valproic acid has been researched along with Inadequate Sleep in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we developed a novel mania mice model by combining a series of chronic unpredictable rhythm disturbances (CURD), which include disruption of circadian rhythm, sleep deprivation, exposure to cone light, with subsequent interference of followed spotlight, stroboscopic illumination, high-temperature stress, noise disturbance and foot shock." | 1.91 | A novel murine model of mania. ( Chen, B; Cui, L; Feng, Y; Gong, W; Ji, M; Li, B; Li, X; Verkhratsky, A; Wang, S; Wu, X; Xia, M; Zhang, D, 2023) |
| "Low-dose sodium valproate improves sleep deprivation-disrupted sensorimotor gating, and this finding may rationalize the use of sodium valproate in psychotic states and other sensory processing disorders." | 1.62 | Sodium valproate improves sensorimotor gating deficit induced by sleep deprivation at low doses ( Çevreli, B; Kaya-Yertutanol, FD; Kulaksız, H; Özdoğru, AA; Tekin, M; Uzbay, İT, 2021) |
| "A relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown." | 1.42 | A new model to study sleep deprivation-induced seizure. ( Leahy, A; Lucey, BP; Rosas, R; Shaw, PJ, 2015) |
| "Juvenile myoclonic epilepsy is a common, under-recognised form of epilepsy which is best treated with sodium valproate." | 1.29 | Juvenile myoclonic epilepsy: diagnosis, management and outcome. ( Buchanan, N; Sharpe, C, 1995) |
| " During EEG recording of wake-sleep cycle valporoic acid was shown to produce hypnotic action dependent on drug dosage in high active and low active animals." | 1.28 | [The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure]. ( Mdzinarishvili, AL; Molodavkin, GA; Voronina, TA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Chen, B | 1 |
| Zhang, D | 1 |
| Wang, S | 1 |
| Feng, Y | 1 |
| Wu, X | 1 |
| Cui, L | 1 |
| Ji, M | 1 |
| Gong, W | 1 |
| Verkhratsky, A | 1 |
| Xia, M | 1 |
| Li, B | 1 |
| Dal-Pont, GC | 1 |
| Jório, MTS | 1 |
| Resende, WR | 2 |
| Gava, FF | 1 |
| Aguiar-Geraldo, JM | 1 |
| Possamai-Della, T | 1 |
| Peper-Nascimento, J | 1 |
| Quevedo, J | 2 |
| Valvassori, SS | 2 |
| Tekin, M | 1 |
| Kaya-Yertutanol, FD | 1 |
| Çevreli, B | 1 |
| Özdoğru, AA | 1 |
| Kulaksız, H | 1 |
| Uzbay, İT | 1 |
| Xu, L | 1 |
| Guo, D | 1 |
| Liu, YY | 1 |
| Qiao, DD | 1 |
| Ye, JY | 1 |
| Xue, R | 1 |
| Lucey, BP | 1 |
| Leahy, A | 1 |
| Rosas, R | 1 |
| Shaw, PJ | 1 |
| Streck, EL | 1 |
| Scaini, G | 1 |
| Jeremias, GC | 1 |
| Rezin, GT | 1 |
| Gonçalves, CL | 1 |
| Ferreira, GK | 1 |
| Réus, GZ | 1 |
| Kapczinski, F | 1 |
| Andersen, ML | 1 |
| Park, HJ | 1 |
| Kang, WS | 1 |
| Paik, JW | 1 |
| Kim, JW | 1 |
| Sharpe, C | 1 |
| Buchanan, N | 1 |
| Declerck, AC | 2 |
| Wauquier, A | 2 |
| Mdzinarishvili, AL | 1 |
| Molodavkin, GA | 1 |
| Voronina, TA | 1 |
| Burgess, RJ | 1 |
| Drake, ME | 1 |
| Paulson, GW | 1 |
| Martens, WL | 1 |
1 review available for valproic acid and Inadequate Sleep
| Article | Year |
|---|---|
Juvenile myoclonic epilepsy and sleep.
Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy, Reflex; Female; Humans; Male; | 2018 |
11 other studies available for valproic acid and Inadequate Sleep
| Article | Year |
|---|---|
A novel murine model of mania.
Topics: Animals; Bipolar Disorder; Disease Models, Animal; Humans; Mania; Mice; Sleep Deprivation; Valproic | 2023 |
Effects of lithium and valproate on behavioral parameters and neurotrophic factor levels in an animal model of mania induced by paradoxical sleep deprivation.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Di | 2019 |
Sodium valproate improves sensorimotor gating deficit induced by sleep deprivation at low doses
Topics: Animals; Pharmaceutical Preparations; Rats; Rats, Wistar; Reflex, Startle; Sensory Gating; Sleep Dep | 2021 |
A new model to study sleep deprivation-induced seizure.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Disease Susceptibility; Drosophila melanoga | 2015 |
Effects of Mood Stabilizers on Brain Energy Metabolism in Mice Submitted to an Animal Model of Mania Induced by Paradoxical Sleep Deprivation.
Topics: Adenosine Triphosphate; Affect; Animals; Antimanic Agents; Bipolar Disorder; Brain Chemistry; Citrat | 2015 |
Effect of valproic acid through regulation of NMDA receptor-ERK signaling in sleep deprivation rats.
Topics: Animals; Antimanic Agents; Frontal Lobe; Hippocampus; Male; MAP Kinase Signaling System; Rats; Rats, | 2012 |
Juvenile myoclonic epilepsy: diagnosis, management and outcome.
Topics: Adolescent; Adult; Alcohol Drinking; Anticonvulsants; Carbamazepine; Epilepsies, Myoclonic; Female; | 1995 |
Influence of antiepileptic drugs on sleep patterns.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil | 1991 |
[The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure].
Topics: Alcohol Drinking; Animals; Electroencephalography; Individuality; Male; Rats; Sleep; Sleep Deprivati | 1989 |
Interictal EEG prediction of response to antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr | 1985 |
Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following 1 night total sleep deprivation in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Human | 1985 |