valproic acid has been researched along with Hemoglobinopathies in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hemoglobinopathies: A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aspirin was shown to increase oxygen affinity of hemoglobin via acetylating lysine residues and its general acetylating activity on proteins such as histones makes it also an interesting candidate to activate fetal hemoglobin." | 5.34 | Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. ( Altinoz, MA; Carin, MN; Gedikoglu, G; Ozdilli, K, 2007) |
| " The fact that valproic acid, a derivative of pentanoic acid, also induces gamma-globin expression suggests that short-chain fatty acid derivatives that are already approved for human use may possess the property of gamma-globin inducibility and may be of therapeutic relevance to the beta-chain hemoglobinopathies." | 3.69 | Stimulation of fetal hemoglobin production by short chain fatty acids. ( Blau, CA; Dover, G; Fournarakis, B; Josephson, B; Li, Q; Liakopoulou, E; Papayannopoulou, T; Raisys, V; Stamatoyannopoulos, G; Wolf, JA, 1995) |
| "Aspirin was shown to increase oxygen affinity of hemoglobin via acetylating lysine residues and its general acetylating activity on proteins such as histones makes it also an interesting candidate to activate fetal hemoglobin." | 1.34 | Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. ( Altinoz, MA; Carin, MN; Gedikoglu, G; Ozdilli, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okhovat, MA | 1 |
| Ziari, K | 1 |
| Ranjbaran, R | 1 |
| Nikouyan, N | 1 |
| Altinoz, MA | 1 |
| Ozdilli, K | 1 |
| Carin, MN | 1 |
| Gedikoglu, G | 1 |
| Liakopoulou, E | 1 |
| Blau, CA | 1 |
| Li, Q | 1 |
| Josephson, B | 1 |
| Wolf, JA | 1 |
| Fournarakis, B | 1 |
| Raisys, V | 1 |
| Dover, G | 1 |
| Papayannopoulou, T | 1 |
| Stamatoyannopoulos, G | 1 |
3 other studies available for valproic acid and Hemoglobinopathies
| Article | Year |
|---|---|
The effect of histone deacetylase inhibitors on AHSP expression.
Topics: Blood Proteins; Gene Expression Regulation; Hemoglobinopathies; Histone Deacetylase Inhibitors; Huma | 2018 |
Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale.
Topics: Aspirin; Blood Transfusion, Intrauterine; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 2007 |
Stimulation of fetal hemoglobin production by short chain fatty acids.
Topics: Adult; Anemia, Sickle Cell; Animals; Anticonvulsants; Butyrates; Butyric Acid; Cells, Cultured; Epil | 1995 |