valproic acid has been researched along with Infarction, Middle Cerebral Artery in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries." | 1.91 | Post-stroke seizures: risk factors and management after ischemic stroke. ( Derbali, H; Mansour, M; Messelmani, M; Mrissa, N; Mrissa, R; Ouerdiene, A; Zaouali, J, 2023) |
| "Mice were subjected to middle cerebral artery occlusion (MCAO) model to induce IS injures and then were administrated with VPA." | 1.56 | Valproate improves middle cerebral artery occlusion-induced ischemic cerebral disorders in mice and oxygen-glucose deprivation-induced injuries in microglia by modulating RMRP/PI3K/Akt axis. ( Li, X; Sui, Y, 2020) |
| "Hyperglycemia was induced by streptozotocin (STZ) injection 3 days before." | 1.42 | Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion. ( Abe, A; Aoki, J; Kimura, K; Nishiyama, Y; Nito, C; Okubo, S; Sakamoto, Y; Suda, S; Suzuki, K; Ueda, M, 2015) |
| "Male rats underwent middle cerebral artery occlusion for 60 minutes followed by reperfusion for up to 14 days." | 1.38 | Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke. ( Chibane, F; Chuang, DM; Fessler, EB; Leeds, P; Leng, Y; Munasinghe, J; Tsai, LK; Wang, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Naseh, M | 1 |
| Bayat, M | 1 |
| Akbari, S | 1 |
| Vatanparast, J | 1 |
| Shabani, M | 1 |
| Haghighi, AB | 1 |
| Haghani, M | 1 |
| Li, X | 1 |
| Sui, Y | 1 |
| Ouerdiene, A | 1 |
| Messelmani, M | 1 |
| Derbali, H | 1 |
| Mansour, M | 1 |
| Zaouali, J | 1 |
| Mrissa, N | 1 |
| Mrissa, R | 1 |
| Suda, S | 2 |
| Katsura, KI | 1 |
| Saito, M | 1 |
| Kamiya, N | 1 |
| Katayama, Y | 1 |
| Ueda, M | 1 |
| Nito, C | 1 |
| Nishiyama, Y | 1 |
| Okubo, S | 1 |
| Abe, A | 1 |
| Aoki, J | 1 |
| Suzuki, K | 1 |
| Sakamoto, Y | 1 |
| Kimura, K | 1 |
| Wang, Z | 3 |
| Leng, Y | 3 |
| Tsai, LK | 3 |
| Leeds, P | 3 |
| Chuang, DM | 3 |
| Munasinghe, J | 2 |
| Fessler, EB | 1 |
| Chibane, F | 1 |
8 other studies available for valproic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Neuroprotective effects of sodium valproate on hippocampal cell and volume, and cognitive function in a rat model of focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cognition; Hippocampus; Infarction, Middle Cerebral Artery; Long-Term Poten | 2022 |
Valproate improves middle cerebral artery occlusion-induced ischemic cerebral disorders in mice and oxygen-glucose deprivation-induced injuries in microglia by modulating RMRP/PI3K/Akt axis.
Topics: Animals; Apoptosis; Brain Ischemia; Enzyme Inhibitors; Glucose; Infarction, Middle Cerebral Artery; | 2020 |
Post-stroke seizures: risk factors and management after ischemic stroke.
Topics: Aged; Epilepsy; Female; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Middle Ag | 2023 |
Valproic acid enhances the effect of bone marrow-derived mononuclear cells in a rat ischemic stroke model.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain Ischemia; Combined Modality Therapy; | 2014 |
Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion.
Topics: Animals; Blood Glucose; Brain; Brain Ischemia; Hyperglycemia; Infarction, Middle Cerebral Artery; Ma | 2015 |
Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Butyrates | 2011 |
Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.
Topics: Animals; Cell Movement; Infarction, Middle Cerebral Artery; Lithium; Mesenchymal Stem Cell Transplan | 2011 |
Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain Ischemia; Cerebral Infarction; Hypoxia-Inducible | 2012 |