valproic acid has been researched along with Hyperglycemia in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing." | 7.80 | The effect of hyperglycemia on the pharmacokinetics of valproic acid studied by high-performance liquid chromatography with electrochemical detection. ( Hakamata, H; Ishii, N; Kotani, A; Kotani, T; Kusu, F, 2014) |
| "The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing." | 3.80 | The effect of hyperglycemia on the pharmacokinetics of valproic acid studied by high-performance liquid chromatography with electrochemical detection. ( Hakamata, H; Ishii, N; Kotani, A; Kotani, T; Kusu, F, 2014) |
| " Here we examine the temporal relation between the onset of hyperglycemia, glucosamine accumulation in the vessel wall, ER stress, and the development of atherosclerosis." | 3.75 | Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model. ( Bowes, AJ; Khan, MI; Pichna, BA; Shi, Y; Werstuck, GH, 2009) |
| "Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues." | 1.48 | Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors. ( Bhadada, S; Dudhrejiya, A; Patel, B; Rabadiya, S; Vaishnav, D, 2018) |
| "Hyperglycemia was induced by streptozotocin (STZ) injection 3 days before." | 1.42 | Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion. ( Abe, A; Aoki, J; Kimura, K; Nishiyama, Y; Nito, C; Okubo, S; Sakamoto, Y; Suda, S; Suzuki, K; Ueda, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Felisbino, MB | 1 |
| Ziemann, M | 1 |
| Khurana, I | 1 |
| Okabe, J | 1 |
| Al-Hasani, K | 1 |
| Maxwell, S | 1 |
| Harikrishnan, KN | 1 |
| de Oliveira, CBM | 1 |
| Mello, MLS | 1 |
| El-Osta, A | 1 |
| Rabadiya, S | 1 |
| Bhadada, S | 1 |
| Dudhrejiya, A | 1 |
| Vaishnav, D | 1 |
| Patel, B | 1 |
| Kotani, A | 1 |
| Kotani, T | 1 |
| Ishii, N | 1 |
| Hakamata, H | 1 |
| Kusu, F | 1 |
| Suda, S | 1 |
| Ueda, M | 1 |
| Nito, C | 1 |
| Nishiyama, Y | 1 |
| Okubo, S | 1 |
| Abe, A | 1 |
| Aoki, J | 1 |
| Suzuki, K | 1 |
| Sakamoto, Y | 1 |
| Kimura, K | 1 |
| Bowes, AJ | 3 |
| Khan, MI | 3 |
| Shi, Y | 3 |
| Robertson, L | 1 |
| Werstuck, GH | 3 |
| Chang, HH | 1 |
| Chou, CH | 1 |
| Chen, PS | 1 |
| Gean, PW | 1 |
| Huang, HC | 1 |
| Lin, CY | 1 |
| Yang, YK | 1 |
| Lu, RB | 1 |
| Pichna, BA | 1 |
| Hansen, N | 1 |
| Beck, M | 1 |
| Leykamm, S | 1 |
| Kleinschnitz, C | 1 |
| McAlpine, CS | 1 |
| Kouyoumdjian, JA | 1 |
1 review available for valproic acid and Hyperglycemia
| Article | Year |
|---|---|
[Arm and blood glucose out of control].
Topics: Aged; Brain; Diabetes Mellitus, Type 2; Diagnosis, Differential; Dyskinesias; GABA Agents; Humans; H | 2009 |
1 trial available for valproic acid and Hyperglycemia
| Article | Year |
|---|---|
[Hemiballism treated with valproic acid: report of 2 cases].
Topics: Aged; Clinical Trials as Topic; Female; Humans; Hyperglycemia; Male; Middle Aged; Movement Disorders | 1984 |
8 other studies available for valproic acid and Hyperglycemia
| Article | Year |
|---|---|
Valproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways.
Topics: Blood Coagulation; Complement System Proteins; Gene Expression Regulation; Hep G2 Cells; Hepatocytes | 2021 |
Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors.
Topics: Animals; Cardiomegaly; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Cardiomy | 2018 |
The effect of hyperglycemia on the pharmacokinetics of valproic acid studied by high-performance liquid chromatography with electrochemical detection.
Topics: Administration, Oral; Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitu | 2014 |
Valproic acid ameliorates ischemic brain injury in hyperglycemic rats with permanent middle cerebral occlusion.
Topics: Animals; Blood Glucose; Brain; Brain Ischemia; Hyperglycemia; Infarction, Middle Cerebral Artery; Ma | 2015 |
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Blotting, Western; Cells, Cultured; Endoplasmic Reticul | 2009 |
High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan.
Topics: Adult; Analysis of Variance; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Blood Glucose | 2009 |
Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endoplasmic Re | 2009 |
Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Endoplas | 2012 |