valproic acid has been researched along with Hypertension in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats." | 7.85 | Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. ( Boini, KM; Li, N; Li, PL; Wang, W; Wang, Z; Yi, F; Zhu, Q, 2017) |
| "VPA prevented HFD-induced hypertension by downregulating angiotensin II and its receptor via inhibition of HDAC1, offering a novel therapeutic option for HFD-induced hypertension." | 7.85 | Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. ( Choi, J; Kim, JI; Kwon, TK; Park, KM; Park, S; Sohn, SI, 2017) |
| "Elevated circulating uric acid has been postulated to play an important pathophysiological role in estrogen-progestin combined oral contraceptive (COC)-induced hypertension and endothelial dysfunction." | 3.88 | Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin. ( Areola, ED; Badmus, OO; Kim, I; Michael, OS; Olatunji, LA; Omolekulo, TE, 2018) |
| " This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats." | 3.85 | Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. ( Boini, KM; Li, N; Li, PL; Wang, W; Wang, Z; Yi, F; Zhu, Q, 2017) |
| "VPA prevented HFD-induced hypertension by downregulating angiotensin II and its receptor via inhibition of HDAC1, offering a novel therapeutic option for HFD-induced hypertension." | 3.85 | Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. ( Choi, J; Kim, JI; Kwon, TK; Park, KM; Park, S; Sohn, SI, 2017) |
| " We included patients who had a diagnosis of bipolar disorder and were prescribed lithium (n = 2148), valproate (n = 1670), olanzapine (n = 1477), or quetiapine (n = 1376) as maintenance mood stabilizer treatment." | 3.83 | Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort Study. ( Geddes, JR; Hayes, JF; King, M; Marston, L; Osborn, DP; Walters, K, 2016) |
| "The present study was aimed to investigate the antihyperlipidemic and renoprotective potential of valproic acid against N(ω)-nitro-L arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats." | 3.80 | Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats. ( Dhanalakshmi, T; Manivannan, J; Raja, B; Rajeshwari, T; Silambarasan, T, 2014) |
| " The aim of the current study was to evaluate the effects of losartan (2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methyl]imidazole) and telmisartan (49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]-19-yl)methyl]-[1,19-biphenyl]-2-carboxylic acid), the angiotensin AT1 receptor antagonists which are widely used in clinical practice, on the protective action of conventional antiepileptic drugs (carbamazepine, phenytoin, valproate and phenobarbital) against maximal electroshock-induced seizures in mice." | 3.76 | Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock. ( Czuczwar, SJ; Jakubus, T; Janowska, A; Tochman-Gawda, A; Łukawski, K, 2010) |
| " Another set of rats were treated with hydralazine (25 mg/kg per day orally) to determine the pressure-independent effects of HDAC inhibition on hypertension." | 3.76 | HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. ( Cardinale, JP; Elks, CM; Francis, J; Guggilam, A; Mariappan, N; Pariaut, R; Sriramula, S, 2010) |
| "To determine whether chronic central gamma-aminobutyric acid (GABA) stimulation would attenuate development of hypertension, tail-cuff systolic pressures were measured in male spontaneously hypertensive rats (SHR) treated with either an inhibitor of GABA breakdown (valproate, VPA), or a GABA-receptor agonist (muscimol)." | 3.68 | Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. ( Hayashi, J; Kawasaki, S; Nakagawa, M; Nakata, T; Oguro, M; Sasaki, S; Takeda, K, 1990) |
| " Intraperitoneal injection of valproic acid (50-100 mg/Kg/die) for 6 weeks significantly reduced the development of DOCA-salt hypertension in rats." | 3.67 | Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats. ( Caputi, AP; Costa, G; Di Giorgio, RM; Magrì, V; Quattrone, G; Squadrito, F; Trimarchi, GR, 1984) |
| "The causes of hypertension are complex and involve both genetic and environmental factors." | 1.56 | The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. ( Byrne, CJ; Khaper, N; Khurana, S; Lamothe, J; Mercier, S; Tai, TC; Tharmalingam, S; Williamson, C, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Lamothe, J | 1 |
| Khurana, S | 1 |
| Tharmalingam, S | 1 |
| Williamson, C | 1 |
| Byrne, CJ | 1 |
| Khaper, N | 1 |
| Mercier, S | 1 |
| Tai, TC | 1 |
| Wang, Z | 1 |
| Zhu, Q | 1 |
| Wang, W | 1 |
| Yi, F | 1 |
| Li, PL | 1 |
| Boini, KM | 1 |
| Li, N | 1 |
| Choi, J | 1 |
| Park, S | 2 |
| Kwon, TK | 1 |
| Sohn, SI | 1 |
| Park, KM | 2 |
| Kim, JI | 1 |
| Omolekulo, TE | 1 |
| Areola, ED | 1 |
| Badmus, OO | 1 |
| Michael, OS | 1 |
| Kim, I | 1 |
| Olatunji, LA | 1 |
| Kee, HJ | 1 |
| Bae, EH | 1 |
| Lee, KE | 1 |
| Suh, SH | 1 |
| Kim, SW | 1 |
| Jeong, MH | 1 |
| Rajeshwari, T | 1 |
| Raja, B | 1 |
| Manivannan, J | 1 |
| Silambarasan, T | 1 |
| Dhanalakshmi, T | 1 |
| Seok, YM | 1 |
| Lee, HA | 1 |
| Hwangbo, MH | 1 |
| Kim, IK | 1 |
| Hayes, JF | 1 |
| Marston, L | 1 |
| Walters, K | 1 |
| Geddes, JR | 1 |
| King, M | 1 |
| Osborn, DP | 1 |
| Baumann, M | 1 |
| Janssen, BJ | 1 |
| Rob Hermans, JJ | 1 |
| Bartholome, R | 1 |
| Smits, JF | 1 |
| Struijker Boudier, HA | 1 |
| Verrotti, A | 1 |
| Manco, R | 1 |
| Agostinelli, S | 1 |
| Coppola, G | 1 |
| Chiarelli, F | 1 |
| Łukawski, K | 1 |
| Janowska, A | 1 |
| Jakubus, T | 1 |
| Tochman-Gawda, A | 1 |
| Czuczwar, SJ | 1 |
| Cardinale, JP | 1 |
| Sriramula, S | 1 |
| Pariaut, R | 1 |
| Guggilam, A | 1 |
| Mariappan, N | 1 |
| Elks, CM | 1 |
| Francis, J | 1 |
| Arnold, G | 1 |
| Schuh-Hofer, S | 1 |
| Magrì, V | 1 |
| Trimarchi, GR | 1 |
| Quattrone, G | 1 |
| Squadrito, F | 1 |
| Di Giorgio, RM | 1 |
| Costa, G | 1 |
| Caputi, AP | 2 |
| Rotiroti, D | 1 |
| Palella, B | 1 |
| Losi, E | 1 |
| Nistico, G | 1 |
| Meerson, FZ | 1 |
| Gimrikh, EO | 1 |
| Gutsol, LIa | 1 |
| Popov, SV | 1 |
| Plekhanov, IG | 1 |
| Sasaki, S | 1 |
| Nakata, T | 1 |
| Kawasaki, S | 1 |
| Hayashi, J | 1 |
| Oguro, M | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Feely, M | 1 |
| Cooke, J | 1 |
| Price, D | 1 |
| Singleton, S | 1 |
| Mehta, A | 1 |
| Bradford, L | 1 |
| Calvert, R | 1 |
| Lefkowitz, D | 1 |
| Harpold, G | 1 |
1 review available for valproic acid and Hypertension
| Article | Year |
|---|---|
[Comorbidities in migraine patients].
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Anxiety Disorders; Carotid Artery, | 2007 |
18 other studies available for valproic acid and Hypertension
| Article | Year |
|---|---|
The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids.
Topics: Animals; Blood Pressure; Decitabine; Dexamethasone; DNA (Cytosine-5-)-Methyltransferases; Epigenesis | 2020 |
Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats.
Topics: AC133 Antigen; Animals; Antihypertensive Agents; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hype | 2017 |
Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis.
Topics: Angiotensin II; Animals; Blotting, Western; Diet, High-Fat; Disease Models, Animal; Histone Deacetyl | 2017 |
Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aldosterone; Animals; Contraceptives, Oral, Com | 2018 |
HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity.
Topics: Animals; Cardiomegaly; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Activation; Fibr | 2013 |
Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats.
Topics: Animals; Antihypertensive Agents; Catalase; Glutathione; Glutathione Peroxidase; Hypertension; Hypol | 2014 |
Lysine deacetylase inhibition attenuates hypertension and is accompanied by acetylation of mineralocorticoid receptor instead of histone acetylation in spontaneously hypertensive rats.
Topics: Acetylation; Age Factors; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; | 2016 |
Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort Study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Cardiovascular Diseases; Chemical an | 2016 |
Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure | 2009 |
The metabolic syndrome in overweight epileptic patients treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Cardiovascular Diseases; Child; Comorbidity; Dyslipide | 2010 |
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Behavior, Animal; Benzimidazoles; | 2010 |
HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Echocardiography; Histone Deacetylas | 2010 |
Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood Pressure; Brain; Desoxycorticosterone; Ethanolamines; g | 1984 |
Evidence that a GABAergic mechanism influences the development of DOCA-salt hypertension in the rat.
Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; gamma-Aminobutyric Acid; Hypertension; M | 1982 |
[The anti-arrhythmic efficacy of sodium valproate].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Evaluation; Electrocar | 1992 |
Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats.
Topics: Animals; Blood Pressure; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Hy | 1990 |
Low-dose phenobarbitone as an indicator of compliance with drug therapy.
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Male; Middle Aged; Patient Compl | 1987 |
Treatment of ocular myoclonus with valproic acid.
Topics: Cerebral Hemorrhage; Eye Movements; Humans; Hypertension; Male; Middle Aged; Myoclonus; Oculomotor M | 1985 |