valproic acid has been researched along with Hypoalbuminemia in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with hypoalbuminemia after craniotomy, total serum concentrations of valproic acid (VPA) may provide poor clinical insights, owing to saturated protein binding and increased unbound fractions." | 7.96 | Prediction of Serum-Free and Cerebrospinal Fluid Valproic Acid Levels in Patients With Hypoalbuminemia After Craniotomy. ( Chen, W; Gao, W; Li, Z; Liu, G, 2020) |
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 7.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder." | 3.88 | [Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction]. ( Dols, A; Jacobs, GE; Nauta, KJ; Ruiter-Visser, R; Smulders, YM, 2018) |
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 3.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "The patient's hypoalbuminemia probably explains the remarkably high free fraction of valproic acid." | 3.77 | High unbound fraction of valproic acid in a hypoalbuminemic critically ill patient on renal replacement therapy. ( de Maat, MM; Edelbroek, PM; van Leeuwen, HJ, 2011) |
| "In patients with hypoalbuminemia, the total serum concentration of valproic acid may offer poor clinical information; however, very few clinical laboratories routinely analyze the free concentration of the drug." | 3.73 | A theoretical method for normalizing total serum valproic acid concentration in hypoalbuminemic patients. ( Hermida, J; Tutor, JC, 2005) |
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| "Hypoalbuminemia was identified as a predictor of therapeutic discordance." | 2.82 | Clinical Pharmacokinetic Monitoring of Free Valproic Acid Levels: A Systematic Review. ( Au, C; Cao, VFS; Dahri, K; Lin, K, 2022) |
| "Phenytoin has a narrow therapeutic index and the potential of under-treatment or toxicity." | 1.56 | A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients. ( Barra, ME; Chung, DY; Phillips, KM; Rosenthal, ES, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, K | 1 |
| Cao, VFS | 1 |
| Au, C | 1 |
| Dahri, K | 1 |
| Barra, ME | 1 |
| Phillips, KM | 1 |
| Chung, DY | 1 |
| Rosenthal, ES | 1 |
| Li, Z | 1 |
| Gao, W | 1 |
| Liu, G | 1 |
| Chen, W | 1 |
| Madan, A | 1 |
| Donovan, PJ | 1 |
| Risetto, T | 1 |
| Trenerry, H | 1 |
| Lander, CM | 1 |
| Doré, M | 1 |
| San Juan, AE | 1 |
| Frenette, AJ | 1 |
| Williamson, D | 1 |
| Dautzenberg, G | 1 |
| Nederlof, M | 1 |
| Beekman, A | 1 |
| Egberts, T | 1 |
| Heerdink, ER | 1 |
| Ruiter-Visser, R | 1 |
| Dols, A | 1 |
| Smulders, YM | 1 |
| Jacobs, GE | 1 |
| Nauta, KJ | 1 |
| Drisaldi, A | 1 |
| Weeda, E | 1 |
| Neyens, R | 1 |
| Orvin, N | 1 |
| Bonilha, L | 1 |
| Campbell, Z | 1 |
| Bohm, N | 1 |
| Suzuki, K | 1 |
| Hiramoto, A | 1 |
| Okumura, T | 1 |
| de Maat, MM | 1 |
| van Leeuwen, HJ | 1 |
| Edelbroek, PM | 1 |
| Jansen, AJ | 1 |
| Hunfeld, NG | 1 |
| van Bommel, J | 1 |
| Koch, BC | 1 |
| van Gelder, T | 1 |
| Rugino, TA | 1 |
| Janvier, YM | 1 |
| Baunach, JM | 1 |
| Bilat, CA | 1 |
| Lagneau, F | 1 |
| Perbet, S | 1 |
| Delefosse, D | 1 |
| Wernet, A | 1 |
| Stocco, J | 1 |
| Marty, J | 1 |
| Hermida, J | 1 |
| Tutor, JC | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Valproic Acid-associated Hypoalbuminemia in Medically Fragile Pediatric and Young Adult Patients in a Long Term Care Facility Part 1: Potential Mechanism for Decreased Albumin Synthesis[NCT00723762] | 90 participants (Anticipated) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Hypoalbuminemia
| Article | Year |
|---|---|
Clinical Pharmacokinetic Monitoring of Free Valproic Acid Levels: A Systematic Review.
Topics: Anticonvulsants; Drug Monitoring; Humans; Hypoalbuminemia; Protein Binding; Valproic Acid | 2022 |
14 other studies available for valproic acid and Hypoalbuminemia
| Article | Year |
|---|---|
A Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Critical Care; Critical Illness; Drug Monitoring; F | 2020 |
Prediction of Serum-Free and Cerebrospinal Fluid Valproic Acid Levels in Patients With Hypoalbuminemia After Craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cerebrospinal Fluid; Craniotomy; Drug Monitoring; Female | 2020 |
Monitoring for valproate and phenytoin toxicity in hypoalbuminaemia: A retrospective cohort study.
Topics: Cohort Studies; Humans; Hypoalbuminemia; Phenytoin; Retrospective Studies; Valproic Acid | 2021 |
Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Hypoalbu | 2017 |
Severe Cognitive Impairment Associated With a High Free But Therapeutic Total Concentration of Valproic Acid Due to Hypoalbuminemia in an Older Patient With Bipolar Disorder.
Topics: Aged; Antimanic Agents; Bipolar Disorder; Cognitive Dysfunction; Female; Humans; Hypoalbuminemia; Pr | 2018 |
[Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction].
Topics: Aged; Anticonvulsants; Bipolar Disorder; Humans; Hypoalbuminemia; Male; Mobility Limitation; Muscle | 2018 |
Accuracy of Valproic Acid Concentration Correction Based on Serum Albumin.
Topics: Adult; Aged; Central Nervous System Agents; Female; Humans; Hypoalbuminemia; Male; Middle Aged; Neur | 2019 |
A case report on reversible Pelger-Huët anomaly depending on serum free fraction of valproic acid.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Humans; Hypoalbuminemia; Lennox Gastaut Syndrome; | 2015 |
High unbound fraction of valproic acid in a hypoalbuminemic critically ill patient on renal replacement therapy.
Topics: Anticonvulsants; Critical Illness; Female; Humans; Hypoalbuminemia; Middle Aged; Renal Replacement T | 2011 |
Therapeutic drug monitoring of free fraction valproic acid in patients with hypoalbuminaemia.
Topics: Anticonvulsants; Epilepsy; Fatal Outcome; Humans; Hypoalbuminemia; Male; Middle Aged; Valproic Acid | 2012 |
Hypoalbuminemia with valproic acid administration.
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hypoalbuminemia; Male; Seizures; Se | 2003 |
Drugs pharmacokinetics in ICU patients: consequences of hypoalbuminemia upon drugs monitoring and dosing scheme.
Topics: Adult; Anticonvulsants; Humans; Hypoalbuminemia; Valproic Acid | 2004 |
A theoretical method for normalizing total serum valproic acid concentration in hypoalbuminemic patients.
Topics: Adult; Blood Chemical Analysis; Humans; Hypoalbuminemia; Middle Aged; Protein Binding; Reference Val | 2005 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |