valproic acid has been researched along with Infertility, Male in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to assess whether, male patients with epilepsy, switching from valproic acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients' female partners to spontaneously conceive." | 3.96 | An open study of valproate in subfertile men with epilepsy. ( Georgiou, I; Kostoulas, C; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| "The effects of the antiepileptic drugs sodium valproate (VPA) and levetiracetam (LEV) on reproductive endocrine function, sexual function, and spermatozoa were explored, together with their possible etiological mechanisms, in Chinese Han men with epilepsy." | 3.79 | Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy. ( Daoliang, X; Hengzhong, Z; Xiaotian, X; Yao, X; Yumei, W; Zhipan, Z, 2013) |
| "Valproic acid (VPA) was the first recognized AED to cause disturbances potentially due to metabolic changes and increasing weight." | 2.66 | Reproductive health in patients with epilepsy. ( Chatzistefanidis, D; Georgiou, I; Keramida, A; Kyritsis, AP; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| "Felbamate (FBM) was initiated and VPA discontinued for improved seizure control." | 1.30 | Male infertility: possible association with valproate exposure. ( McCoy, GB; Yerby, MS, 1999) |
| "We report on 2 cases of oligoasthenoteratozoospermia due to therapy with valproic acid, which had been given on account of mal grand epilepsy in both cases." | 1.27 | [Oligoasthenoteratozoospermia in valproic acid therapy]. ( Falker, G; Krause, W, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Markoula, S | 2 |
| Siarava, E | 2 |
| Keramida, A | 1 |
| Chatzistefanidis, D | 1 |
| Zikopoulos, A | 2 |
| Kyritsis, AP | 1 |
| Georgiou, I | 2 |
| Kostoulas, C | 1 |
| Ganjkhani, M | 1 |
| Nourozi, S | 1 |
| Bigonah, R | 1 |
| Rostami, A | 1 |
| Shokri, S | 1 |
| Xiaotian, X | 1 |
| Hengzhong, Z | 1 |
| Yao, X | 1 |
| Zhipan, Z | 1 |
| Daoliang, X | 1 |
| Yumei, W | 1 |
| Aldemir, E | 1 |
| Arici, Ş | 1 |
| Umul, M | 1 |
| Öztürk, U | 1 |
| Aydin, HH | 1 |
| Çelebisoy, M | 1 |
| Vahip, S | 1 |
| Yerby, MS | 1 |
| McCoy, GB | 1 |
| Bauer, J | 1 |
| Falker, G | 1 |
| Krause, W | 1 |
2 reviews available for valproic acid and Infertility, Male
| Article | Year |
|---|---|
Reproductive health in patients with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Gonadal Steroid Hormones; Humans; Infertility, Female; Infertilit | 2020 |
Epilepsy therapy: issues for women and men.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert | 2001 |
6 other studies available for valproic acid and Infertility, Male
| Article | Year |
|---|---|
An open study of valproate in subfertile men with epilepsy.
Topics: Adult; Anticonvulsants; Drug Substitution; Epilepsy; Female; Greece; Humans; Infertility, Male; Lamo | 2020 |
Ameliorating impacts of ginseng on the apoptosis of spermatogenic cells and sperm quality in temporal lobe epilepsy rat model treated with valproate.
Topics: Animals; Anticonvulsants; Apoptosis; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Infert | 2019 |
Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Erectile Dysfunction; Follicle Stimulati | 2013 |
Abnormal semen parameters in bipolar men treated with valproate.
Topics: Anticonvulsants; Bipolar Disorder; Humans; Infertility, Male; Male; Semen; Valproic Acid | 2012 |
Male infertility: possible association with valproate exposure.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Infertility, | 1999 |
[Oligoasthenoteratozoospermia in valproic acid therapy].
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Humans; Infertility, Male; Male; Ol | 1988 |