valproic acid has been researched along with Infections in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Infections: Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine an optimal biologic dose (OBD) of decitabine as a single agent and then the maximum-tolerated dose (MTD) of valproic acid (VA) combined with decitabine in acute myeloid leukemia (AML)." | 2.73 | Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. ( Blum, W; Byrd, JC; Chan, KK; Devine, H; Devine, SM; Grever, MR; Hackanson, B; Heerema, NA; Huynh, L; Kefauver, C; Klisovic, RB; Liu, S; Liu, Z; Lozanski, G; Marcucci, G; Murgo, A; Plass, C; Vukosavljevic, T, 2007) |
| " This study summarizes 6 cases of drug-drug interactions between VPA and carbapenem antibiotics." | 1.38 | Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. ( Cho, JY; Han, HK; Jang, IJ; Kim, TE; Lim, KS; Park, MK; Shin, KH; Shin, SG; Yi, SJ; Yu, KS, 2012) |
| "Pancreatitis is more common in children than previously thought." | 1.32 | Pancreatitis in children. ( Frautschy, BC; Kugathasan, S; Werlin, SL, 2003) |
| "Two cases are reported who developed myoclonus as the only manifestation of a post-infectious syndrome without evidence of encephalitis or the opsoclonus-myoclonus syndrome." | 1.28 | "Isolated" postinfectious myoclonus. ( Bhatia, K; Marsden, CD; Thompson, PD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, MK | 1 |
| Lim, KS | 1 |
| Kim, TE | 1 |
| Han, HK | 1 |
| Yi, SJ | 1 |
| Shin, KH | 1 |
| Cho, JY | 1 |
| Shin, SG | 1 |
| Jang, IJ | 1 |
| Yu, KS | 1 |
| Werlin, SL | 1 |
| Kugathasan, S | 1 |
| Frautschy, BC | 1 |
| Blum, W | 1 |
| Klisovic, RB | 1 |
| Hackanson, B | 1 |
| Liu, Z | 1 |
| Liu, S | 1 |
| Devine, H | 1 |
| Vukosavljevic, T | 1 |
| Huynh, L | 1 |
| Lozanski, G | 1 |
| Kefauver, C | 1 |
| Plass, C | 1 |
| Devine, SM | 1 |
| Heerema, NA | 1 |
| Murgo, A | 1 |
| Chan, KK | 1 |
| Grever, MR | 1 |
| Byrd, JC | 1 |
| Marcucci, G | 1 |
| Bhatia, K | 1 |
| Thompson, PD | 1 |
| Marsden, CD | 1 |
| Böhles, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study of Decitabine in Combination With Valproic Acid in Patients With Selected Hematologic Malignancies[NCT00079378] | Phase 1 | 84 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| Randomized Phase II Study on Decitabine Plus Carboplatin Versus Physician's Choice Chemotherapy in Recurrent, Platinum-resistant Ovarian Cancer.[NCT03467178] | Phase 2 | 119 participants (Anticipated) | Interventional | 2018-07-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for valproic acid and Infections
| Article | Year |
|---|---|
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Brain D | 2007 |
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Brain D | 2007 |
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Brain D | 2007 |
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Brain D | 2007 |
4 other studies available for valproic acid and Infections
| Article | Year |
|---|---|
Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Carbapenems; Drug Interactions; Drug Monitoring; Fem | 2012 |
Pancreatitis in children.
Topics: Abdominal Pain; Adolescent; Amylases; Biliary Tract Diseases; Child; Child, Preschool; Hospitals, Pe | 2003 |
"Isolated" postinfectious myoclonus.
Topics: Adolescent; Clonazepam; Evoked Potentials, Somatosensory; Female; Humans; Infections; Myoclonus; Pro | 1992 |
[When is parenteral carnitine administration indicated?].
Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Pr | 1986 |