valproic acid has been researched along with Hyperandrogenism in 33 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 9.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 7.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| "Treatment with metformin or rosiglitazone prevents excess adrenal androgen synthesis." | 5.34 | Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone. ( Bahtiyar, G; Sacerdote, AS; Weiss, K, 2007) |
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 5.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| " Therefore, this multicenter cross-sectional study aimed to evaluate the prevalence of reproductive endocrine dysfunctions in pubertal females with epilepsy receiving VPA, lamotrigine (LTG), or levetiracetam (LEV) monotherapy." | 3.80 | Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen? ( Agostinelli, S; Baumann, M; Haberlandt, E; Luef, G; Pizzolorusso, A; Prieschl, M; Rauchenzauner, M; Roscia, S; Rostasy, K; Verrotti, A; Wildt, L, 2014) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 3.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| " Anthropometric measurements, staging of pubertal maturation, and clinical manifestations of hyperandrogenism were assessed, as well as measurement of serum levels of testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI)." | 3.72 | Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. ( Abd El-Basset, FZ; El Barbary, NS; El-Khayat, HA; Hakky, SM; Mohamed, MS; Nassef, NM; Tohamy, SM; Tomoum, HY; Zaky, AA, 2004) |
| "Treatment with metformin or rosiglitazone prevents excess adrenal androgen synthesis." | 1.34 | Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone. ( Bahtiyar, G; Sacerdote, AS; Weiss, K, 2007) |
| "Hyperandrogenism was not found in valproate-treated boys." | 1.32 | [Effects of valproate on sexual development]. ( Andrés Celma, M; Balaguer Martínez, JV; Castelló Pomares, ML; Contell Villagrasa, A; López García, MJ, 2003) |
| "Polycystic ovary syndrome was more common in patients on medication (38%; in 63% on VPA, in 25% on other medication) than in patients off medication (6%) or in controls (11%) (p = 0." | 1.32 | Long-term reproductive endocrine health in young women with epilepsy during puberty. ( Isojärvi, JI; Järvelä, IY; Knip, M; Mikkonen, K; Pakarinen, AJ; Tapanainen, JS; Vainionpää, LK, 2004) |
| " As increasing numbers of bipolar patients are in long-term treatment with valproate, there is an important need for further research that clarifies the relationship between long-term administration of valproate and other mood stabilizers and the potential development of reproductive endocrinologic abnormalities, and for increased awareness among clinicians and patients of the unknown potential for these worrisome side-effects." | 1.31 | Valproate treatment and the risk of hyperandrogenism and polycystic ovaries. ( Soares, JC, 2000) |
| "A possible role of the seizure disorder or, alternatively, of the use of antiepileptic drugs (AEDs) has been suggested as the pathogenic mechanism." | 1.31 | Characterization of reproductive endocrine disorders in women with epilepsy. ( Bilo, L; Di Carlo, C; Meo, R; Nappi, C; Striano, S; Valentino, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 23 (69.70) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rauchenzauner, M | 1 |
| Roscia, S | 1 |
| Prieschl, M | 1 |
| Wildt, L | 1 |
| Haberlandt, E | 1 |
| Baumann, M | 1 |
| Rostasy, K | 1 |
| Agostinelli, S | 1 |
| Pizzolorusso, A | 1 |
| Luef, G | 2 |
| Verrotti, A | 1 |
| Zhang, L | 1 |
| Li, H | 1 |
| Li, S | 1 |
| Zou, X | 1 |
| Chandrareddy, A | 1 |
| Muneyyirci-Delale, O | 1 |
| Morrell, MJ | 1 |
| Hayes, FJ | 1 |
| Sluss, PM | 1 |
| Adams, JM | 3 |
| Bhatt, M | 1 |
| Ozkara, C | 1 |
| Warnock, CR | 1 |
| Isojärvi, J | 2 |
| Gorkemli, H | 1 |
| Genc, BO | 1 |
| Dogan, EA | 1 |
| Genc, E | 1 |
| Ozdemir, S | 1 |
| Balaguer Martínez, JV | 1 |
| López García, MJ | 1 |
| Andrés Celma, M | 1 |
| Contell Villagrasa, A | 1 |
| Castelló Pomares, ML | 1 |
| Mikkonen, K | 2 |
| Vainionpää, LK | 2 |
| Pakarinen, AJ | 8 |
| Knip, M | 7 |
| Järvelä, IY | 1 |
| Tapanainen, JS | 7 |
| Isojärvi, JI | 10 |
| El-Khayat, HA | 1 |
| Abd El-Basset, FZ | 1 |
| Tomoum, HY | 1 |
| Tohamy, SM | 1 |
| Zaky, AA | 1 |
| Mohamed, MS | 1 |
| Hakky, SM | 1 |
| El Barbary, NS | 1 |
| Nassef, NM | 1 |
| Rasgon, NL | 1 |
| Reynolds, MF | 1 |
| Elman, S | 1 |
| Saad, M | 1 |
| Frye, MA | 1 |
| Bauer, M | 1 |
| Altshuler, LL | 1 |
| Joffe, H | 2 |
| Cohen, LS | 2 |
| Suppes, T | 2 |
| McLaughlin, WL | 1 |
| Lavori, P | 1 |
| Hwang, CH | 2 |
| Hall, JE | 2 |
| Sachs, GS | 2 |
| Seki, A | 1 |
| Inoue, T | 1 |
| Maegaki, Y | 1 |
| Sugiura, C | 1 |
| Toyoshima, M | 1 |
| Akaboshi, S | 1 |
| Ohno, K | 1 |
| Molay, F | 1 |
| Löfgren, E | 1 |
| Tolonen, U | 1 |
| Pakarinen, A | 1 |
| Koivunen, R | 3 |
| Myllyla, VV | 7 |
| Prabhakar, S | 1 |
| Sahota, P | 1 |
| Kharbanda, PS | 1 |
| Siali, R | 1 |
| Jain, V | 1 |
| Lal, V | 1 |
| Khurana, D | 1 |
| Bahtiyar, G | 1 |
| Weiss, K | 1 |
| Sacerdote, AS | 1 |
| Laatikainen, TJ | 3 |
| Juntunen, KT | 2 |
| Garland, EJ | 1 |
| Behr, R | 1 |
| Rättyä, J | 4 |
| Tekay, A | 2 |
| Eberle, AJ | 1 |
| Lanning, P | 1 |
| Bodensteiner, JB | 1 |
| Piontek, CM | 1 |
| Wisner, KL | 2 |
| Turkka, J | 1 |
| Kotila, MA | 1 |
| Lukkarinen, O | 1 |
| Soares, JC | 1 |
| Gracious, BL | 1 |
| Betts, T | 1 |
| Taubøll, E | 2 |
| Bilo, L | 1 |
| Meo, R | 1 |
| Valentino, R | 1 |
| Di Carlo, C | 1 |
| Striano, S | 1 |
| Nappi, C | 1 |
| van Parys, J | 1 |
| Harbo, HF | 1 |
| Dale, PO | 1 |
| Fauser, BC | 1 |
| Gjerstad, L | 1 |
| Abraham, I | 1 |
| Trinka, E | 1 |
| Alge, A | 1 |
| Windisch, J | 1 |
| Daxenbichler, G | 1 |
| Unterberger, I | 1 |
| Seppi, K | 1 |
| Lechleitner, M | 1 |
| Krämer, G | 1 |
| Bauer, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)[NCT00012558] | 5,000 participants | Interventional | 1998-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Hyperandrogenism
| Article | Year |
|---|---|
Reproductive and metabolic abnormalities in women taking valproate for bipolar disorder: a meta-analysis.
Topics: Bipolar Disorder; Female; Humans; Hyperandrogenism; Menstruation Disturbances; Metabolic Diseases; P | 2016 |
On the association between valproate and polycystic ovary syndrome: a response and an alternative view.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Comorbidity; Epilepsy; Female; Fertility; Humans | 2001 |
2 trials available for valproic acid and Hyperandrogenism
| Article | Year |
|---|---|
Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine.
Topics: Adolescent; Adult; Anovulation; Epilepsy; Female; Humans; Hyperandrogenism; Internationality; Lamotr | 2008 |
Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder.
Topics: Adolescent; Adult; Amenorrhea; Antimanic Agents; Bipolar Disorder; Cohort Studies; Comorbidity; Fema | 2006 |
29 other studies available for valproic acid and Hyperandrogenism
| Article | Year |
|---|---|
Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen?
Topics: Adiposity; Adolescent; Anticonvulsants; Cohort Studies; Cross-Sectional Studies; Drug Evaluation, Pr | 2014 |
Risks versus benefits of valproic acid?
Topics: 3-Hydroxysteroid Dehydrogenases; Analgesics; Endometriosis; Enzyme Inhibitors; Female; Humans; Hyper | 2008 |
Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hype | 2009 |
[Effects of valproate on sexual development].
Topics: Age Determination by Skeleton; Anthropometry; Anticonvulsants; Child; Epilepsy; Female; Gonadal Ster | 2003 |
Long-term reproductive endocrine health in young women with epilepsy during puberty.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Comorbidity; Epilepsy; Female; Finland; Follow-U | 2004 |
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dehydroepiandrosterone; Epilepsy; Female; Growth; | 2004 |
Longitudinal evaluation of reproductive function in women treated for bipolar disorder.
Topics: Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Cross-Sectional Studies | 2005 |
[Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman].
Topics: Adenoma, Liver Cell; Adult; Epilepsy; Female; Humans; Hyperandrogenism; Liver Neoplasms; Polycystic | 2006 |
Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report.
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Body Mass Index; Female; Follow-Up Studies; H | 2006 |
Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism | 2007 |
Sodium valproate, hyperandrogenism and altered ovarian function in Indian women with epilepsy: a prospective study.
Topics: Body Mass Index; Epilepsy; Female; Follow-Up Studies; Hirsutism; Humans; Hyperandrogenism; Indians, | 2007 |
Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adult; Aged; Antipsychotic Agents; Cortodo | 2007 |
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Cross-Sectional Studies; Epilepsies, Partial | 1993 |
Obesity and endocrine disorders in women taking valproate for epilepsy.
Topics: Adult; Body Weight; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Endocrine | 1996 |
Hormonal effects of valproic acid?
Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Child; Female; Follow-Up Studies; Humans; Hyp | 1996 |
Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.
Topics: Analysis of Variance; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Follow-Up Studies; Humans | 1998 |
Valproate and polycystic ovaries.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ov | 1998 |
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Hyperandrogenism; Insulin; Insulin-Like Growth Factor B | 1999 |
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Epilepsy; Female; Humans; Hyperandrogenism; Puberty; Sexual Maturation; Valproic Acid | 1999 |
Appropriate clinical management of women taking valproate.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Epilepsy; Female; Humans; Hyperandrogenism; Insuli | 2000 |
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Electroencephalography; Epilepsy; Female; Humans; H | 2000 |
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.
Topics: Adolescent; Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; | 2001 |
Valproate treatment and the risk of hyperandrogenism and polycystic ovaries.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ovary Syndrome; Risk | 2000 |
Valproate and the risk of hyperandrogenism.
Topics: Anticonvulsants; Female; Humans; Hyperandrogenism; Valproic Acid | 2001 |
Case reports.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anticonvulsants; Child; Diagnosis, Differential; Epileps | 2001 |
Characterization of reproductive endocrine disorders in women with epilepsy.
Topics: Adolescent; Adult; Amenorrhea; Anticonvulsants; Endocrine System Diseases; Epilepsy; Female; Humans; | 2001 |
[The dangers of valproate in women].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Humans; Hyperandro | 1998 |
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Cardiovascular Diseases; Case-Control S | 2001 |
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate.
Topics: Adult; Anticonvulsants; Body Mass Index; Body Weight; Confidence Intervals; Cross-Sectional Studies; | 2002 |