valproic acid has been researched along with Hyperactivity, Motor in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 7.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "The objectives of this study were to determine whether autistic children taking levetiracetam (1) showed improvement in the areas of aggression, impulsivity, hyperkinesis, and mood instability, and (2) showed a nootropic response." | 5.10 | Levetiracetam in autistic children: an open-label study. ( Rugino, TA; Samsock, TC, 2002) |
| "A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment." | 3.71 | Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. ( Belmaker, RH; Einat, H; Shaldubina, A; Shimon, H; Szechtman, H, 2002) |
| "Chorea in Huntington's Disease (HD) is usually treated with antidopaminergic neuroleptics like haloperidol, olanzapine and tiaprid or dopamine depleting drugs like tetrabenazine." | 2.72 | Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series. ( Andrich, JE; Kraus, PH; Lauter, T; Przuntek, H; Saft, C, 2006) |
| " Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities." | 1.42 | Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. ( Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L, 2015) |
| "Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function." | 1.39 | SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. ( Breman, AM; Chen, H; Cheung, SW; Han, K; Hao, S; Holder, JL; Kang, H; Lu, H; Lu, HC; Patel, A; Schaaf, CP; Sun, H; Tang, J; Wu, Z; Yu, P; Zoghbi, HY, 2013) |
| "Treatment with haloperidol in all patients and with dipropylacetic acid in three patients did not appear to modify the CSF, HVA, and 5HIAA concentrations, the plasma DBH activity, or the DA uptake." | 1.26 | Biochemical aspects of Huntington's chorea. ( Algeri, S; Branciforti, A; Calderini, G; Caraceni, T; Consolazione, A; Dall'olio, A; Girotti, F; Morselli, PL; Riva, E; Spreafico, R, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asth, L | 1 |
| Tiago, PRF | 1 |
| Costa, LRF | 1 |
| Holanda, VAD | 1 |
| Pacifico, S | 1 |
| Zaveri, NT | 1 |
| Calo', G | 1 |
| Ruzza, C | 1 |
| Gavioli, EC | 1 |
| Han, K | 1 |
| Holder, JL | 1 |
| Schaaf, CP | 1 |
| Lu, H | 1 |
| Chen, H | 1 |
| Kang, H | 1 |
| Tang, J | 1 |
| Wu, Z | 1 |
| Hao, S | 1 |
| Cheung, SW | 1 |
| Yu, P | 1 |
| Sun, H | 1 |
| Breman, AM | 1 |
| Patel, A | 1 |
| Lu, HC | 1 |
| Zoghbi, HY | 1 |
| Maksimovic, M | 1 |
| Vekovischeva, OY | 1 |
| Aitta-aho, T | 1 |
| Korpi, ER | 1 |
| Xing, B | 1 |
| Liang, XP | 1 |
| Liu, P | 1 |
| Zhao, Y | 1 |
| Chu, Z | 1 |
| Dang, YH | 1 |
| Zhou, R | 1 |
| Lu, Y | 1 |
| Han, Y | 1 |
| Li, X | 1 |
| Lou, H | 1 |
| Zhu, L | 1 |
| Zhen, X | 1 |
| Duan, S | 1 |
| Kim, JW | 1 |
| Seung, H | 1 |
| Kim, KC | 1 |
| Gonzales, ELT | 1 |
| Oh, HA | 1 |
| Yang, SM | 1 |
| Ko, MJ | 1 |
| Han, SH | 1 |
| Banerjee, S | 1 |
| Shin, CY | 1 |
| Gomes, LM | 1 |
| Carvalho-Silva, M | 1 |
| Teixeira, LJ | 1 |
| Rebelo, J | 1 |
| Mota, IT | 1 |
| Bilesimo, R | 1 |
| Michels, M | 1 |
| Arent, CO | 1 |
| Mariot, E | 1 |
| Dal-Pizzol, F | 1 |
| Scaini, G | 1 |
| Quevedo, J | 1 |
| Streck, EL | 1 |
| Miller, JS | 1 |
| Tallarida, RJ | 1 |
| Unterwald, EM | 1 |
| Douma, TN | 1 |
| Kolarz, A | 1 |
| Postma, Y | 1 |
| Olivier, B | 1 |
| Groenink, L | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| Rugino, TA | 1 |
| Samsock, TC | 1 |
| Ralph-Williams, RJ | 1 |
| Paulus, MP | 1 |
| Zhuang, X | 1 |
| Hen, R | 1 |
| Geyer, MA | 1 |
| Saft, C | 1 |
| Lauter, T | 1 |
| Kraus, PH | 1 |
| Przuntek, H | 1 |
| Andrich, JE | 1 |
| Brandt, C | 1 |
| Gastens, AM | 1 |
| Sun, Mz | 1 |
| Hausknecht, M | 1 |
| Löscher, W | 1 |
| Kim, WY | 1 |
| Kim, S | 1 |
| Kim, JH | 1 |
| Zoran, DL | 1 |
| Boeckh, A | 1 |
| Boothe, DM | 1 |
| Swann, AC | 1 |
| Bowden, CL | 1 |
| Calabrese, JR | 1 |
| Dilsaver, SC | 1 |
| Morris, DD | 1 |
| Shaldubina, A | 1 |
| Einat, H | 1 |
| Szechtman, H | 1 |
| Shimon, H | 1 |
| Belmaker, RH | 1 |
| Caraceni, T | 1 |
| Calderini, G | 1 |
| Consolazione, A | 1 |
| Riva, E | 1 |
| Algeri, S | 1 |
| Girotti, F | 1 |
| Spreafico, R | 1 |
| Branciforti, A | 1 |
| Dall'olio, A | 1 |
| Morselli, PL | 1 |
| Goulden, KJ | 1 |
| Dooley, JM | 1 |
| Camfield, PR | 1 |
| Fraser, AD | 1 |
3 trials available for valproic acid and Hyperactivity, Motor
| Article | Year |
|---|---|
Levetiracetam in autistic children: an open-label study.
Topics: Aggression; Anticonvulsants; Autistic Disorder; Cetirizine; Child; Child Behavior Disorders; Child, | 2002 |
Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Huntington Disease; Hyperk | 2006 |
Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania.
Topics: Adult; Antimanic Agents; Behavior; Bipolar Disorder; Delusions; Double-Blind Method; Euphoria; Femal | 2002 |
17 other studies available for valproic acid and Hyperactivity, Motor
| Article | Year |
|---|---|
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Female; Hyperkinesis; Imidazoles; Methylphenidate; Mice | 2020 |
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.
Topics: Actin-Related Protein 2-3 Complex; Actins; Adult; Animals; Behavior, Animal; Bipolar Disorder; Chrom | 2013 |
Chronic treatment with mood-stabilizers attenuates abnormal hyperlocomotion of GluA1-subunit deficient mice.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Female; Hyperkinesis; Lithium; Mal | 2014 |
Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3β Signaling in the Nucleus Accumbens Core.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Glycogen Synthase Kinase 3; Glycogen S | 2015 |
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; D | 2015 |
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism.
Topics: Agmatine; Animals; Autism Spectrum Disorder; Disease Models, Animal; Grooming; Hippocampus; Hyperkin | 2017 |
Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration.
Topics: Amphetamines; Animals; Antimanic Agents; Appetite Depressants; Behavior, Animal; Brain Chemistry; Fa | 2017 |
Cocaine-induced hyperactivity and sensitization are dependent on GSK3.
Topics: Animals; Caudate Nucleus; Cocaine; Cocaine-Related Disorders; Enzyme Activation; Glycogen Synthase K | 2009 |
The amphetamine-chlordiazepoxide mixture, a pharmacological screen for mood stabilizers, does not enhance amphetamine-induced disruption of prepulse inhibition.
Topics: Acoustic Stimulation; Affect; Amphetamine; Analysis of Variance; Animals; Anticonvulsants; Antimanic | 2011 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system.
Topics: Animals; Antimanic Agents; Behavior, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; | 2003 |
Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Cell Death; Disease Models, Animal; Dose-Re | 2006 |
Chronic microinjection of valproic acid into the nucleus accumbens attenuates amphetamine-induced locomotor activity.
Topics: Amphetamine; Animals; Anticonvulsants; Central Nervous System Stimulants; Disease Models, Animal; Dr | 2008 |
Hyperactivity and alopecia associated with ingestion of valproic acid in a cat.
Topics: Alopecia; Animals; Anticonvulsants; Behavior, Animal; Cat Diseases; Cats; Hyperkinesis; Male; Valpro | 2001 |
Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder.
Topics: Administration, Oral; Animals; Anticonvulsants; Bipolar Disorder; Brain; Carbamazepine; Disease Mode | 2002 |
Biochemical aspects of Huntington's chorea.
Topics: Adult; Age Factors; Blood Platelets; Brain Damage, Chronic; Dopamine; Dopamine beta-Hydroxylase; Fem | 1977 |
Clinical valproate toxicity induced by acetylsalicylic acid.
Topics: Adolescent; Aspirin; Child; Child, Preschool; Drug Interactions; Epilepsy, Temporal Lobe; Female; Hu | 1987 |