance; Animals; Blood Proteins; Blood Transfusion; Disease Models, Animal; Hemostasis | 2011 |