valproic acid has been researched along with Hearing Loss, Sensorineural in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is an important and commonly used histone deacetylase (HDAC) inhibitor for class I (HDAC1, 2, 3, and 8) and class IIa (HDAC4, 5, 7, and 9)." | 5.91 | Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression. ( Cho, HH; Choi, YM; Lee, S; Nam, YS, 2023) |
| "Carbamazepine (CBZ) was found to be effective in most cases." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "Susac syndrome is an occlusive arteriolar disease that provokes infarcts in the cochlea, retina, and brain of young subjects, mostly women." | 2.40 | Susac syndrome. ( Aumaitre, O; Biousse, V; Bousser, MG; Fardeau, C; Godeau, P; Huong, DL; Lehoang, P; N'Guyen, N; Papo, T; Piette, JC, 1998) |
| "Valproic acid (VPA) is an important and commonly used histone deacetylase (HDAC) inhibitor for class I (HDAC1, 2, 3, and 8) and class IIa (HDAC4, 5, 7, and 9)." | 1.91 | Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression. ( Cho, HH; Choi, YM; Lee, S; Nam, YS, 2023) |
| "Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment." | 1.56 | ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020) |
| " However, this is the first case of VPA-induced hearing loss that was tested and confirmed with a VPA rechallenge, supported by serial audiometry and pharmacokinetic modelling." | 1.40 | Valproate-induced reversible sensorineural hearing loss: a case report with serial audiometry and pharmacokinetic modelling during a valproate rechallenge. ( Bakar, MZ; Lim, KS; Lo, YL; Tan, CT; Yeap, LL, 2014) |
| "These findings represent VPA-induced sensorineural hearing loss, possibly in preexisting presbycusis." | 1.28 | Sensorineural hearing loss: a reversible effect of valproic acid. ( Armon, C; Brown, E; Carwile, S; Miller, P; Shin, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nam, YS | 1 |
| Choi, YM | 1 |
| Lee, S | 1 |
| Cho, HH | 1 |
| Gasser, M | 1 |
| Boonsimma, P | 1 |
| Netbaramee, W | 1 |
| Wechapinan, T | 1 |
| Srichomthomg, C | 1 |
| Ittiwut, C | 1 |
| Krenn, M | 1 |
| Zimprich, F | 1 |
| Milenkovic, I | 1 |
| Abicht, A | 1 |
| Biskup, S | 1 |
| Roser, T | 1 |
| Shotelersuk, V | 1 |
| Tacke, M | 1 |
| Kuersten, M | 1 |
| Wagner, M | 1 |
| Borggraefe, I | 1 |
| Suphapeetiporn, K | 1 |
| von Stülpnagel, C | 1 |
| Mir, A | 1 |
| Chaudhary, M | 1 |
| Alkhaldi, H | 1 |
| Alhazmi, R | 1 |
| Albaradie, R | 1 |
| Housawi, Y | 1 |
| Chauhan, S | 1 |
| Tripathi, P | 1 |
| Goyal, P | 1 |
| Kumar, D | 1 |
| Yeap, LL | 1 |
| Lim, KS | 1 |
| Lo, YL | 1 |
| Bakar, MZ | 1 |
| Tan, CT | 1 |
| Lance, EI | 1 |
| Shapiro, BK | 1 |
| Papo, T | 1 |
| Biousse, V | 1 |
| Lehoang, P | 1 |
| Fardeau, C | 1 |
| N'Guyen, N | 1 |
| Huong, DL | 1 |
| Aumaitre, O | 1 |
| Bousser, MG | 1 |
| Godeau, P | 1 |
| Piette, JC | 1 |
| Armon, C | 1 |
| Brown, E | 1 |
| Carwile, S | 1 |
| Miller, P | 1 |
| Shin, C | 1 |
2 reviews available for valproic acid and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Susac syndrome.
Topics: Adult; Anti-Inflammatory Agents; Audiometry, Pure-Tone; Brain Diseases; Cyclophosphamide; Diagnosis, | 1998 |
6 other studies available for valproic acid and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Valproic Acid Inhibits Progressive Hereditary Hearing Loss in a KCNQ4 Variant Model through HDAC1 Suppression.
Topics: Animals; Deafness; Hair Cells, Auditory; Hearing Loss; Hearing Loss, Sensorineural; Histone Deacetyl | 2023 |
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss | 2020 |
Bipolar disorder in Pendred syndrome: a case report of two siblings.
Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Female; Goiter, Nodular; Hearing Loss, Sens | 2014 |
Valproate-induced reversible sensorineural hearing loss: a case report with serial audiometry and pharmacokinetic modelling during a valproate rechallenge.
Topics: Adult; Anticonvulsants; Audiometry; Epilepsy, Temporal Lobe; Evoked Potentials, Auditory, Brain Stem | 2014 |
Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Audiometry, Pure-Tone; Central Nervo | 2013 |
Sensorineural hearing loss: a reversible effect of valproic acid.
Topics: Aged; Audiometry; Epilepsy, Temporal Lobe; Hearing Loss, Sensorineural; Humans; Male; Phenobarbital; | 1990 |