valproic acid and Hemorrhagic Shock studies

valproic acid and Hemorrhagic Shock

valproic acid has been researched along with Hemorrhagic Shock in 49 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

Excerpt	Relevance	Reference
" Valproic acid (VPA) alleviates hemorrhagic shock (HS)-induced ALI (HS/ALI) and inhibits TF expression in monocytes."	8.31	VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. ( Chong, W; Liu, C; Shao, L; Wu, B, 2023)
"Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma."	7.88	Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Dennahy, IS; Georgoff, PE; Ghandour, MH; Higgins, GA; Nikolian, VC; Remmer, H; Weykamp, M, 2018)
"We have previously shown that resuscitation with fresh frozen plasma (FFP) in a large animal model of traumatic brain injury (TBI) and hemorrhagic shock (HS) decreases the size of the brain lesion, and that addition of a histone deacetylase inhibitor, valproic acid (VPA), provides synergistic benefits."	7.80	Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Boer, C; Dekker, SE; Halaweish, I; Jin, G; Johansson, PI; Linzel, D; Liu, B; Sillesen, M, 2014)
"Valproic acid (VPA) has been shown to improve survival in animal models of hemorrhagic shock at a dose of 300 mg/kg."	7.80	Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study. ( Alam, HB; Halaweish, I; Hwabejire, JO; Li, Y; Liu, B; Lu, J, 2014)
"We have demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve animal survival after hemorrhagic shock and protect neurons from hypoxia-induced apoptosis."	7.74	Cell protective mechanism of valproic acid in lethal hemorrhagic shock. ( Alam, HB; Butt, MU; deMoya, M; Li, Y; Liu, B; Sailhamer, EA; Shuja, F; Shults, C; Velmahos, GC; Yuan, Z, 2008)
"Valproic acid-treated animals had significantly less neurologic impairment on days 2 (16."	7.30	Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Chtraklin, K; Dimonte, D; Ho, JW; Jin, G; Joaquin, TA; Keeney-Bonthrone, TP; Latif, Z; Ober, RA; Pai, MP; Vercruysse, C; Wen, B, 2023)
"Valproic acid (VPA) has been extensively used for treatment of anxiety and seizure."	5.72	Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival. ( Bynum, J; Cap, AP; Martini, WZ; Ryan, KL; Xia, H, 2022)
"Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs."	5.62	Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021)
"Combined traumatic brain injury and hemorrhagic shock are highly lethal."	5.48	Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Dekker, SE; Dennahy, IS; Georgoff, PE; Higgins, GA; Nikolian, VC; Williams, AM, 2018)
"Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma."	5.48	Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. ( Alam, HB; Athey, B; Chtraklin, K; Eidy, H; Georgoff, PE; Ghandour, MH; Higgins, G; Nikolian, VC; Williams, A, 2018)
"Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0."	5.46	Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017)
"Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury."	5.43	Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; de Vries, HE; Dekker, SE; Jin, G; Johnson, CN; Li, Y; Liu, B; Sillesen, M, 2016)
"Traumatic brain injury (TBI) and hemorrhagic shock (HS) are major causes of trauma-related deaths and are especially lethal as a combined insult."	5.39	Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; deMoya, MA; DePeralta, D; Duggan, M; Hwabejire, JO; Imam, AM; Jepsen, CH; Jin, G; Liu, B; Lu, J; Sillesen, M; Socrate, S, 2013)
"Wistar-Kyoto rats underwent hemorrhagic shock (60% blood loss) followed by treatment with or without VPA (300 mg/kg)."	5.36	Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment. ( Alam, HB; deMoya, M; Dillon, ST; Fukudome, EY; Kheirbek, T; Li, Y; Libermann, TA; Liu, B; Sailhamer, EA; Velmahos, G, 2010)
" Valproic acid (VPA) alleviates hemorrhagic shock (HS)-induced ALI (HS/ALI) and inhibits TF expression in monocytes."	4.31	VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. ( Chong, W; Liu, C; Shao, L; Wu, B, 2023)
"We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain lesion size and swelling following traumatic brain injury (TBI) and hemorrhagic shock (HS)."	4.02	Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; Biesterveld, BE; Dekker, SE; Johnson, CN; Li, Y; Liu, B; Sillesen, M; Tagett, R; Williams, AM, 2021)
" The histone deacetylase inhibitor, high-dose valproic acid (VPA) has been shown to have cytoprotective potential in models of combined TBI and hemorrhagic shock, but it has not been tested in an isolated TBI model."	3.96	Valproic acid treatment rescues injured tissues after traumatic brain injury. ( Alam, HB; Biesterveld, BE; Iancu, A; Kemp, MT; O'Connell, RL; Pai, MP; Pumiglia, L; Remmer, HA; Shamshad, AA; Siddiqui, AZ; Wakam, GK; Williams, AM, 2020)
" Nonselective histone deacetylase inhibitors (HDACIs), such as valproic acid (VPA), have been shown to improve outcomes in hemorrhagic shock (HS)."	3.88	Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model. ( Alam, HB; Bhatti, UF; Chang, P; Dennahy, IS; Li, Y; Liu, B; Nikolian, VC; Weykamp, M; Williams, AM, 2018)
"Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma."	3.88	Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Dennahy, IS; Georgoff, PE; Ghandour, MH; Higgins, GA; Nikolian, VC; Remmer, H; Weykamp, M, 2018)
"To determine the mechanism of action of valproic acid (VPA) in the adult central nervous system (CNS) following traumatic brain injury (TBI) and hemorrhagic shock (HS)."	3.85	Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury. ( Alam, HE; Allyn-Feuer, A; Athey, BD; Georgoff, P; Higgins, GA; Higgins, R; Nikolian, V; Pauls, B, 2017)
"Therapeutic hypothermia (hypo) and valproic acid (VPA, a histone deacetylase inhibitor) have independently been shown to be protective in models of trauma and hemorrhagic shock but require logistically challenging doses to be effective."	3.81	Hypothermia and valproic acid activate prosurvival pathways after hemorrhage. ( Alam, HB; Bambakidis, T; Chtraklin, K; Dekker, SE; Li, Y; Linzel, D; Liu, B; Maxwell, J, 2015)
"To investigate the consequences of histone deacetylase inhibition by histone deacetylase inhibitor valproic acid and IκB kinase/nuclear factor-κB signaling blockade by IκB kinase inhibitor BAY11-7082 on (microvascular) endothelial cell behavior in vitro as well as in mice subjected to hemorrhagic shock/resuscitation in vivo."	3.81	Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice. ( Aslan, A; Jongman, RM; Li, R; Molema, G; Moorlag, HE; Moser, J; van Meurs, M; Yan, R; Zijlstra, JG; Zwiers, PJ, 2015)
"We have previously shown that addition of valproic acid (VPA; a histone deacetylase inhibitor) to hetastarch (Hextend [HEX]) resuscitation significantly decreases lesion size in a swine model of traumatic brain injury (TBI) and hemorrhagic shock (HS)."	3.80	Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage. ( Alam, HB; Bambakidis, T; Dekker, SE; Jin, G; Johnson, CN; Li, Y; Liu, B; Sillesen, M, 2014)
"We have previously shown that resuscitation with fresh frozen plasma (FFP) in a large animal model of traumatic brain injury (TBI) and hemorrhagic shock (HS) decreases the size of the brain lesion, and that addition of a histone deacetylase inhibitor, valproic acid (VPA), provides synergistic benefits."	3.80	Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Boer, C; Dekker, SE; Halaweish, I; Jin, G; Johansson, PI; Linzel, D; Liu, B; Sillesen, M, 2014)
"We have previously demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival after hemorrhagic shock (HS), protect neurons from hypoxia-induced apoptosis, and attenuate the inflammatory response."	3.78	Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. ( Alam, HB; Demoya, MA; Duggan, M; Hwabejire, J; Imam, A; Jepsen, CH; Jin, G; Liu, B; Lu, J; Mejaddam, AY; Sillesen, M; Smith, WM; Socrate, S; Velmahos, GC, 2012)
"We have demonstrated previously that valproic acid (VPA), a histone deacetylase inhibitor, can improve survival in lethal models of hemorrhagic shock."	3.75	Surviving blood loss without blood transfusion in a swine poly-trauma model. ( Alam, HB; Butt, MU; Demoya, M; Duggan, M; Fukudome, EY; Li, Y; Liu, B; Shuja, F; Velmahos, GC; Zacharias, N, 2009)
"We have demonstrated that valproic acid (VPA), a histone deacetylase inhibitor (HDACI), can improve animal survival after hemorrhagic shock, and protect neurons from hypoxia-induced apoptosis."	3.75	Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock. ( Alam, HB; Butt, MU; DeMoya, M; King, DR; Li, Y; Liu, B; Sailhamer, EA; Shuja, F; Velmahos, GC, 2009)
"Valproic acid-treated animals had significantly less neurologic impairment on days 2 (16."	3.30	Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Chtraklin, K; Dimonte, D; Ho, JW; Jin, G; Joaquin, TA; Keeney-Bonthrone, TP; Latif, Z; Ober, RA; Pai, MP; Vercruysse, C; Wen, B, 2023)
"Valproic acid (VPA) has been extensively used for treatment of anxiety and seizure."	1.72	Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival. ( Bynum, J; Cap, AP; Martini, WZ; Ryan, KL; Xia, H, 2022)
"Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs."	1.62	Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021)
"Valproic acid (VPA) has been shown to attenuate brain lesion size and swelling within the first few hours following TBI."	1.62	Pharmacologic modulation of brain metabolism by valproic acid can induce a neuroprotective environment. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Dennahy, IS; Kachman, M; Karnovsky, A; Li, Y; Liu, B; Nikolian, VC; O'Connell, RL; Siddiqui, A; Williams, AM, 2021)
"Valproic acid (VPA) has been shown to have beneficial properties in lethal hemorrhage/trauma models."	1.51	Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Dennahy, IS; Graham, NJ; Kathawate, RG; Li, Y; Russo, RM; Vercruysse, CA; Williams, AM; Zhou, J, 2019)
"Valproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma."	1.48	Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. ( Alam, HB; Athey, B; Chtraklin, K; Eidy, H; Georgoff, PE; Ghandour, MH; Higgins, G; Nikolian, VC; Williams, A, 2018)
"Combined traumatic brain injury and hemorrhagic shock are highly lethal."	1.48	Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Dekker, SE; Dennahy, IS; Georgoff, PE; Higgins, GA; Nikolian, VC; Williams, AM, 2018)
"Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0."	1.46	Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017)
"Valproic acid (VPA) has been associated with improved outcomes in multiple models of trauma, when combined with isotonic fluid resuscitation."	1.46	Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock. ( Alam, HB; Dennahy, IS; Duan, X; Duggan, MJ; Georgoff, PE; Li, Y; Liu, B; Mesar, T; Nikolian, VC; Pan, B; Wu, X, 2017)
"Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury."	1.43	Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; de Vries, HE; Dekker, SE; Jin, G; Johnson, CN; Li, Y; Liu, B; Sillesen, M, 2016)
"Traumatic brain injury (TBI) and hemorrhagic shock (HS) are major causes of trauma-related deaths and are especially lethal as a combined insult."	1.39	Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; deMoya, MA; DePeralta, D; Duggan, M; Hwabejire, JO; Imam, AM; Jepsen, CH; Jin, G; Liu, B; Lu, J; Sillesen, M; Socrate, S, 2013)
"In a clinically relevant lethal polytrauma model, administration of SDP significantly improves survival without any long-term organ dysfunction or complications."	1.37	Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model. ( Alam, HB; Bramos, A; Chong, W; Duggan, M; Fikry, K; Fukudome, EY; Hamwi, KB; Kim, K; Lu, J; Velmahos, G, 2011)
"Here a case of hemorrhagic shock and fulminant hepatic failure in a patient treated with valproate is presented."	1.29	[Hemorrhagic shock and fulminant hepatic failure associated with valproate]. ( Fernandez-Fernandez, FJ; Garcia-Jimenez, A; Garcia-Rego, J; Sesma, P, 1995)

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.04)	18.2507
2000's	6 (12.24)	29.6817
2010's	33 (67.35)	24.3611
2020's	9 (18.37)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (2.04)

18.2507

2000's

6 (12.24)

29.6817

2010's

33 (67.35)

24.3611

2020's

9 (18.37)

2.80

Authors

Authors	Studies
Martini, WZ	1
Xia, H	1
Ryan, KL	1
Bynum, J	1
Cap, AP	1
Shao, L	3
Wu, B	3
Liu, C	3
Chong, W	5
Jin, G	7
Ho, JW	1
Keeney-Bonthrone, TP	1
Pai, MP	5
Wen, B	1
Ober, RA	1
Dimonte, D	1
Chtraklin, K	9
Joaquin, TA	1
Latif, Z	1
Vercruysse, C	1
Alam, HB	38
Biesterveld, BE	8
Williams, AM	10
Dennahy, IS	9
Graham, NJ	2
Siddiqui, AZ	4
OʼConnell, RL	1
Bhatti, UF	8
Liu, B	25
Russo, RM	2
Li, Y	26
Russo, R	1
Kemp, M	1
Pai, M	1
Wakam, G	1
Biesterveld, B	1
Kemp, MT	3
Wakam, GK	3
O'Connell, RL	4
Shamshad, A	1
Pumiglia, L	1
Iancu, A	1
Shamshad, AA	1
Remmer, HA	1
Dekker, SE	8
Bambakidis, T	9
Tagett, R	1
Johnson, CN	3
Sillesen, M	10
Karnovsky, A	1
Kachman, M	1
Nikolian, VC	10
Siddiqui, A	1
Srinivasan, A	3
Vercruysse, CA	2
Pan, B	1
Mesar, T	1
Georgoff, PE	6
Duan, X	2
Wu, X	1
Duggan, MJ	1
Eidy, H	2
Ghandour, MH	3
Han, Y	1
Schober, P	1
Higgins, GA	3
Andjelkovic, AV	2
Higgins, G	1
Williams, A	1
Athey, B	1
Chang, P	2
Weykamp, M	2
Remmer, H	1
Lee, J	1
Zhou, J	1
Kathawate, RG	1
Hwabejire, JO	3
Imam, AM	2
Duggan, M	5
Deperalta, D	2
Jepsen, CH	3
Lu, J	7
deMoya, MA	4
Socrate, S	2
Halaweish, I	5
Liu, Z	1
Deperalta, DK	1
Zhou, P	1
Boer, C	1
Johansson, PI	1
Linzel, D	2
Maxwell, J	1
Li, R	1
Aslan, A	1
Yan, R	1
Jongman, RM	1
Moser, J	1
Zwiers, PJ	1
Moorlag, HE	1
Zijlstra, JG	1
Molema, G	1
van Meurs, M	1
Zuckermann, AM	1
La Ragione, RM	1
Baines, DL	1
Williams, RS	1
Chang, Z	1
Wei, H	1
Bonthrone, T	1
Bonham, T	1
de Vries, HE	1
Piascik, P	1
Georgoff, P	1
Nikolian, V	1
Allyn-Feuer, A	1
Pauls, B	1
Higgins, R	1
Athey, BD	1
Alam, HE	1
Sailhamer, EA	5
Yuan, Z	1
Shults, C	3
Velmahos, GC	7
deMoya, M	6
Shuja, F	4
Butt, MU	4
Gonzales, ER	1
Chen, H	2
Munuve, RM	1
Mehrani, T	1
Nadel, A	1
Koustova, E	2
Zacharias, N	1
Fukudome, EY	6
King, DR	1
Dillon, ST	1
Kheirbek, T	2
Velmahos, G	3
Libermann, TA	1
Kochanek, AR	3
Smith, EJ	3
Kim, K	3
Hamwi, K	1
Hamwi, KB	1
Fikry, K	1
Bramos, A	1
King, D	1
Cotton, BA	1
Hu, S	1
Hou, JY	1
Li, L	1
Yang, MX	1
Sheng, ZY	1
Causey, MW	1
Salgar, S	1
Singh, N	1
Martin, M	1
Stallings, JD	1
Imam, A	1
Hwabejire, J	1
Mejaddam, AY	1
Smith, WM	1
Lin, T	1
Rhee, P	1
Kirkpatrick, J	1
Tabbara, M	1
Fernandez-Fernandez, FJ	1
Garcia-Rego, J	1
Garcia-Jimenez, A	1
Sesma, P	1

Studies

Martini, WZ

Xia, H

Ryan, KL

Bynum, J

Cap, AP

Shao, L

Wu, B

Liu, C

Chong, W

Jin, G

Ho, JW

Keeney-Bonthrone, TP

Pai, MP

Wen, B

Ober, RA

Dimonte, D

Chtraklin, K

Joaquin, TA

Latif, Z

Vercruysse, C

Alam, HB

Biesterveld, BE

Williams, AM

Dennahy, IS

Graham, NJ

Siddiqui, AZ

OʼConnell, RL

Bhatti, UF

Liu, B

Russo, RM

Li, Y

Russo, R

Kemp, M

Pai, M

Wakam, G

Biesterveld, B

Kemp, MT

Wakam, GK

O'Connell, RL

Shamshad, A

Pumiglia, L

Iancu, A

Shamshad, AA

Remmer, HA

Dekker, SE

Bambakidis, T

Tagett, R

Johnson, CN

Sillesen, M

Karnovsky, A

Kachman, M

Nikolian, VC

Siddiqui, A

Srinivasan, A

Vercruysse, CA

Pan, B

Mesar, T

Georgoff, PE

Duan, X

Wu, X

Duggan, MJ

Eidy, H

Ghandour, MH

Han, Y

Schober, P

Higgins, GA

Andjelkovic, AV

Higgins, G

Williams, A

Athey, B

Chang, P

Weykamp, M

Remmer, H

Lee, J

Zhou, J

Kathawate, RG

Hwabejire, JO

Imam, AM

Duggan, M

Deperalta, D

Jepsen, CH

Lu, J

deMoya, MA

Socrate, S

Halaweish, I

Liu, Z

Deperalta, DK

Zhou, P

Boer, C

Johansson, PI

Linzel, D

Maxwell, J

Li, R

Aslan, A

Yan, R

Jongman, RM

Moser, J

Zwiers, PJ

Moorlag, HE

Zijlstra, JG

Molema, G

van Meurs, M

Zuckermann, AM

La Ragione, RM

Baines, DL

Williams, RS

Chang, Z

Wei, H

Bonthrone, T

Bonham, T

de Vries, HE

Piascik, P

Georgoff, P

Nikolian, V

Allyn-Feuer, A

Pauls, B

Higgins, R

Athey, BD

Alam, HE

Sailhamer, EA

Yuan, Z

Shults, C

Velmahos, GC

deMoya, M

Shuja, F

Butt, MU

Gonzales, ER

Chen, H

Munuve, RM

Mehrani, T

Nadel, A

Koustova, E

Zacharias, N

Fukudome, EY

King, DR

Dillon, ST

Kheirbek, T

Velmahos, G

Libermann, TA

Kochanek, AR

Smith, EJ

Kim, K

Hamwi, K

Hamwi, KB

Fikry, K

Bramos, A

King, D

Cotton, BA

Hu, S

Hou, JY

Li, L

Yang, MX

Sheng, ZY

Causey, MW

Salgar, S

Singh, N

Martin, M

Stallings, JD

Imam, A

Hwabejire, J

Mejaddam, AY

Smith, WM

Lin, T

Rhee, P

Kirkpatrick, J

Tabbara, M

Fernandez-Fernandez, FJ

Garcia-Rego, J

Garcia-Jimenez, A

Sesma, P

Reviews

4 reviews available for valproic acid and Hemorrhagic Shock

Article	Year
Life on the battlefield: Valproic acid for combat applications. The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:2S Suppl 2 Topics: Animals; Armed Conflicts; Brain Injuries, Traumatic; Gene Expression; Histone Deacetylase Inhibitors	2020
Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury. Journal of neuroscience research, 2018, Volume: 96, Issue:4 Topics: Acetylation; Brain Injuries, Traumatic; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans;	2018
Coagulation changes following traumatic brain injury and shock. Danish medical journal, 2014, Volume: 61, Issue:12 Topics: Animals; Blood Coagulation; Brain Injuries; Disease Models, Animal; Humans; Platelet Activation; Sho	2014
Alternative fluids for prehospital resuscitation: "pharmacological" resuscitation fluids. The Journal of trauma, 2011, Volume: 70, Issue:5 Suppl Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Emergency Medical Services; Enzyme Inhibito	2011

Article

Year

Life on the battlefield: Valproic acid for combat applications.

The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:2S Suppl 2

Topics: Animals; Armed Conflicts; Brain Injuries, Traumatic; Gene Expression; Histone Deacetylase Inhibitors

2020

Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.

Journal of neuroscience research, 2018, Volume: 96, Issue:4

Topics: Acetylation; Brain Injuries, Traumatic; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans;

2018

Coagulation changes following traumatic brain injury and shock.

Danish medical journal, 2014, Volume: 61, Issue:12

Topics: Animals; Blood Coagulation; Brain Injuries; Disease Models, Animal; Humans; Platelet Activation; Sho

2014

Alternative fluids for prehospital resuscitation: "pharmacological" resuscitation fluids.

The Journal of trauma, 2011, Volume: 70, Issue:5 Suppl

Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Emergency Medical Services; Enzyme Inhibito

2011

Trials

1 trial available for valproic acid and Hemorrhagic Shock

Article	Year
Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock. The journal of trauma and acute care surgery, 2023, 11-01, Volume: 95, Issue:5 Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Resuscitation; Saline Solution; Shock, H	2023

Article

Year

Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock.

The journal of trauma and acute care surgery, 2023, 11-01, Volume: 95, Issue:5

Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Resuscitation; Saline Solution; Shock, H

2023

Other Studies

44 other studies available for valproic acid and Hemorrhagic Shock

Article	Year
Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival. The journal of trauma and acute care surgery, 2022, 08-01, Volume: 93, Issue:2S Suppl 1 Topics: Animals; Blood Coagulation; Disease Models, Animal; Hemorrhage; Resuscitation; Shock, Hemorrhagic; S	2022
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3 Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro	2023
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3 Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro	2023
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3 Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro	2023
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3 Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro	2023
Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage, and multiple trauma in swine. The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:5 Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; Erythr	2019
Valproic acid decreases resuscitation requirements after hemorrhage in a prolonged damage-control resuscitation model. The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:4 Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Resuscitation; Shock, Hemorrhagic; Swine; V	2020
Valproic acid treatment rescues injured tissues after traumatic brain injury. The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:6 Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Female; Glial Fibrill	2020
Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock. Shock (Augusta, Ga.), 2021, 01-01, Volume: 55, Issue:1 Topics: Animals; Blood Component Transfusion; Brain Injuries, Traumatic; Disease Models, Animal; Enzyme Inhi	2021
Pharmacologic modulation of brain metabolism by valproic acid can induce a neuroprotective environment. The journal of trauma and acute care surgery, 2021, 03-01, Volume: 90, Issue:3 Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors;	2021
Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. The journal of trauma and acute care surgery, 2021, 02-01, Volume: 90, Issue:2 Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug;	2021
Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock. Inflammation, 2017, Volume: 40, Issue:4 Topics: Animals; Caveolin 1; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Lung I	2017
Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. The journal of trauma and acute care surgery, 2017, Volume: 83, Issue:6 Topics: Animals; Brain; Brain Injuries, Traumatic; Cognition; Disease Models, Animal; Enzyme Inhibitors; Fem	2017
Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma. Critical care medicine, 2018, Volume: 46, Issue:1 Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Endothelium, Vascul	2018
Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock. The journal of trauma and acute care surgery, 2018, Volume: 84, Issue:4 Topics: Animals; Disease Models, Animal; Female; GABA Agents; Multiple Trauma; Polymerase Chain Reaction; Ra	2018
Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model. The journal of trauma and acute care surgery, 2018, Volume: 84, Issue:5 Topics: Animals; Apoptosis; Disease Models, Animal; Histone Deacetylase Inhibitors; Male; Myocardium; Phosph	2018
Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. The Journal of surgical research, 2018, Volume: 228 Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors;	2018
Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model. Journal of the American College of Surgeons, 2019, Volume: 228, Issue:3 Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase I	2019
Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation. The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:2 Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Resuscitation; Sh	2019
Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock. Surgery, 2013, Volume: 154, Issue:2 Topics: Adenosine Triphosphate; Animals; Blood Glucose; Brain; Brain Injuries; Calcium; Cerebrovascular Circ	2013
Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock. Surgery, 2013, Volume: 154, Issue:2 Topics: Animals; Brain; Brain Injuries; Female; Hemodynamics; Plasma; Resuscitation; Shock, Hemorrhagic; Swi	2013
Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study. The Journal of surgical research, 2014, Volume: 186, Issue:1 Topics: Acetylation; Animals; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthas	2014
Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model. Shock (Augusta, Ga.), 2014, Volume: 41, Issue:2 Topics: Acute Lung Injury; Animals; Ascitic Fluid; Histone Deacetylase Inhibitors; Interleukin-6; Male; Pero	2014
Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock. The Journal of surgical research, 2014, Volume: 190, Issue:1 Topics: Animals; Brain Injuries; CD40 Ligand; Disease Models, Animal; Female; Histone Deacetylase Inhibitors	2014
Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:6 Topics: Animals; Brain Chemistry; Brain Injuries; Disease Models, Animal; Female; Histone Deacetylase Inhibi	2014
Hypothermia and valproic acid activate prosurvival pathways after hemorrhage. The Journal of surgical research, 2015, Jun-01, Volume: 196, Issue:1 Topics: Acetylation; Animals; Arterial Pressure; Histone Deacetylase Inhibitors; Histones; Hypothermia, Indu	2015
Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice. Critical care medicine, 2015, Volume: 43, Issue:12 Topics: Animals; Disease Models, Animal; Endothelial Cells; Histone Deacetylase Inhibitors; Histone Deacetyl	2015
Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. British journal of pharmacology, 2015, Volume: 172, Issue:22 Topics: Apoptosis; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hy	2015
Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock. The journal of trauma and acute care surgery, 2015, Volume: 79, Issue:6 Topics: Animals; Blotting, Western; Brain Injuries; Cognition; Disease Models, Animal; Female; Hydroxyethyl	2015
Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. Journal of neurotrauma, 2016, 08-15, Volume: 33, Issue:16 Topics: Animals; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fem	2016
Valproic acid modulates platelet and coagulation function ex vivo. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2017, Volume: 28, Issue:6 Topics: Animals; Blood Coagulation; Blood Platelets; Brain Injuries; Platelet Aggregation; Shock, Hemorrhagi	2017
Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury. Pharmaceutical research, 2017, Volume: 34, Issue:8 Topics: Adult; Animals; Anticonvulsants; Brain; Brain Injuries, Traumatic; Cell Line, Tumor; Gene Expression	2017
Cell protective mechanism of valproic acid in lethal hemorrhagic shock. Surgery, 2008, Volume: 144, Issue:2 Topics: Acetylation; Animals; beta Catenin; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cytosol; Gene Ex	2008
Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock. The Journal of trauma, 2008, Volume: 65, Issue:3 Topics: Acetylation; Animals; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; His	2008
Surviving blood loss without blood transfusion in a swine poly-trauma model. Surgery, 2009, Volume: 146, Issue:2 Topics: Animals; beta Catenin; Blood Pressure; Blood Transfusion; Female; Femoral Fractures; Glycogen Syntha	2009
Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock. The Journal of surgical research, 2009, Volume: 156, Issue:2 Topics: Animals; Apoptosis; Caspase 3; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Histone Dea	2009
Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment. The Journal of surgical research, 2010, Volume: 159, Issue:1 Topics: Animals; Anticonvulsants; Biomarkers; Blotting, Western; Claudin-3; Intestinal Mucosa; Male; Membran	2010
Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2. The Journal of surgical research, 2010, Volume: 163, Issue:1 Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Histone Acetyltransferases; Histone Deacetylase	2010
Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model. The Journal of trauma, 2011, Volume: 70, Issue:3 Topics: Analysis of Variance; Animals; Blood Proteins; Blood Transfusion; Disease Models, Animal; Hemostasis	2011
Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model. The Journal of surgical research, 2012, Volume: 176, Issue:1 Topics: Animals; Apoptosis; Disease Models, Animal; Histone Deacetylase Inhibitors; Lung; Male; Mitogen-Acti	2012
[The effects of administration of valproic acid on organ function and outcome in a canine lethal hemorrhagic shock model]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:8 Topics: Animals; Blood Pressure; Blood Volume; Disease Models, Animal; Dogs; Male; Prognosis; Shock, Hemorrh	2011
Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia-reperfusion injury in a swine hemorrhagic shock model. Journal of vascular surgery, 2012, Volume: 55, Issue:4 Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Gene Exp	2012
Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury. Surgery, 2012, Volume: 152, Issue:2 Topics: Acute Lung Injury; Animals; Chemokine CXCL1; Histone Deacetylase Inhibitors; Lung; Peroxidase; Rats;	2012
Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury. The journal of trauma and acute care surgery, 2012, Volume: 73, Issue:6 Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Female; Hemodynamics; Hy	2012
Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver. Surgery, 2007, Volume: 141, Issue:6 Topics: Acetylation; Animals; Enzyme Inhibitors; Gene Expression; Histone Acetyltransferases; Histone Deacet	2007
Surviving blood loss without fluid resuscitation. The Journal of trauma, 2008, Volume: 64, Issue:3 Topics: Analysis of Variance; Animals; Chi-Square Distribution; Histone Deacetylase Inhibitors; Hydroxamic A	2008
[Hemorrhagic shock and fulminant hepatic failure associated with valproate]. Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:12 Topics: Anticonvulsants; Child; Hepatic Encephalopathy; Humans; Liver; Male; Shock, Hemorrhagic; Status Epil	1995

Article

Year

Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival.

The journal of trauma and acute care surgery, 2022, 08-01, Volume: 93, Issue:2S Suppl 1

Topics: Animals; Blood Coagulation; Disease Models, Animal; Hemorrhage; Resuscitation; Shock, Hemorrhagic; S

2022

VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.

Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3

Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro

2023

VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.

Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3

Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro

2023

VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.

Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3

Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro

2023

VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.

Shock (Augusta, Ga.), 2023, 03-01, Volume: 59, Issue:3

Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro

2023

Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage, and multiple trauma in swine.

The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:5

Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; Erythr

2019

Valproic acid decreases resuscitation requirements after hemorrhage in a prolonged damage-control resuscitation model.

The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:4

Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Resuscitation; Shock, Hemorrhagic; Swine; V

2020

Valproic acid treatment rescues injured tissues after traumatic brain injury.

The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:6

Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Female; Glial Fibrill

2020

Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock.

Shock (Augusta, Ga.), 2021, 01-01, Volume: 55, Issue:1

Topics: Animals; Blood Component Transfusion; Brain Injuries, Traumatic; Disease Models, Animal; Enzyme Inhi

2021

Pharmacologic modulation of brain metabolism by valproic acid can induce a neuroprotective environment.

The journal of trauma and acute care surgery, 2021, 03-01, Volume: 90, Issue:3

Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors;

2021

Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury.

The journal of trauma and acute care surgery, 2021, 02-01, Volume: 90, Issue:2

Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug;

2021

Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.

Inflammation, 2017, Volume: 40, Issue:4

Topics: Animals; Caveolin 1; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Lung I

2017

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.

The journal of trauma and acute care surgery, 2017, Volume: 83, Issue:6

Topics: Animals; Brain; Brain Injuries, Traumatic; Cognition; Disease Models, Animal; Enzyme Inhibitors; Fem

2017

Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma.

Critical care medicine, 2018, Volume: 46, Issue:1

Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Endothelium, Vascul

2018

Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock.

The journal of trauma and acute care surgery, 2018, Volume: 84, Issue:4

Topics: Animals; Disease Models, Animal; Female; GABA Agents; Multiple Trauma; Polymerase Chain Reaction; Ra

2018

Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model.

The journal of trauma and acute care surgery, 2018, Volume: 84, Issue:5

Topics: Animals; Apoptosis; Disease Models, Animal; Histone Deacetylase Inhibitors; Male; Myocardium; Phosph

2018

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock.

The Journal of surgical research, 2018, Volume: 228

Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors;

2018

Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model.

Journal of the American College of Surgeons, 2019, Volume: 228, Issue:3

Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase I

2019

Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation.

The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:2

Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Resuscitation; Sh

2019

Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock.

Surgery, 2013, Volume: 154, Issue:2

Topics: Adenosine Triphosphate; Animals; Blood Glucose; Brain; Brain Injuries; Calcium; Cerebrovascular Circ

2013

Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock.

Surgery, 2013, Volume: 154, Issue:2

Topics: Animals; Brain; Brain Injuries; Female; Hemodynamics; Plasma; Resuscitation; Shock, Hemorrhagic; Swi

2013

Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.

The Journal of surgical research, 2014, Volume: 186, Issue:1

Topics: Acetylation; Animals; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthas

2014

Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.

Shock (Augusta, Ga.), 2014, Volume: 41, Issue:2

Topics: Acute Lung Injury; Animals; Ascitic Fluid; Histone Deacetylase Inhibitors; Interleukin-6; Male; Pero

2014

Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.

The Journal of surgical research, 2014, Volume: 190, Issue:1

Topics: Animals; Brain Injuries; CD40 Ligand; Disease Models, Animal; Female; Histone Deacetylase Inhibitors

2014

Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage.

The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:6

Topics: Animals; Brain Chemistry; Brain Injuries; Disease Models, Animal; Female; Histone Deacetylase Inhibi

2014

Hypothermia and valproic acid activate prosurvival pathways after hemorrhage.

The Journal of surgical research, 2015, Jun-01, Volume: 196, Issue:1

Topics: Acetylation; Animals; Arterial Pressure; Histone Deacetylase Inhibitors; Histones; Hypothermia, Indu

2015

Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.

Critical care medicine, 2015, Volume: 43, Issue:12

Topics: Animals; Disease Models, Animal; Endothelial Cells; Histone Deacetylase Inhibitors; Histone Deacetyl

2015

Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.

British journal of pharmacology, 2015, Volume: 172, Issue:22

Topics: Apoptosis; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hy

2015

Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock.

The journal of trauma and acute care surgery, 2015, Volume: 79, Issue:6

Topics: Animals; Blotting, Western; Brain Injuries; Cognition; Disease Models, Animal; Female; Hydroxyethyl

2015

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.

Journal of neurotrauma, 2016, 08-15, Volume: 33, Issue:16

Topics: Animals; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fem

2016

Valproic acid modulates platelet and coagulation function ex vivo.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2017, Volume: 28, Issue:6

Topics: Animals; Blood Coagulation; Blood Platelets; Brain Injuries; Platelet Aggregation; Shock, Hemorrhagi

2017

Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury.

Pharmaceutical research, 2017, Volume: 34, Issue:8

Topics: Adult; Animals; Anticonvulsants; Brain; Brain Injuries, Traumatic; Cell Line, Tumor; Gene Expression

2017

Cell protective mechanism of valproic acid in lethal hemorrhagic shock.

Surgery, 2008, Volume: 144, Issue:2

Topics: Acetylation; Animals; beta Catenin; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cytosol; Gene Ex

2008

Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.

The Journal of trauma, 2008, Volume: 65, Issue:3

Topics: Acetylation; Animals; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; His

2008

Surviving blood loss without blood transfusion in a swine poly-trauma model.

Surgery, 2009, Volume: 146, Issue:2

Topics: Animals; beta Catenin; Blood Pressure; Blood Transfusion; Female; Femoral Fractures; Glycogen Syntha

2009

Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.

The Journal of surgical research, 2009, Volume: 156, Issue:2

Topics: Animals; Apoptosis; Caspase 3; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Histone Dea

2009

Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment.

The Journal of surgical research, 2010, Volume: 159, Issue:1

Topics: Animals; Anticonvulsants; Biomarkers; Blotting, Western; Claudin-3; Intestinal Mucosa; Male; Membran

2010

Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2.

The Journal of surgical research, 2010, Volume: 163, Issue:1

Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Histone Acetyltransferases; Histone Deacetylase

2010

Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model.

The Journal of trauma, 2011, Volume: 70, Issue:3

Topics: Analysis of Variance; Animals; Blood Proteins; Blood Transfusion; Disease Models, Animal; Hemostasis

2011

Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model.

The Journal of surgical research, 2012, Volume: 176, Issue:1

Topics: Animals; Apoptosis; Disease Models, Animal; Histone Deacetylase Inhibitors; Lung; Male; Mitogen-Acti

2012

[The effects of administration of valproic acid on organ function and outcome in a canine lethal hemorrhagic shock model].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:8

Topics: Animals; Blood Pressure; Blood Volume; Disease Models, Animal; Dogs; Male; Prognosis; Shock, Hemorrh

2011

Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia-reperfusion injury in a swine hemorrhagic shock model.

Journal of vascular surgery, 2012, Volume: 55, Issue:4

Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Gene Exp

2012

Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury.

Surgery, 2012, Volume: 152, Issue:2

Topics: Acute Lung Injury; Animals; Chemokine CXCL1; Histone Deacetylase Inhibitors; Lung; Peroxidase; Rats;

2012

Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury.

The journal of trauma and acute care surgery, 2012, Volume: 73, Issue:6

Topics: Animals; Brain Injuries; Disease Models, Animal; Drug Therapy, Combination; Female; Hemodynamics; Hy

2012

Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.

Surgery, 2007, Volume: 141, Issue:6

Topics: Acetylation; Animals; Enzyme Inhibitors; Gene Expression; Histone Acetyltransferases; Histone Deacet

2007

Surviving blood loss without fluid resuscitation.

The Journal of trauma, 2008, Volume: 64, Issue:3

Topics: Analysis of Variance; Animals; Chi-Square Distribution; Histone Deacetylase Inhibitors; Hydroxamic A

2008

[Hemorrhagic shock and fulminant hepatic failure associated with valproate].

Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:12

Topics: Anticonvulsants; Child; Hepatic Encephalopathy; Humans; Liver; Male; Shock, Hemorrhagic; Status Epil

1995