valproic acid has been researched along with Hypertrophy, Right Ventricular in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypertrophy, Right Ventricular: Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male Sprague-Dawley rats were injected with a single, subcutaneous dose of monocrotaline (60 mg/kg), and were exposed to chronic hypoxia to induce severe PH." | 7.81 | Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension. ( Furutani, Y; Hayama, E; Kawaguchi, N; Lan, B; Nakanishi, T, 2015) |
| "Male Sprague-Dawley rats were injected with a single, subcutaneous dose of monocrotaline (60 mg/kg), and were exposed to chronic hypoxia to induce severe PH." | 3.81 | Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension. ( Furutani, Y; Hayama, E; Kawaguchi, N; Lan, B; Nakanishi, T, 2015) |
| "Although right ventricular hypertrophy (RVH) is an adaptive process to stresses such as outflow tract obstruction, uncorrected persistent RVH often results in failure of the right ventricle or even the left ventricle." | 1.36 | Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats. ( Cho, YK; Choi, WY; Eom, GH; Kee, HJ; Kim, HS; Kook, H; Ma, JS; Nam, KI, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lan, B | 1 |
| Hayama, E | 1 |
| Kawaguchi, N | 1 |
| Furutani, Y | 1 |
| Nakanishi, T | 1 |
| Cho, YK | 1 |
| Eom, GH | 1 |
| Kee, HJ | 1 |
| Kim, HS | 1 |
| Choi, WY | 1 |
| Nam, KI | 1 |
| Ma, JS | 1 |
| Kook, H | 1 |
| Bogaard, HJ | 1 |
| Mizuno, S | 1 |
| Hussaini, AA | 1 |
| Toldo, S | 1 |
| Abbate, A | 1 |
| Kraskauskas, D | 1 |
| Kasper, M | 1 |
| Natarajan, R | 1 |
| Voelkel, NF | 1 |
3 other studies available for valproic acid and Hypertrophy, Right Ventricular
| Article | Year |
|---|---|
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hemodynamics; Histone Deacetylase Inhibitors; Hyper | 2015 |
Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Histone Deacet | 2010 |
Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats.
Topics: Angiopoietin-1; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dose-Response R | 2011 |