valproic acid has been researched along with Hyponatremia in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reported is a 16-year-old man with intractable epilepsy and an 11-year history of chronic hyponatraemia (126-135 mEq/L) due to valproic acid induced syndrome of inappropriate antidiuresis who sustained low-impact fragility fractures and had evidence of osteopaenia on both X-ray and dual energy X-ray absorptiometry (DEXA)." | 3.91 | Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male. ( Ayus, JC; Moritz, ML; Patel, M, 2019) |
| " This study compared the effects of the antimanic drugs, lithium and valproic acid, on GABA and glutamine CSF concentration and on head-shakes during hyponatremia." | 3.70 | Dissimilar effects of lithium and valproic acid on GABA and glutamine concentrations in rat cerebrospinal fluid. ( Barros, HM; Tannhauser, M; Vargas, C, 1998) |
| "Severe hyponatremia was defined as a serum sodium level < 130 mEq/L." | 1.51 | Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study. ( Imai, K; Inoue, Y; Kagawa, Y; Ohta, A; Takahashi, Y; Yamamoto, Y, 2019) |
| " We consider this episode of SIADH to be the result of a combination of factors including a weakness of the central nervous system and the long-term administration of VPA." | 1.31 | Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone. ( Horiguchi, J; Ishino, H; Itoga, M; Kishi, T; Miyaoka, T; Seno, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, Y | 1 |
| Takahashi, Y | 1 |
| Imai, K | 1 |
| Ohta, A | 1 |
| Kagawa, Y | 1 |
| Inoue, Y | 1 |
| Unger, M | 1 |
| Xiong, G | 1 |
| Patel, M | 1 |
| Ayus, JC | 1 |
| Moritz, ML | 1 |
| Lin, MW | 1 |
| Chang, C | 1 |
| Yeh, CB | 1 |
| Tai, YM | 1 |
| Chang, HA | 1 |
| Kao, YC | 1 |
| Tzeng, NS | 1 |
| Franco Hidalgo, S | 1 |
| Prieto de Paula, JM | 1 |
| Salado Valdivieso, I | 1 |
| Beers, E | 1 |
| van Puijenbroek, EP | 1 |
| Bartelink, IH | 1 |
| van der Linden, CM | 1 |
| Jansen, PA | 1 |
| Berendes, K | 1 |
| Tsuru, T | 1 |
| Akiyama, R | 1 |
| Kohashi, K | 1 |
| Okumura, K | 1 |
| Bavbek, N | 1 |
| Alkan, R | 1 |
| Uz, E | 1 |
| Kaftan, O | 1 |
| Akcay, A | 1 |
| Vargas, C | 2 |
| Tannhauser, M | 2 |
| Tannhauser, SL | 1 |
| Barros, HM | 2 |
| Branten, AJ | 1 |
| Wetzels, JF | 1 |
| Weber, AM | 1 |
| Koene, RA | 1 |
| Miyaoka, T | 1 |
| Seno, H | 1 |
| Itoga, M | 1 |
| Kishi, T | 1 |
| Ishino, H | 1 |
| Horiguchi, J | 1 |
| Karper, LP | 1 |
| Seibyl, JP | 1 |
| Krystal, JH | 1 |
14 other studies available for valproic acid and Hyponatremia
| Article | Year |
|---|---|
Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; | 2019 |
Treatment of refractory psychogenic polydipsia with lithium.
Topics: Antipsychotic Agents; Enzyme Inhibitors; Humans; Hyponatremia; Lithium; Male; Polydipsia, Psychogeni | 2017 |
Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male.
Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Epileps | 2019 |
Aripiprazole-related hyponatremia and consequent valproic acid-related hyperammonemia in one patient.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Female; Humans; Hyper | 2017 |
[Inadequate vasopressin secretion and valproate].
Topics: Aged, 80 and over; Antimanic Agents; Bipolar Disorder; Comorbidity; Humans; Hyponatremia; Inappropri | 2009 |
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) or hyponatraemia associated with valproic Acid: four case reports from the Netherlands and a case/non-case analysis of vigibase.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anticonvulsants; Databases, Factua | 2010 |
[Hypo- and hypernatremia].
Topics: Anticonvulsants; Antimanic Agents; Carbamazepine; Diabetes Insipidus, Nephrogenic; Humans; Hypernatr | 2011 |
[Case of a 13-year-old boy with hyponatremia due to lamotrigine-induced syndrome of inappropriate secretion of antidiuretic hormone].
Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Humans; Hyponatremia; Inappropriate ADH Synd | 2012 |
Hyponatremia associated with sodium valproate in a 22-year-old male.
Topics: Adult; Anticonvulsants; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Valproic Acid | 2008 |
Lithium and valproate combined administration: acute behavioural effects and drug plasma levels.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Female; Flame I | 1996 |
Hyponatremia due to sodium valproate.
Topics: Anticonvulsants; Epilepsy; Humans; Hyponatremia; Male; Middle Aged; Valproic Acid | 1998 |
Dissimilar effects of lithium and valproic acid on GABA and glutamine concentrations in rat cerebrospinal fluid.
Topics: Animals; Antimanic Agents; Female; gamma-Aminobutyric Acid; Glutamine; Hyponatremia; Lithium Chlorid | 1998 |
Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Hyponatremia; Inappropriate ADH Syndrome; M | 2001 |
Valproate management of psychosis in a patient with carbamazepine-induced hyponatremia.
Topics: Carbamazepine; Chronic Disease; Drinking; Drug Therapy, Combination; Humans; Hyponatremia; Male; Mid | 1992 |