valproic acid has been researched along with Infant, Newborn, Diseases in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 7.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 7.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 3.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "Fetal Valproate Syndrome results from prenatal exposure to valproic acid." | 3.73 | Fetal valproate syndrome. ( Kulkarni, ML; Shenoy, N; Vani, HN; Zaheeruddin, M, 2006) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 3.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Çoban, D | 1 |
| Kurtoğlu, S | 1 |
| Akın, MA | 1 |
| Akçakuş, M | 1 |
| Güneş, T | 1 |
| Krsek, P | 1 |
| Sebronová, V | 1 |
| Procházka, T | 1 |
| Maulisová, A | 1 |
| Komárek, V | 1 |
| Kulkarni, ML | 1 |
| Zaheeruddin, M | 1 |
| Shenoy, N | 1 |
| Vani, HN | 1 |
| Bjerkedal, T | 1 |
| Czeizel, A | 1 |
| Goujard, J | 1 |
| Kallen, B | 1 |
| Mastroiacova, P | 1 |
| Nevin, N | 1 |
| Oakley, G | 1 |
| Robert, E | 1 |
| Koch, S | 1 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 1 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Andrew, M | 1 |
| Barr, RD | 1 |
| Bruel, H | 1 |
| Chabrolle, JP | 1 |
| Amusini, P | 1 |
| Levesque, L | 1 |
| Iskandar, K | 1 |
| Poinsot, J | 1 |
| Similä, S | 1 |
| von Wendt, L | 1 |
| Hartikainen-Sorri, AL | 1 |
| Kääpä, P | 1 |
| Saukkonen, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Increased platelet destruction in infancy and childhood.
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Animals; Autoimmune Diseases; Blood Platelets; Child; Ch | 1982 |
1 trial available for valproic acid and Infant, Newborn, Diseases
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
6 other studies available for valproic acid and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.
Topics: Anticonvulsants; Epilepsy; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, | 2010 |
Successful treatment of Ohtahara syndrome with chloral hydrate.
Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans; | 2002 |
Fetal valproate syndrome.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; | 2006 |
Valproic acid and spina bifida.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregn | 1982 |
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate].
Topics: Adult; Ammonia; Anticonvulsants; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 2001 |
Sodium valproate, pregnancy, and neonatal hyperglycinaemia.
Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pre | 1979 |