valproic acid has been researched along with Inflammation in 63 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 8.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 7.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| " In this study, we examined the effects of LEV on neuroinflammation and phagocytic microglia in vivo and in vitro and compared the effects of LEV with those of representative antiepileptic drugs valproate (VPA) and carbamazepine (CBZ)." | 7.91 | Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine. ( Ishihara, Y; Itoh, K; Matsuo, T; Oguro, A; Taniguchi, R; Vogel, CFA; Yamazaki, T, 2019) |
| "Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs)." | 7.88 | Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. ( Hajizadeh Moghaddam, A; Khalaj, R; Zare, M, 2018) |
| " There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI." | 7.88 | Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. ( Chen, S; Chen, X; Fu, H; Li, S; Li, Y; Lin, W; Shi, J; Wu, W; Ye, J, 2018) |
| " Valproic acid (VPA) is an inhibitor of PE and could possibly have an effect on the severity of chronic inflammation." | 7.80 | Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. ( Abdul Roda, M; Blalock, JE; Braber, S; Folkerts, G; Gaggar, A; Hardison, MT; Jablonsky, MJ; Jackson, PL; Redegeld, FA; Sadik, M, 2014) |
| " In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis." | 7.79 | Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. ( Geers, C; Mannaerts, I; Pauwels, M; Van Beneden, K; Van den Branden, C; van Grunsven, LA; Wissing, KM, 2013) |
| "In conclusion, thymol improved autism-like behaviours in VPA-induced ASD rats by reducing inflammation and improving neurodevelopment." | 5.91 | Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway. ( Chen, J; Li, Y; Lv, M; Tang, B; Wang, F; Xiong, Y; Zhang, H, 2023) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 5.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 5.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 5.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 5.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-inflammatory, neuro-protective and axon remodeling effects." | 5.38 | Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats. ( Schluesener, HJ; Wu, Y; Zhang, Z; Zhang, ZY, 2012) |
| "Airway inflammation was assessed by bronchoalveolar lavage fluid cell counts and examination of lung tissue sections." | 5.37 | Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. ( Dang, W; De Sampayo, N; El-Osta, A; Karagiannis, TC; Royce, SG; Tang, ML; Ververis, K, 2011) |
| "Valproic acid (VPA) is a short-chain branched fatty with anti-inflammatory, neuro-protective and axon-remodeling effects." | 5.35 | Valproic acid attenuates inflammation in experimental autoimmune neuritis. ( Fauser, U; Schluesener, HJ; Zhang, Z; Zhang, ZY, 2008) |
| " As part of a large double-blind, placebo-controlled clinical trial evaluating the use of valproic acid for prophylaxis of post-traumatic seizures, we obtained extensive valproic acid concentration-time data." | 5.12 | Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury. ( Anderson, GD; Awan, AB; Temkin, NR; Winn, HR; Winn, RH, 2007) |
| "Mice in the HFD group displayed more severe albuminuria, glomerular hypertrophy, renal oxidative damage, inflammation, and lipid accumulation than mice with the normal diet (ND) group, as well as lower levels of intestinal SCFA valproic acid, colonic inflammation, and tight junction protein downregulation." | 4.31 | ACT001 Alleviates chronic kidney injury induced by a high-fat diet in mice through the GPR43/AMPK pathway. ( Chen, Z; Li, P; Li, Y; Liu, J; Mi, Y; Niu, B; Zhou, H; Zhou, Y, 2023) |
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 4.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| " The aim of this study was to evaluate whether VPA can suppress inflammation in bovine mammary epithelial cells (BMECs) stimulated by γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP)." | 3.96 | Sodium valproate attenuates the iE-DAP induced inflammatory response by inhibiting the NOD1-NF-κB pathway and histone modifications in bovine mammary epithelial cells. ( Chang, G; Dai, H; Gao, Q; Ma, N; Roy, AC; Shen, X; Shi, X; Wang, Y, 2020) |
| " In this study, we examined the effects of LEV on neuroinflammation and phagocytic microglia in vivo and in vitro and compared the effects of LEV with those of representative antiepileptic drugs valproate (VPA) and carbamazepine (CBZ)." | 3.91 | Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine. ( Ishihara, Y; Itoh, K; Matsuo, T; Oguro, A; Taniguchi, R; Vogel, CFA; Yamazaki, T, 2019) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 3.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| "Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido-inflammatory stress in Autism Spectrum Disorders (ASDs)." | 3.88 | Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. ( Hajizadeh Moghaddam, A; Khalaj, R; Zare, M, 2018) |
| " There have been no studies that have explained if HDAC inhibition by valproic acid (VPA) affects the NF-κB pathway via acetylation of STAT1 dependent of HDAC activity in the microglia-mediated central inflammation following SCI." | 3.88 | Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. ( Chen, S; Chen, X; Fu, H; Li, S; Li, Y; Lin, W; Shi, J; Wu, W; Ye, J, 2018) |
| "The aim of present study was to investigate the effect of vitamin U (vit U, S-methylmethionine) on oxidative stress, inflammation, and fibrosis within the context of valproic acid (VPA)-induced renal damage." | 3.83 | Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. ( Bolkent, S; Ercin, M; Gezginci-Oktayoglu, S; Turkyilmaz, IB; Yanardag, R, 2016) |
| " Valproic acid (VPA) is an inhibitor of PE and could possibly have an effect on the severity of chronic inflammation." | 3.80 | Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. ( Abdul Roda, M; Blalock, JE; Braber, S; Folkerts, G; Gaggar, A; Hardison, MT; Jablonsky, MJ; Jackson, PL; Redegeld, FA; Sadik, M, 2014) |
| " In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis." | 3.79 | Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. ( Geers, C; Mannaerts, I; Pauwels, M; Van Beneden, K; Van den Branden, C; van Grunsven, LA; Wissing, KM, 2013) |
| "We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response." | 3.78 | Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. ( Alam, HB; Demoya, MA; Duggan, M; Hwabejire, J; Imam, A; Jepsen, CH; Jin, G; Liu, B; Lu, J; Mejaddam, AY; Sillesen, M; Smith, WM; Socrate, S; Velmahos, GC, 2012) |
| " Another set of rats were treated with hydralazine (25 mg/kg per day orally) to determine the pressure-independent effects of HDAC inhibition on hypertension." | 3.76 | HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. ( Cardinale, JP; Elks, CM; Francis, J; Guggilam, A; Mariappan, N; Pariaut, R; Sriramula, S, 2010) |
| "Celecoxib is an effective adjuvant therapy in the treatment of manic episodes (without psychotic features) of bipolar mood disorder." | 2.80 | Celecoxib adjunctive therapy for acute bipolar mania: a randomized, double-blind, placebo-controlled trial. ( Akhondzadeh, S; Ameli, N; Arabzadeh, S; Farokhnia, M; Ghaleiha, A; Mohammadinejad, P; Rezaei, F; Zeinoddini, A, 2015) |
| "Inflammation is thought to be involved in the pathophysiology of bipolar disorder (BP) and metabolic syndrome." | 2.78 | Inflammation's Association with Metabolic Profiles before and after a Twelve-Week Clinical Trial in Drug-Naïve Patients with Bipolar II Disorder. ( Chang, YH; Chen, PS; Chen, SL; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Wang, YS; Yang, YK; Yeh, TL, 2013) |
| "In conclusion, thymol improved autism-like behaviours in VPA-induced ASD rats by reducing inflammation and improving neurodevelopment." | 1.91 | Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway. ( Chen, J; Li, Y; Lv, M; Tang, B; Wang, F; Xiong, Y; Zhang, H, 2023) |
| "Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study has analyzed its efficacy in the clinical setting." | 1.72 | Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19. ( Artero, A; Asensi, V; Asensi-Díaz, E; Blanes, R; Collazos, J; Domingo, P; Dueñas-Gutiérrez, C; Fernández-Araujo, N; Lalueza, A; Lamas-Ferreiro, JL; Ramos-Rincón, JM; Raya-Cruz, M; Roy-Vallejo, E; Sanz-Cánovas, J; Vilchez-Rueda, H, 2022) |
| "Spinal inflammation is a pathophysiological state of neuropathic pain (NP)." | 1.62 | Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response. ( Chen, C; Feng, X; Guo, A; Ke, J; Li, J; Lu, Q; Luo, L, 2021) |
| "Neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (PFC) and cerebellum (CER) of pups." | 1.62 | Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. ( Manjeese, W; Mpofana, T; Mvubu, NE; Steyn, AJC, 2021) |
| "Valproic acid (VPA) has anticancer activity through regulation of cell differentiation and apoptosis via inhibition of histone deacetylase (HDAC) activity and is considered a class I HDAC inhibitor." | 1.48 | Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice. ( Kang, KP; Kim, D; Kim, W; Lee, S; Nguyễn-Thanh, T; Park, SK, 2018) |
| "Renal injury is a hallmark adverse reaction to sodium valproate (SVP), and caffeic acid (CAFF) is a phenolic compound that has anti-inflammatory and antioxsidant properties." | 1.48 | Study on the influence of caffeic acid against sodium valproate-induced nephrotoxicity in rats. ( Gad, AM, 2018) |
| "Using pentylenetetrazole (PTZ)-induced seizures model in mice, the effect of DATS on the anticonvulsant activity of VP was found to be positive, meaning that combination of DATS with VP can confer protection against VP-induced hepatic injurious effects through its antioxidant, antiinflammatory, and antiapoptotic properties without affecting VP antiepileptic activity." | 1.46 | Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy. ( El-Agamy, DS; Shaaban, AA, 2017) |
| "The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded." | 1.46 | Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. ( Al-Shorbagy, MY; Nassar, NN, 2017) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 1.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 1.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 1.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| "CNS inflammation is characterized by a disturbance of glial cell functions." | 1.40 | Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014) |
| "Traumatic brain injuries (TBIs) are a major health care problem worldwide." | 1.40 | Low dose of valproate improves motor function after traumatic brain injury. ( Chiu, WT; Hung, KS; Lee, FP; Lee, WY; Lin, TJ; Shih, CL; Tai, YT; Wang, JY, 2014) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 1.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-inflammatory, neuro-protective and axon remodeling effects." | 1.38 | Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats. ( Schluesener, HJ; Wu, Y; Zhang, Z; Zhang, ZY, 2012) |
| "Airway inflammation was assessed by bronchoalveolar lavage fluid cell counts and examination of lung tissue sections." | 1.37 | Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. ( Dang, W; De Sampayo, N; El-Osta, A; Karagiannis, TC; Royce, SG; Tang, ML; Ververis, K, 2011) |
| "Valproic acid (VPA) is a short-chain branched fatty with anti-inflammatory, neuro-protective and axon-remodeling effects." | 1.35 | Valproic acid attenuates inflammation in experimental autoimmune neuritis. ( Fauser, U; Schluesener, HJ; Zhang, Z; Zhang, ZY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (4.76) | 29.6817 |
| 2010's | 36 (57.14) | 24.3611 |
| 2020's | 24 (38.10) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Luhach, K | 2 |
| Kulkarni, GT | 2 |
| Singh, VP | 2 |
| Sharma, B | 3 |
| Collazos, J | 1 |
| Domingo, P | 1 |
| Fernández-Araujo, N | 1 |
| Asensi-Díaz, E | 1 |
| Vilchez-Rueda, H | 1 |
| Lalueza, A | 1 |
| Roy-Vallejo, E | 1 |
| Blanes, R | 1 |
| Raya-Cruz, M | 1 |
| Sanz-Cánovas, J | 1 |
| Artero, A | 1 |
| Ramos-Rincón, JM | 1 |
| Dueñas-Gutiérrez, C | 1 |
| Lamas-Ferreiro, JL | 1 |
| Asensi, V | 1 |
| Vasconcelos Calheiros de Oliveira Costa, G | 1 |
| Machado Torres, C | 1 |
| Ávila Duarte, J | 1 |
| Peixoto Medeiros, AL | 1 |
| Muxfeldt Bianchin, M | 1 |
| Kandemir, FM | 1 |
| Ileriturk, M | 1 |
| Gur, C | 1 |
| Avolio, E | 1 |
| Olivito, I | 1 |
| Rosina, E | 1 |
| Romano, L | 1 |
| Angelone, T | 1 |
| De Bartolo, A | 1 |
| Scimeca, M | 1 |
| Bellizzi, D | 1 |
| D'Aquila, P | 1 |
| Passarino, G | 1 |
| Alò, R | 1 |
| Facciolo, RM | 1 |
| Bagni, C | 1 |
| De Lorenzo, A | 1 |
| Canonaco, M | 1 |
| Biondo-Simões, R | 4 |
| Biondo-Simões, MLP | 4 |
| Ioshii, SO | 4 |
| Robes, RR | 4 |
| Dall'Antonia, MO | 4 |
| Goehr, MP | 3 |
| Ahlatcı, A | 1 |
| Yıldızhan, K | 1 |
| Tülüce, Y | 1 |
| Bektaş, M | 1 |
| Dutheil, S | 1 |
| Watson, LS | 1 |
| Davis, RE | 1 |
| Snyder, GL | 1 |
| Zheng, Y | 1 |
| Prince, N | 1 |
| van Hattem, C | 1 |
| Garssen, J | 1 |
| Pardo, PP | 1 |
| Kraneveld, AD | 1 |
| Xiong, Y | 1 |
| Chen, J | 1 |
| Lv, M | 1 |
| Wang, F | 1 |
| Zhang, H | 1 |
| Tang, B | 1 |
| Li, Y | 3 |
| Uzel, G | 1 |
| Oylumlu, E | 1 |
| Durmus, L | 1 |
| Ciraci, C | 1 |
| Zhou, Y | 1 |
| Chen, Z | 1 |
| Zhou, H | 2 |
| Niu, B | 1 |
| Liu, J | 1 |
| Mi, Y | 1 |
| Li, P | 1 |
| Gao, Q | 1 |
| Wang, Y | 2 |
| Ma, N | 1 |
| Dai, H | 1 |
| Roy, AC | 1 |
| Chang, G | 1 |
| Shi, X | 1 |
| Shen, X | 1 |
| Gąssowska-Dobrowolska, M | 1 |
| Cieślik, M | 1 |
| Czapski, GA | 1 |
| Jęśko, H | 1 |
| Frontczak-Baniewicz, M | 1 |
| Gewartowska, M | 1 |
| Dominiak, A | 1 |
| Polowy, R | 1 |
| Filipkowski, RK | 1 |
| Babiec, L | 1 |
| Adamczyk, A | 1 |
| Hendrix, S | 1 |
| Sanchez, S | 1 |
| Ventriglia, E | 1 |
| Lemmens, S | 1 |
| A-G, N | 1 |
| Am, EB | 1 |
| Eh, R | 1 |
| Ahmed, RG | 1 |
| Lu, RB | 2 |
| Wang, TY | 2 |
| Lee, SY | 2 |
| Chang, YH | 2 |
| Chen, SL | 2 |
| Tsai, TY | 1 |
| Chen, PS | 2 |
| Huang, SY | 2 |
| Tzeng, NS | 2 |
| Lee, IH | 2 |
| Chen, KC | 1 |
| Yang, YK | 2 |
| Hong, JS | 2 |
| Lefkopoulos, S | 1 |
| Polyzou, A | 1 |
| Derecka, M | 1 |
| Bergo, V | 1 |
| Clapes, T | 1 |
| Cauchy, P | 1 |
| Jerez-Longres, C | 1 |
| Onishi-Seebacher, M | 1 |
| Yin, N | 1 |
| Martagon-Calderón, NA | 1 |
| Potts, KS | 1 |
| Klaeylé, L | 1 |
| Liu, F | 1 |
| Bowman, TV | 1 |
| Jenuwein, T | 1 |
| Mione, MC | 1 |
| Trompouki, E | 1 |
| Guo, A | 1 |
| Li, J | 1 |
| Luo, L | 1 |
| Chen, C | 1 |
| Lu, Q | 1 |
| Ke, J | 1 |
| Feng, X | 1 |
| Kühne, M | 1 |
| Kretzer, C | 1 |
| Lindemann, H | 1 |
| Godmann, M | 1 |
| Heinze, T | 1 |
| Werz, O | 1 |
| Heinzel, T | 1 |
| Manjeese, W | 1 |
| Mvubu, NE | 1 |
| Steyn, AJC | 1 |
| Mpofana, T | 1 |
| Celik, E | 1 |
| Tunali, S | 1 |
| Gezginci-Oktayoglu, S | 2 |
| Bolkent, S | 2 |
| Can, A | 1 |
| Yanardag, R | 2 |
| Shaaban, AA | 1 |
| El-Agamy, DS | 1 |
| Costalonga, EC | 1 |
| de Freitas, LJ | 1 |
| Aragone, DDSP | 1 |
| Silva, FMO | 1 |
| Noronha, IL | 1 |
| Nguyễn-Thanh, T | 1 |
| Kim, D | 1 |
| Lee, S | 1 |
| Kim, W | 1 |
| Park, SK | 1 |
| Kang, KP | 1 |
| Liu, Q | 1 |
| Li, H | 1 |
| Yang, J | 1 |
| Niu, X | 1 |
| Zhao, C | 1 |
| Zhao, L | 1 |
| Wang, Z | 1 |
| Chen, S | 1 |
| Ye, J | 1 |
| Chen, X | 1 |
| Shi, J | 1 |
| Wu, W | 1 |
| Lin, W | 2 |
| Fu, H | 1 |
| Li, S | 1 |
| Khalaj, R | 1 |
| Hajizadeh Moghaddam, A | 1 |
| Zare, M | 1 |
| Gad, AM | 1 |
| Mirza, R | 1 |
| Itoh, K | 1 |
| Taniguchi, R | 1 |
| Matsuo, T | 1 |
| Oguro, A | 1 |
| Vogel, CFA | 1 |
| Yamazaki, T | 1 |
| Ishihara, Y | 2 |
| Suda, S | 1 |
| Katsura, K | 1 |
| Kanamaru, T | 1 |
| Saito, M | 1 |
| Katayama, Y | 1 |
| Van Beneden, K | 1 |
| Geers, C | 1 |
| Pauwels, M | 1 |
| Mannaerts, I | 1 |
| Wissing, KM | 1 |
| Van den Branden, C | 1 |
| van Grunsven, LA | 1 |
| Wang, YS | 1 |
| Wang, LJ | 1 |
| Yeh, TL | 1 |
| Ji, MH | 1 |
| Li, GM | 1 |
| Jia, M | 1 |
| Zhu, SH | 1 |
| Gao, DP | 1 |
| Fan, YX | 1 |
| Wu, J | 1 |
| Yang, JJ | 1 |
| Neuman, MG | 1 |
| Nanau, RM | 1 |
| Shekh-Ahmad, T | 1 |
| Yagen, B | 2 |
| Bialer, M | 2 |
| Dambach, H | 1 |
| Hinkerohe, D | 1 |
| Prochnow, N | 1 |
| Stienen, MN | 1 |
| Moinfar, Z | 1 |
| Haase, CG | 1 |
| Hufnagel, A | 1 |
| Faustmann, PM | 1 |
| Tai, YT | 1 |
| Lee, WY | 1 |
| Lee, FP | 1 |
| Lin, TJ | 1 |
| Shih, CL | 1 |
| Wang, JY | 1 |
| Chiu, WT | 1 |
| Hung, KS | 1 |
| Abdul Roda, M | 1 |
| Sadik, M | 1 |
| Gaggar, A | 1 |
| Hardison, MT | 1 |
| Jablonsky, MJ | 1 |
| Braber, S | 1 |
| Blalock, JE | 1 |
| Redegeld, FA | 1 |
| Folkerts, G | 1 |
| Jackson, PL | 1 |
| Chu, T | 1 |
| Lu, L | 1 |
| Kong, X | 1 |
| Wang, T | 1 |
| Pan, B | 1 |
| Feng, S | 1 |
| Wu, SY | 1 |
| Tang, SE | 1 |
| Ko, FC | 1 |
| Wu, GC | 1 |
| Huang, KL | 1 |
| Chu, SJ | 1 |
| Turkyilmaz, IB | 1 |
| Ercin, M | 1 |
| Arabzadeh, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Series Studies of Bipolar Disorder-Valproate add-on Memantine Treatment[NCT01188148] | Phase 2/Phase 3 | 219 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Inflammation
| Article | Year |
|---|---|
Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential.
Topics: Animals; Cell Death; Clinical Trials as Topic; Densitometry; Enzyme Inhibitors; Glycogen Synthase Ki | 2015 |
The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders.
Topics: Animals; Autism Spectrum Disorder; Benzhydryl Compounds; Brain; Diethylhexyl Phthalate; Disease Mode | 2017 |
4 trials available for valproic acid and Inflammation
| Article | Year |
|---|---|
Add-on memantine may improve cognitive functions and attenuate inflammation in middle- to old-aged bipolar II disorder patients.
Topics: Aged; Bipolar Disorder; Cognition; Double-Blind Method; Drug Therapy, Combination; Humans; Inflammat | 2021 |
Inflammation's Association with Metabolic Profiles before and after a Twelve-Week Clinical Trial in Drug-Naïve Patients with Bipolar II Disorder.
Topics: Adult; Biomarkers; Bipolar Disorder; Cytokines; Double-Blind Method; Drug Therapy, Combination; Fema | 2013 |
Celecoxib adjunctive therapy for acute bipolar mania: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Bipolar Disorder; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, | 2015 |
Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries; Craniotomy; Cytokines; | 2007 |
57 other studies available for valproic acid and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Brain; Ci | 2021 |
Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19.
Topics: Aged; Blood Cell Count; COVID-19; COVID-19 Drug Treatment; Female; Hospitalization; Humans; Inflamma | 2022 |
Valproate-Induced Reversible Hemichoreoathetosis in a Patient With Rasmussen Encephalitis.
Topics: Encephalitis; Humans; Inflammation; Magnetic Resonance Imaging; Valproic Acid | 2022 |
Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy.
Topics: Animals; Apoptosis; Autophagy; Biomarkers; Humans; Inflammation; Kidney; Kidney Diseases; Liver; Oxi | 2022 |
Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Child; Disease Models, Animal; Female; Humans; | 2022 |
The effects of valproic acid on skin healing: experimental study in rats.
Topics: Animals; Collagen; Collagen Type I; Inflammation; Male; Myofibroblasts; Rats; Rats, Wistar; Valproic | 2022 |
Valproic acid and bladder healing: an experimental study in rats.
Topics: Animals; Inflammation; Male; Rats; Rats, Wistar; Urinary Bladder; Valproic Acid; Wound Healing | 2022 |
Valproic acid and bladder healing: an experimental study in rats.
Topics: Animals; Inflammation; Male; Rats; Rats, Wistar; Urinary Bladder; Valproic Acid; Wound Healing | 2022 |
Valproic acid and bladder healing: an experimental study in rats.
Topics: Animals; Inflammation; Male; Rats; Rats, Wistar; Urinary Bladder; Valproic Acid; Wound Healing | 2022 |
Valproic acid and bladder healing: an experimental study in rats.
Topics: Animals; Inflammation; Male; Rats; Rats, Wistar; Urinary Bladder; Valproic Acid; Wound Healing | 2022 |
Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel.
Topics: Apoptosis; Humans; Inflammation; Neuroblastoma; Oxidative Stress; Pentylenetetrazole; TRPM Cation Ch | 2022 |
Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation.
Topics: Animals; Cytokines; Depressive Disorder, Major; Female; Inflammation; Lithium; Male; Mammals; Mice; | 2023 |
The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Inflammation; Mice; PTEN Phosphohydrolase | 2023 |
Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Inflam | 2023 |
Duality of Valproic Acid Effects on Inflammation, Oxidative Stress and Autophagy in Human Eosinophilic Cells.
Topics: Antioxidants; Autophagy; Humans; Hypersensitivity; Inflammation; Oxidative Stress; Valproic Acid | 2023 |
ACT001 Alleviates chronic kidney injury induced by a high-fat diet in mice through the GPR43/AMPK pathway.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Female; Inflammation; Kelch-Like ECH-Associa | 2023 |
Sodium valproate attenuates the iE-DAP induced inflammatory response by inhibiting the NOD1-NF-κB pathway and histone modifications in bovine mammary epithelial cells.
Topics: Acetylation; Animals; Apoptosis; Autophagy; Cattle; Cells, Cultured; Diaminopimelic Acid; Epithelial | 2020 |
Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Brain; Female; Inflammation; M | 2020 |
HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery.
Topics: Animals; Anti-Inflammatory Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic | 2020 |
Maternal Sodium Valproate Exposure Alters Neuroendocrine-Cytokines and Oxido-inflammatory Axes in Neonatal Albino Rats.
Topics: Animals; Animals, Newborn; Cytokines; Female; Inflammation; Maternal Exposure; Neurosecretory System | 2021 |
Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells.
Topics: Animals; Biomarkers; Chromatin Assembly and Disassembly; Disease Susceptibility; DNA Transposable El | 2020 |
Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response.
Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylases; Inflammation; J | 2021 |
Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation.
Topics: Histone Deacetylase Inhibitors; Humans; Inflammation; Lipopolysaccharides; Nanoparticles; Valproic A | 2021 |
Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring.
Topics: Adult; Animals; Astrocytes; Autism Spectrum Disorder; Blood-Brain Barrier; Cell Count; Cerebellum; F | 2021 |
Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Disease Models, Animal; Doublecorti | 2021 |
Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Chemical and Drug Induced Liver Injury, Chroni | 2021 |
Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy.
Topics: Allyl Compounds; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apoptosis; Chemic | 2017 |
Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis.
Topics: Animals; Biological Transport; Biomarkers; Body Weight; Bone Morphogenetic Protein 7; Calcium-Bindin | 2017 |
Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice.
Topics: Animals; Cell Proliferation; Extracellular Matrix Proteins; Fibrosis; Histone Deacetylase 1; Histone | 2018 |
Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis.
Topics: Animals; Apoptosis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; In Situ Nic | 2017 |
Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Blood-Brain Barrier; Calcium-Binding Proteins; Capi | 2018 |
Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism.
Topics: Animals; Anticonvulsants; Antioxidants; Autistic Disorder; Birth Weight; Brain Chemistry; Cytokines; | 2018 |
Study on the influence of caffeic acid against sodium valproate-induced nephrotoxicity in rats.
Topics: Animals; Anticonvulsants; Biomarkers; Caffeic Acids; Caspase 3; Creatinine; Inflammation; Interferon | 2018 |
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Br | 2019 |
Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine.
Topics: Animals; Anticonvulsants; Carbamazepine; Cells, Cultured; Cytokines; Inflammation; Levetiracetam; Ma | 2019 |
Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Brain Ischemia; Disease Models, Animal; In Situ Nic | 2013 |
Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis.
Topics: Acetylation; Animals; Doxorubicin; Female; Fibrosis; Glomerulosclerosis, Focal Segmental; Histone De | 2013 |
Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Bronchoalveolar Lavage Fluid; Do | 2013 |
Valproic acid derivatives signal for apoptosis and repair in vitro.
Topics: Amides; Apoptosis; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA Repair; Drug Hypersensitivi | 2013 |
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc | 2014 |
Low dose of valproate improves motor function after traumatic brain injury.
Topics: Acetylation; Animals; Apoptosis; Brain Injuries; Cyclic AMP Response Element-Binding Protein; Dose-R | 2014 |
Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation.
Topics: Animals; Collagen; Female; Humans; Inflammation; Mice; Neutrophils; Nicotiana; Prolyl Oligopeptidase | 2014 |
Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats.
Topics: Acetylation; Acute Lung Injury; Animals; Antioxidants; Body Weight; Capillary Permeability; Heme Oxy | 2015 |
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Catalase; Collagen Type I; Creat | 2016 |
Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Butyrates; Caspase 3; Cell Line; Cell Line, Tumor; Cell Mo | 2016 |
Valproic Acid and Lithium Meditate Anti-Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Arthritis, Experimental; Cattle; Cell Differentiati | 2017 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprote | 2017 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Enzyme-Linked Immunosorbent Assay; Escherichia col | 2017 |
Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Proliferation; Histone Deacetylase Inhibitors; Inflammat | 2017 |
Valproic acid attenuates inflammation in experimental autoimmune neuritis.
Topics: Animals; Cell Count; Cytokines; Forkhead Transcription Factors; Gene Expression Profiling; Inflammat | 2008 |
Influence of NMDA and non-NMDA antagonists on acute and inflammatory pain in the trigeminal territory: a placebo control study.
Topics: Animals; Exploratory Behavior; Facial Pain; Fructose; Inflammation; Male; Memantine; Motor Activity; | 2008 |
Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes.
Topics: Astrocytes; Blotting, Western; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Gene E | 2010 |
HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Echocardiography; Histone Deacetylas | 2010 |
Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Endotoxemia; Flavonoids; HMGB1 Protein; Inflam | 2011 |
Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease.
Topics: Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease | 2011 |
The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Glioblastoma; Histone Deacetylase Inhibitors; Humans; | 2012 |
Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats.
Topics: Animals; Anti-Inflammatory Agents; CD11b Antigen; CD3 Complex; Cell Proliferation; Cytokines; Diseas | 2012 |
Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Female; Hemodynamics; Hy | 2012 |