valproic acid has been researched along with Hypothermia in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This case report describes a 28-year-old male presenting status-post multiple tonic-clonic seizures, treated for persistent seizure activity refractory to benzodiazepines with valproic acid (VPA), levetiracetam, and fosphenytoin." | 7.88 | A cool side effect of valproic acid administration: Single dose-induced hypothermia. ( Priano, J; Schiel, J; Servati, N; Vilar, J, 2018) |
| "We sought to explore a possible association between the concomitant use of topiramate and valproic acid and the induction of hypothermia." | 7.74 | Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy. ( Flowers, CM; Knudsen, JF; Sokol, GH, 2008) |
| "The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine." | 7.72 | Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy. ( Chen, KC; Chen, PS; Yang, MJ; Yang, YK; Yeh, TL, 2003) |
| "Hypothermia is a rare but serious condition that has been associated with various psychiatric medications." | 5.46 | Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy. ( Ajayi, OO; Holroyd, S, 2017) |
| " This case report describes a 28-year-old male presenting status-post multiple tonic-clonic seizures, treated for persistent seizure activity refractory to benzodiazepines with valproic acid (VPA), levetiracetam, and fosphenytoin." | 3.88 | A cool side effect of valproic acid administration: Single dose-induced hypothermia. ( Priano, J; Schiel, J; Servati, N; Vilar, J, 2018) |
| "We sought to explore a possible association between the concomitant use of topiramate and valproic acid and the induction of hypothermia." | 3.74 | Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy. ( Flowers, CM; Knudsen, JF; Sokol, GH, 2008) |
| "The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine." | 3.72 | Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy. ( Chen, KC; Chen, PS; Yang, MJ; Yang, YK; Yeh, TL, 2003) |
| "Hypothermia induced by LY 300164 combined with VPA may be useful in various central nervous system disease treatments." | 3.72 | Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice? ( Czuczwar, SJ; Luszczki, JJ; Swiader, MJ; Wielosz, M; Wierzchowska-Cioch, E; Zwolan, A, 2004) |
| "We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM)." | 3.71 | Topiramate enhances the risk of valproate-associated side effects in three children. ( Koelfen, W; König, S; Longin, E; Teich, M, 2002) |
| " Bicuculline increases GABA-induced hypothermia, does not modify DAVA (250 mg/kg) and VPA (100 and 400 mg/kg) hypothermia and antagonizes initial hypothermia by DAVA (1000 mg/kg) and VPA (200 mg/kg) and late hypothermia by DAVA (500 mg/kg) and VPA (200 mg/kg)." | 3.67 | Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists. ( Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS, 1985) |
| "Hypothermia is a rare but serious condition that has been associated with various psychiatric medications." | 1.46 | Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy. ( Ajayi, OO; Holroyd, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ajayi, OO | 1 |
| Holroyd, S | 1 |
| Servati, N | 1 |
| Priano, J | 1 |
| Vilar, J | 1 |
| Schiel, J | 1 |
| Zuckermann, AM | 1 |
| La Ragione, RM | 1 |
| Baines, DL | 1 |
| Williams, RS | 1 |
| Knudsen, JF | 1 |
| Sokol, GH | 1 |
| Flowers, CM | 1 |
| Chen, KC | 1 |
| Yang, YK | 1 |
| Chen, PS | 1 |
| Yeh, TL | 1 |
| Yang, MJ | 1 |
| Swiader, MJ | 1 |
| Luszczki, JJ | 1 |
| Zwolan, A | 1 |
| Wierzchowska-Cioch, E | 1 |
| Wielosz, M | 1 |
| Czuczwar, SJ | 1 |
| Robinson, P | 1 |
| Abbott, C | 1 |
| Zachariah, SB | 1 |
| Zachariah, A | 1 |
| Ananda, R | 1 |
| Stewart, JT | 1 |
| Nagarajan, L | 1 |
| Johnston, K | 1 |
| Williams, S | 1 |
| Longin, E | 1 |
| Teich, M | 1 |
| Koelfen, W | 1 |
| König, S | 1 |
| Serrano, JS | 1 |
| Miñano, FJ | 1 |
| Sancibrián, M | 1 |
| Durán, JA | 1 |
11 other studies available for valproic acid and Hypothermia
| Article | Year |
|---|---|
Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy.
Topics: Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Drug Therapy, Combinat | 2017 |
A cool side effect of valproic acid administration: Single dose-induced hypothermia.
Topics: Adult; Anticonvulsants; Humans; Hypothermia; Levetiracetam; Male; Phenytoin; Seizures; Valproic Acid | 2018 |
Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.
Topics: Apoptosis; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hy | 2015 |
Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Algorithms; Amm | 2008 |
Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Diazepam; Diben | 2003 |
Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice?
Topics: Animals; Anticonvulsants; Benzodiazepines; Body Temperature; Drug Therapy, Combination; Female; Hypo | 2004 |
Severe hypothermia in association with sodium valproate overdose.
Topics: Adult; Drug Overdose; GABA Agents; Humans; Hypothermia; Male; Rewarming; Treatment Outcome; Valproic | 2005 |
Hypothermia and thermoregulatory derangements induced by valproic acid.
Topics: Adult; Aged; Anticonvulsants; Body Temperature Regulation; Humans; Hypothermia; Male; Middle Aged; V | 2000 |
Hypothermia and thermoregulatory derangements induced by valproic acid.
Topics: Anticonvulsants; Body Temperature Regulation; Child, Preschool; Humans; Hypothermia; Male; Seizures, | 2001 |
Topiramate enhances the risk of valproate-associated side effects in three children.
Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combinati | 2002 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female | 1985 |