valproic acid has been researched along with Hyperprolactinemia in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hyperprolactinemia: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen patients with prolactinomas, 8 patients with non-tumoral hyperprolactinemia and 10 healthy subjects were studied: in non consecutive days, all subjects received placebo and SV at the dose of 400 and 800 mg po." | 2.68 | Different sensitivity to sodium valproate in healthy, non-tumoral and tumoral hyperprolactinemic subjects. ( Colao, A; Di Sarno, A; Di Somma, C; Ferone, D; Landi, ML; Lombardi, G; Merola, B; Sarnacchiaro, F; Tolino, A, 1997) |
| "Women with untreated epilepsy are more likely to have irregular menstrual cycles than are nonepileptic controls, indicating that the disease itself plays a role in the etiology of these reproductive abnormalities." | 2.44 | Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents. ( Hayes, FJ; Joffe, H, 2008) |
| " Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications." | 2.43 | Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. ( Carlson, HE; Correll, CU, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joffe, H | 1 |
| Hayes, FJ | 1 |
| Mendhekar, DN | 1 |
| Correll, CU | 1 |
| Carlson, HE | 1 |
| Otsuka, K | 1 |
| Sakai, A | 1 |
| Okudera, T | 1 |
| Shibata, E | 1 |
| Matoh, K | 1 |
| Kawamura, S | 1 |
| Lorenz, RA | 1 |
| Weinstein, B | 1 |
| Sarnacchiaro, F | 1 |
| Colao, A | 1 |
| Merola, B | 1 |
| Di Sarno, A | 1 |
| Landi, ML | 1 |
| Di Somma, C | 1 |
| Ferone, D | 1 |
| Tolino, A | 1 |
| Lombardi, G | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Melis, GB | 1 |
| Mais, V | 1 |
| Paoletti, AM | 1 |
| Antinori, D | 1 |
| de Ruggiero, A | 1 |
| Fioretti, P | 1 |
4 reviews available for valproic acid and Hyperprolactinemia
| Article | Year |
|---|---|
Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
Topics: Adolescent; Amenorrhea; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Bone and Bones; Epi | 2008 |
Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Child; Dibenzothiazepines; Drug Administration Schedule; Endocrine | 2006 |
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
GABAergic control of anterior pituitary function in humans.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Diazepam; Female; gamma-Aminobutyric A | 1986 |
1 trial available for valproic acid and Hyperprolactinemia
| Article | Year |
|---|---|
Different sensitivity to sodium valproate in healthy, non-tumoral and tumoral hyperprolactinemic subjects.
Topics: Adolescent; Adult; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Hyperprolactinemia; Kinetic | 1997 |
3 other studies available for valproic acid and Hyperprolactinemia
| Article | Year |
|---|---|
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child.
Topics: Age Factors; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comor | 2005 |
Oral contraceptive administration prevents relapse of periodic psychosis with hyperprolactinemia.
Topics: Adult; Antimanic Agents; Contraceptives, Oral, Hormonal; Female; Humans; Hyperprolactinemia; Menstru | 2007 |
Resolution of haloperidol-induced hyperprolactinemia with aripiprazole.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Clonazepam; Dose-Resp | 2007 |