valproic acid has been researched along with Hyperhomocysteinemia in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hyperhomocysteinemia: Condition in which the plasma levels of homocysteine and related metabolites are elevated (
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)." | 9.16 | The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012) |
| "Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)." | 5.16 | The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012) |
| " Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L." | 3.74 | Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008) |
| " A total of 25 children with idiopathic epilepsy (8 valproate, 11 carbamazepine, and 6 oxcarbazepine) and 10 healthy children were included in the study." | 3.74 | Homocysteine levels in epileptic children receiving antiepileptic drugs. ( Kurul, S; Unalp, A; Yiş, U, 2007) |
| "Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs." | 3.70 | Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000) |
| "Hyperhomocysteinemia is found to be closely associated with an enhanced risk of cerebral venous thrombosis." | 1.51 | An uncommon presentation of hyperhomocysteinemia and vitamin B ( D'Cruz, S; Kapur, V; Kaur, R, 2019) |
| " In patients with heterozygote (MTHFR) 677C/T polymorphism and under long-term use of certain drugs the determination of Hcy plasma levels may be useful to prevent the development of atherothrombotic disease." | 1.35 | Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism. ( Varoglu, AO, 2009) |
| "Valproic acid treatment, although also associated with hyperhomocysteinaemia, only shows a lowering effect on vitamin B6 levels, which seems to be independent of the MTHFR genotype." | 1.31 | Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene. ( Artuch, R; Cardo, E; Colomé, C; Farré, C; Monrós, E; Pineda, M; Valls, C; Vilaseca, MA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kapur, V | 1 |
| D'Cruz, S | 1 |
| Kaur, R | 1 |
| Apeland, T | 2 |
| Frøyland, ES | 1 |
| Kristensen, O | 2 |
| Strandjord, RE | 2 |
| Mansoor, MA | 2 |
| Belcastro, V | 1 |
| Striano, P | 1 |
| Varoglu, AO | 1 |
| McAlpine, CS | 1 |
| Bowes, AJ | 1 |
| Khan, MI | 1 |
| Shi, Y | 1 |
| Werstuck, GH | 1 |
| Bochyńska, A | 1 |
| Lipczyńska-Łojkowska, W | 1 |
| Gugała-Iwaniuk, M | 1 |
| Lechowicz, W | 1 |
| Restel, M | 1 |
| Graban, A | 1 |
| Lipska, B | 1 |
| Ryglewicz, D | 1 |
| Kurul, S | 1 |
| Unalp, A | 1 |
| Yiş, U | 1 |
| Vurucu, S | 1 |
| Demirkaya, E | 1 |
| Kul, M | 1 |
| Unay, B | 1 |
| Gul, D | 1 |
| Akin, R | 1 |
| Gokçay, E | 1 |
| Vilaseca, MA | 1 |
| Monrós, E | 1 |
| Artuch, R | 1 |
| Colomé, C | 1 |
| Farré, C | 1 |
| Valls, C | 1 |
| Cardo, E | 1 |
| Pineda, M | 1 |
1 trial available for valproic acid and Hyperhomocysteinemia
| Article | Year |
|---|---|
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Foli | 2012 |
9 other studies available for valproic acid and Hyperhomocysteinemia
| Article | Year |
|---|---|
An uncommon presentation of hyperhomocysteinemia and vitamin B
Topics: Adult; Anticoagulants; Anticonvulsants; Brain; Diuretics, Osmotic; Glycerol; Heparin; Humans; Hyperh | 2019 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; | 2008 |
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".
Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homo | 2009 |
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Brain; Brain Ischemia; Epilepsy; Humans; Hyperhomo | 2009 |
Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Endoplas | 2012 |
Homocysteine levels in epileptic children receiving antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Human | 2007 |
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressu | 2008 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E | 2000 |
Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Folic Acid; Genotype; Homocyste | 2000 |