valproic acid has been researched along with Hypoxia in 28 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro." | 7.83 | Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia. ( Babenko, VA; Gulyaev, MV; Pevzner, IB; Pirogov, YA; Plotnikov, EY; Savchenko, ES; Silachev, DN; Sukhikh, GT; Zorov, DB; Zorova, LD, 2016) |
| "Male Sprague-Dawley rats were injected with a single, subcutaneous dose of monocrotaline (60 mg/kg), and were exposed to chronic hypoxia to induce severe PH." | 7.81 | Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension. ( Furutani, Y; Hayama, E; Kawaguchi, N; Lan, B; Nakanishi, T, 2015) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 7.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| " Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat." | 7.78 | Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012) |
| "This study tested if the antidepressant imipramine or the mood stabilizers lithium and sodium valproate regulated pathophysiological serine-dephosphorylation of GSK3 caused by hypoxia in mouse brain in vivo." | 7.73 | Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine. ( De Sarno, P; Eom, TY; Jope, RS; Roh, MS; Roth, KA; Zmijewska, AA, 2005) |
| "To examine the effect of combined method on enhancing gene expression, we compared neuronal cell-inducible luciferase levels under normoxia or hypoxia conditions in induced neural stem cells with valproic acid." | 3.96 | Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions. ( Baek, D; Cheong, E; Ha, Y; Kim, J; Lee, D; Oh, J; Yun, Y, 2020) |
| "Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro." | 3.83 | Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia. ( Babenko, VA; Gulyaev, MV; Pevzner, IB; Pirogov, YA; Plotnikov, EY; Savchenko, ES; Silachev, DN; Sukhikh, GT; Zorov, DB; Zorova, LD, 2016) |
| "Male Sprague-Dawley rats were injected with a single, subcutaneous dose of monocrotaline (60 mg/kg), and were exposed to chronic hypoxia to induce severe PH." | 3.81 | Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension. ( Furutani, Y; Hayama, E; Kawaguchi, N; Lan, B; Nakanishi, T, 2015) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 3.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| " Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat." | 3.78 | Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012) |
| "This study tested if the antidepressant imipramine or the mood stabilizers lithium and sodium valproate regulated pathophysiological serine-dephosphorylation of GSK3 caused by hypoxia in mouse brain in vivo." | 3.73 | Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine. ( De Sarno, P; Eom, TY; Jope, RS; Roh, MS; Roth, KA; Zmijewska, AA, 2005) |
| "Post-hypoxic myoclonus (PHM) is a rare neurological complication having two different variants depending on acute or chronic onset after cardiopulmonary resuscitation following cardiac arrest: myoclonic status epilepticus (MSE) and Lance-Adams syndrome (LAS) respectively." | 3.01 | Post-hypoxic myoclonus; what we know and gaps in knowledge. ( Ahmed, HS, 2023) |
| "Postanoxic myoclonus is a rare manifestation after an anoxic event, with fewer than 150 cases reported in the literature." | 1.40 | Postanoxic myoclonus: two case presentations and review of medical management. ( Budhram, A; Harvey, D; Lipson, D; Nesathurai, S; Rathbone, MP, 2014) |
| "While in the anoxia group, the concentration of Ca2+ decreased by (103+/-45)% after the addition of VPA." | 1.32 | [Changes in Ca2+ concentration mediated by N-methyl-D-aspartate receptor in PO/AH neurons of anoxic SD rats]. ( Chen, GZ; Li, TL; Zhao, QP; Zou, F, 2004) |
| "We have previously reported that chronic administration of valproate in developing mice decreased brain aspartic and glutamic acid levels and increased the brain taurine content." | 1.28 | Valproate doubles the anoxic survival time of normal developing mice: possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine. ( Hauhart, RE; Thurston, JH, 1989) |
| " Two VA-filled Alzet osmotic minipumps were implanted subcutaneously on gestation day 5 for continuous exposure of a total daily dosage of 850 mg/kg on gestation days 5-12." | 1.27 | Effects of sodium valproate and oxygen on the CD-1 mouse fetus. ( Hayes, TG; Kernan, B; Oca, M; Paulson, RB; Sachs, LA; Sucheston, ME; Weiss, HS; Weiss, S, 1988) |
| "Disappearance of the myoclonus occurred with marked improvement in the electroencephalogram." | 1.26 | Treatment of postanoxic intention myoclonus with valproic acid. ( Bruni, J; Wilder, BJ; Willmore, LJ, 1979) |
| "A patient with postanoxic action myoclonus (Lance-Adams syndrome) was severely disabled with this movement disorder." | 1.26 | Postanoxic action myoclonus (Lance-Adams syndrome) responding to valproate. ( Gilligan, BS; Rollinson, RD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Kane, JM | 1 |
| Baron, BM | 1 |
| Dudley, MW | 1 |
| Sorensen, SM | 1 |
| Staeger, MA | 1 |
| Miller, FP | 1 |
| Ahmed, HS | 1 |
| Yun, Y | 1 |
| Baek, D | 1 |
| Lee, D | 1 |
| Cheong, E | 1 |
| Kim, J | 1 |
| Oh, J | 1 |
| Ha, Y | 1 |
| Wang, W | 1 |
| Tang, J | 1 |
| Zhong, M | 1 |
| Chen, J | 1 |
| Li, T | 3 |
| Dai, Y | 1 |
| Hilly-Ginoux, J | 1 |
| Merceron, S | 1 |
| Pinoteau, J | 1 |
| Palette, C | 1 |
| Bedos, JP | 1 |
| Legriel, S | 1 |
| Budhram, A | 1 |
| Lipson, D | 1 |
| Nesathurai, S | 1 |
| Harvey, D | 1 |
| Rathbone, MP | 1 |
| Wang, Z | 2 |
| Zhang, XJ | 1 |
| Li, J | 2 |
| Tang, Y | 2 |
| Le, W | 2 |
| Lan, B | 1 |
| Hayama, E | 1 |
| Kawaguchi, N | 1 |
| Furutani, Y | 1 |
| Nakanishi, T | 1 |
| Zuckermann, AM | 1 |
| La Ragione, RM | 1 |
| Baines, DL | 1 |
| Williams, RS | 1 |
| Silachev, DN | 1 |
| Plotnikov, EY | 1 |
| Babenko, VA | 1 |
| Savchenko, ES | 1 |
| Zorova, LD | 1 |
| Pevzner, IB | 1 |
| Gulyaev, MV | 1 |
| Pirogov, YA | 1 |
| Sukhikh, GT | 1 |
| Zorov, DB | 1 |
| Yang, D | 1 |
| Zhang, X | 1 |
| Zhao, L | 1 |
| Chen, CN | 1 |
| Hajji, N | 1 |
| Oliver, E | 1 |
| Cotroneo, E | 1 |
| Wharton, J | 1 |
| Wang, D | 1 |
| Li, M | 1 |
| McKinsey, TA | 1 |
| Stenmark, KR | 1 |
| Wilkins, MR | 1 |
| Rekling, JC | 1 |
| Zhao, QP | 1 |
| Zou, F | 1 |
| Chen, GZ | 1 |
| Li, TL | 1 |
| Patel, R | 1 |
| Jha, S | 1 |
| Roh, MS | 1 |
| Eom, TY | 1 |
| Zmijewska, AA | 1 |
| De Sarno, P | 1 |
| Roth, KA | 1 |
| Jope, RS | 1 |
| Li, Y | 1 |
| Yuan, Z | 1 |
| Liu, B | 1 |
| Sailhamer, EA | 1 |
| Shults, C | 1 |
| Velmahos, GC | 1 |
| Demoya, M | 1 |
| Alam, HB | 1 |
| Larner, AJ | 1 |
| Heafield, MT | 1 |
| Bruni, J | 1 |
| Willmore, LJ | 1 |
| Wilder, BJ | 1 |
| Fahn, S | 3 |
| Nataf, N | 1 |
| Gourmel, B | 1 |
| Rossignol, P | 1 |
| Rollinson, RD | 1 |
| Gilligan, BS | 1 |
| Van Woert, MH | 1 |
| Rosenbaum, D | 1 |
| Chung, EY | 1 |
| Thurston, JH | 1 |
| Hauhart, RE | 1 |
| Meldrum, BS | 1 |
| Paulson, RB | 1 |
| Sucheston, ME | 1 |
| Hayes, TG | 1 |
| Weiss, HS | 1 |
| Sachs, LA | 1 |
| Oca, M | 1 |
| Kernan, B | 1 |
| Weiss, S | 1 |
3 reviews available for valproic acid and Hypoxia
| Article | Year |
|---|---|
Post-hypoxic myoclonus; what we know and gaps in knowledge.
Topics: Cardiopulmonary Resuscitation; Clonazepam; Humans; Hypoxia; Myoclonus; Syndrome; Valproic Acid | 2023 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
25 other studies available for valproic acid and Hypoxia
| Article | Year |
|---|---|
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Gerbillinae; Hippocampus; Hypoxia | 1990 |
Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions.
Topics: Cell Survival; Cell Transplantation; Gene Expression; Genetic Therapy; Humans; Hypoxia; Luciferases; | 2020 |
HIF-1 α may play a role in late pregnancy hypoxia-induced autism-like behaviors in offspring rats.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Hypoxia; Hypoxia-Inducible Factor | 2021 |
Intravenous valproate in twelve patients with post-anoxic status epilepticus.
Topics: Adult; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Cohort Studies; Dose-Response Relatio | 2013 |
Postanoxic myoclonus: two case presentations and review of medical management.
Topics: Aged; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Humans; Hypoxia; Levetiracetam; Male; | 2014 |
Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.
Topics: Amyloid beta-Protein Precursor; Animals; Chromatin Immunoprecipitation; Down-Regulation; Female; Hum | 2014 |
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hemodynamics; Histone Deacetylase Inhibitors; Hyper | 2015 |
Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.
Topics: Apoptosis; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hy | 2015 |
Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia.
Topics: Animals; Animals, Newborn; Brain Injuries; Hypoxia; Hypoxia-Ischemia, Brain; Lithium Chloride; Rats; | 2016 |
Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons.
Topics: Animals; Astrocytes; Cerebral Cortex; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Ex | 2011 |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Histone Deacetylase 1; Histone | 2012 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; | 2003 |
[Changes in Ca2+ concentration mediated by N-methyl-D-aspartate receptor in PO/AH neurons of anoxic SD rats].
Topics: Adenosine Triphosphate; Animals; Calcium; Female; Hypoxia; Male; Neurons; Preoptic Area; Rats; Rats, | 2004 |
Intravenous valproate in post-anoxic myoclonic status epilepticus: a report of ten patients.
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; H | 2004 |
Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Carbon Dioxide; Dose-Response Rel | 2005 |
Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Caspases; Cell Survival; Cells, Cultured; Embryo | 2008 |
Post anoxic action myoclonus.
Topics: Clonazepam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Hypoxia; Male; Middle Aged; Pi | 1993 |
Treatment of postanoxic intention myoclonus with valproic acid.
Topics: Humans; Hypoxia; Male; Middle Aged; Myoclonus; Valproic Acid | 1979 |
Posthypoxic action myoclonus: review of the literature and report of two new cases with response to valproate and estrogen.
Topics: Adult; Brain Diseases; Estrogens, Conjugated (USP); Female; Humans; Hypoxia; Hypoxia, Brain; Male; M | 1979 |
Pharmacological actions on hypoxic increase of rat brain cortex extracellular K+ ion.
Topics: Animals; Cerebral Cortex; Extracellular Space; Hypoxia; Male; Phenytoin; Potassium; Propranolol; Pyr | 1978 |
Postanoxic action myoclonus (Lance-Adams syndrome) responding to valproate.
Topics: Adult; Drowning; Female; Humans; Hypoxia; Myoclonus; Valproic Acid | 1979 |
Biochemistry and therapeutics of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electro | 1986 |
Newer drugs for posthypoxic action myoclonus: observations from a well-studied case.
Topics: Clonazepam; Drug Therapy, Combination; Estrogens, Conjugated (USP); Fasting; Female; Humans; Hydroxy | 1986 |
Valproate doubles the anoxic survival time of normal developing mice: possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine.
Topics: Animals; Animals, Suckling; Aspartic Acid; Body Weight; Brain; Glucose; Glutamates; Hypoxia; Mice; T | 1989 |
Effects of sodium valproate and oxygen on the CD-1 mouse fetus.
Topics: Animals; Female; Fetal Resorption; Fetus; Hematoma; Hypoxia; Mice; Mice, Inbred Strains; Oxygen; Pre | 1988 |