valproic acid has been researched along with Hypoglycemia in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 7.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "Previous studies have demonstrated that the nitric oxide (NO) synthase inhibitor L-NAME exerts positive effects on the arginine vasopressin (AVP) and oxytocin (OT) responses to insulin-induced hypoglycemia, suggesting inhibitory actions of NO." | 7.69 | Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia. ( Capretti, L; Chiodera, P; Coiro, V; Volpi, R, 1996) |
| "The present study was performed in order to establish whether angiotensin II (ANG II) and/or insulin-induced hypoglycemia exert their oxytocin (OT)-releasing effects by interacting with a GABAergic pathway." | 7.68 | Different effects of the GABAergic agent sodium valproate on the oxytocin responses to angiotensin II and insulin-induced hypoglycemia in normal men. ( Chiodera, P; Coiro, V, 1991) |
| "The present study was carried out in order to determine whether insulin-induced hypoglycemia exerts its stimulatory effect on plasma concentrations of arginine vasopressin (AVP) by interacting with a serotonergic, a GABA-ergic or an opioid pathway." | 7.67 | Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man. ( Bianconi, L; Castelli, A; Chiodera, P; d'Amato, L; Gnudi, A; Marchesi, C; Minelli, R; Muzzetto, P; Pioli, G; Volpi, R, 1988) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 3.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine." | 3.70 | Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000) |
| "Previous studies have demonstrated that the nitric oxide (NO) synthase inhibitor L-NAME exerts positive effects on the arginine vasopressin (AVP) and oxytocin (OT) responses to insulin-induced hypoglycemia, suggesting inhibitory actions of NO." | 3.69 | Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia. ( Capretti, L; Chiodera, P; Coiro, V; Volpi, R, 1996) |
| "The present study was performed in order to establish whether angiotensin II (ANG II) and/or insulin-induced hypoglycemia exert their oxytocin (OT)-releasing effects by interacting with a GABAergic pathway." | 3.68 | Different effects of the GABAergic agent sodium valproate on the oxytocin responses to angiotensin II and insulin-induced hypoglycemia in normal men. ( Chiodera, P; Coiro, V, 1991) |
| "The present study was carried out in order to determine whether insulin-induced hypoglycemia exerts its stimulatory effect on plasma concentrations of arginine vasopressin (AVP) by interacting with a serotonergic, a GABA-ergic or an opioid pathway." | 3.67 | Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man. ( Bianconi, L; Castelli, A; Chiodera, P; d'Amato, L; Gnudi, A; Marchesi, C; Minelli, R; Muzzetto, P; Pioli, G; Volpi, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Çoban, D | 1 |
| Kurtoğlu, S | 1 |
| Akın, MA | 1 |
| Akçakuş, M | 1 |
| Güneş, T | 1 |
| Chiodera, P | 3 |
| Volpi, R | 2 |
| Capretti, L | 1 |
| Coiro, V | 2 |
| Ebbesen, F | 1 |
| Joergensen, A | 1 |
| Hoseth, E | 1 |
| Kaad, PH | 1 |
| Moeller, M | 1 |
| Holsteen, V | 1 |
| Rix, M | 1 |
| Bruel, H | 1 |
| Chabrolle, JP | 1 |
| Amusini, P | 1 |
| Levesque, L | 1 |
| Iskandar, K | 1 |
| Poinsot, J | 1 |
| Gnudi, A | 1 |
| d'Amato, L | 1 |
| Marchesi, C | 1 |
| Pioli, G | 1 |
| Muzzetto, P | 1 |
| Castelli, A | 1 |
| Bianconi, L | 1 |
| Minelli, R | 1 |
| Petraglia, F | 1 |
| Bakalakis, S | 1 |
| Facchinetti, F | 1 |
| Volpe, A | 1 |
| Muller, EE | 1 |
| Genazzani, AR | 1 |
1 trial available for valproic acid and Hypoglycemia
| Article | Year |
|---|---|
Effects of sodium valproate and diazepam on beta-endorphin, beta-lipotropin and cortisol secretion induced by hypoglycemic stress in humans.
Topics: Adult; beta-Endorphin; beta-Lipotropin; Diazepam; Endorphins; Female; Humans; Hydrocortisone; Hypogl | 1986 |
6 other studies available for valproic acid and Hypoglycemia
| Article | Year |
|---|---|
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.
Topics: Anticonvulsants; Epilepsy; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, | 2010 |
Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia.
Topics: Adult; Arginine Vasopressin; Blood Glucose; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; | 1996 |
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I | 2000 |
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate].
Topics: Adult; Ammonia; Anticonvulsants; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 2001 |
Different effects of the GABAergic agent sodium valproate on the oxytocin responses to angiotensin II and insulin-induced hypoglycemia in normal men.
Topics: Adult; Angiotensin II; Blood Glucose; Humans; Hypoglycemia; Insulin; Male; Oxytocin; Valproic Acid | 1991 |
Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man.
Topics: Adrenocorticotropic Hormone; Adult; Arginine Vasopressin; Ergolines; gamma-Aminobutyric Acid; Growth | 1988 |