valproic acid has been researched along with Impotence in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 7.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| "We investigated the therapeutic effects of valproic acid (VPA) on erectile dysfunction and reducing penile fibrosis in streptozocin (STZ)-induced diabetic rats." | 3.83 | Antifibrogenic role of valproic acid in streptozotocin induced diabetic rat penis. ( Bayraktar, C; Eren, H; Gurgen, SG; Karaguzel, E; Kazaz, IO; Kutlu, O; Kutlu, S; Okatan, AE, 2016) |
| "The effects of the antiepileptic drugs sodium valproate (VPA) and levetiracetam (LEV) on reproductive endocrine function, sexual function, and spermatozoa were explored, together with their possible etiological mechanisms, in Chinese Han men with epilepsy." | 3.79 | Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy. ( Daoliang, X; Hengzhong, Z; Xiaotian, X; Yao, X; Yumei, W; Zhipan, Z, 2013) |
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 3.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Watkins, LV | 1 |
| Angus-Leppan, H | 1 |
| Xiaotian, X | 1 |
| Hengzhong, Z | 1 |
| Yao, X | 1 |
| Zhipan, Z | 1 |
| Daoliang, X | 1 |
| Yumei, W | 1 |
| Hannan, JL | 1 |
| Kutlu, O | 2 |
| Stopak, BL | 1 |
| Liu, X | 1 |
| Castiglione, F | 1 |
| Hedlund, P | 1 |
| Burnett, AL | 1 |
| Bivalacqua, TJ | 1 |
| Karaguzel, E | 1 |
| Gurgen, SG | 1 |
| Okatan, AE | 1 |
| Kutlu, S | 1 |
| Bayraktar, C | 1 |
| Kazaz, IO | 1 |
| Eren, H | 1 |
| Calabrò, RS | 1 |
| Italiano, D | 1 |
| Militi, D | 1 |
| Bramanti, P | 1 |
| Szupera, Z | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| Rättyä, J | 1 |
| Turkka, J | 1 |
| Pakarinen, AJ | 1 |
| Knip, M | 1 |
| Kotila, MA | 1 |
| Lukkarinen, O | 1 |
| Myllylä, VV | 1 |
| Isojärvi, JI | 1 |
2 reviews available for valproic acid and Impotence
| Article | Year |
|---|---|
Valproate, sexual health, and men: A narrative review.
Topics: Anticonvulsants; Epilepsy; Erectile Dysfunction; Female; Humans; Male; Sexual Behavior; Sexual Dysfu | 2020 |
[The role of the antiepileptic drugs at the development of the sexual dysfunctions in male epileptic patients].
Topics: Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Erectile Dysfunction; | 2007 |
6 other studies available for valproic acid and Impotence
| Article | Year |
|---|---|
Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Erectile Dysfunction; Follicle Stimulati | 2013 |
Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.
Topics: Animals; Blotting, Western; Erectile Dysfunction; Fibrosis; Histone Deacetylase Inhibitors; Histone | 2014 |
Antifibrogenic role of valproic acid in streptozotocin induced diabetic rat penis.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Erectile Dysfunction; Humans; Injections, Intra | 2016 |
Levetiracetam-associated loss of libido and anhedonia.
Topics: Adult; Anhedonia; Anticonvulsants; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, C | 2012 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.
Topics: Adolescent; Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; | 2001 |