valproic acid has been researched along with Hepatitis C in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 30-year-old man with bipolar disorder and HIV initiated treatment with lopinavir/ritonavir, zidovudine, and lamivudine." | 7.73 | Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder. ( Allan, J; Brouillette, MJ; Delisle, MS; Sheehan, NL, 2006) |
| "ALT elevations with valproic acid were significantly greater among patients with positive hepatitis C status than those with negative or unknown status." | 7.72 | The safety of valproic acid use for patients with hepatitis C infection. ( Barnes, RF; Dominitz, JA; Felker, BL; Sloan, KL, 2003) |
| "A 30-year-old man with bipolar disorder and HIV initiated treatment with lopinavir/ritonavir, zidovudine, and lamivudine." | 3.73 | Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder. ( Allan, J; Brouillette, MJ; Delisle, MS; Sheehan, NL, 2006) |
| "ALT elevations with valproic acid were significantly greater among patients with positive hepatitis C status than those with negative or unknown status." | 3.72 | The safety of valproic acid use for patients with hepatitis C infection. ( Barnes, RF; Dominitz, JA; Felker, BL; Sloan, KL, 2003) |
| "Valproic acid has been implicated in at least 100 cases of fatal acute liver failure." | 1.28 | Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy. ( Bacon, BR; Gholson, CF; Gonzalez, E; Netchvolodoff, CV; Ray, M; Scott, DA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Felker, BL | 1 |
| Sloan, KL | 1 |
| Dominitz, JA | 1 |
| Barnes, RF | 1 |
| Sheehan, NL | 1 |
| Brouillette, MJ | 1 |
| Delisle, MS | 1 |
| Allan, J | 1 |
| Lott, RS | 1 |
| Helmboldt, KM | 1 |
| Madaras-Kelly, KJ | 1 |
| Scott, DA | 1 |
| Gholson, CF | 1 |
| Netchvolodoff, CV | 1 |
| Ray, M | 1 |
| Gonzalez, E | 1 |
| Bacon, BR | 1 |
4 other studies available for valproic acid and Hepatitis C
| Article | Year |
|---|---|
The safety of valproic acid use for patients with hepatitis C infection.
Topics: Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Hepa | 2003 |
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.
Topics: Adult; Antiretroviral Therapy, Highly Active; Bipolar Disorder; Dose-Response Relationship, Drug; Dr | 2006 |
Retrospective evaluation of the effect of valproate therapy on transaminase elevations in patients with hepatitis C.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chi-Squar | 2001 |
Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy.
Topics: Adult; Fatty Liver; Hepatitis C; Hepatitis, Chronic; Humans; Male; Seizures; Valproic Acid | 1991 |