valproic acid has been researched along with Headache Disorders in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Headache Disorders: Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among headache types, unclassifiable chronic headache segregated from all other classified headaches in terms of poor response." | 2.71 | Treatment of primary headache disorders with intravenous valproate: initial outpatient experience. ( Rybicki, LA; Stillman, MJ; Zajac, D, 2004) |
| "Treatment of chronic daily headache/transformed migraine is challenging, especially when it is complicated by overuse of analgesics, triptans, or both." | 2.70 | Intravenous valproate sodium in the treatment of daily headache. ( Karpitskiy, VV; Schwartz, TH; Sohn, RS, 2002) |
| " There were no serious adverse events." | 1.72 | Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review. ( Allen, I; Gelfand, AA; Pavitt, S; Riggins, N; Zorrilla, N, 2022) |
| "Topiramate was more likely prescribed for those with comorbid headache or migraine (incident: 335 of 1251 [26." | 1.51 | Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. ( Faught, E; Fishman, J; Kalilani, L; Kim, H; Thurman, DJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pavitt, S | 1 |
| Gelfand, AA | 1 |
| Zorrilla, N | 1 |
| Allen, I | 1 |
| Riggins, N | 1 |
| Kim, H | 1 |
| Faught, E | 1 |
| Thurman, DJ | 1 |
| Fishman, J | 1 |
| Kalilani, L | 1 |
| Lambru, G | 1 |
| Castellini, P | 1 |
| Bini, A | 1 |
| Evangelista, A | 1 |
| Manzoni, GC | 1 |
| Torelli, P | 1 |
| Friedman, BW | 1 |
| Grosberg, BM | 1 |
| Schwartz, TH | 1 |
| Karpitskiy, VV | 1 |
| Sohn, RS | 1 |
| Stillman, MJ | 1 |
| Zajac, D | 1 |
| Rybicki, LA | 1 |
| Coskun, O | 1 |
| Ucler, S | 1 |
| Cavdar, L | 1 |
| Inan, LE | 1 |
| D'Amico, D | 1 |
| Pascual, J | 1 |
| Cacabelos, P | 1 |
| Yurekli, VA | 1 |
| Akhan, G | 1 |
| Kutluhan, S | 1 |
| Uzar, E | 1 |
| Koyuncuoglu, HR | 1 |
| Gultekin, F | 1 |
| Freitag, FG | 1 |
| Diamond, S | 1 |
| Diamond, ML | 1 |
| Urban, GJ | 1 |
| Robbins, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Oxygen Therapy in Primary Headache Disorder[NCT05511155] | 132 participants (Actual) | Observational | 2022-07-01 | Completed | |||
| Therapeutic Management of Acute Cephalalgia Before and After Use of a Therapeutic Protocol in Emergency Department[NCT02236442] | 200 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Headache Disorders
| Article | Year |
|---|---|
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Antiepileptic drugs in the prophylaxis of migraine, chronic headache forms and cluster headache: a review of their efficacy and tolerability.
Topics: Anticonvulsants; Clinical Trials as Topic; Cluster Headache; Drug Resistance; Fructose; Headache Dis | 2007 |
3 trials available for valproic acid and Headache Disorders
| Article | Year |
|---|---|
Intravenous valproate sodium in the treatment of daily headache.
Topics: Adolescent; Adult; Analgesics; Cerebellar Ataxia; Chronic Disease; Dose-Response Relationship, Drug; | 2002 |
Treatment of primary headache disorders with intravenous valproate: initial outpatient experience.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Cluster Headache; Female; Headache Disorders; Humans; Infu | 2004 |
The effect of sodium valproate on chronic daily headache and its subgroups.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Double-Blind Method; Female; Headache Dis | 2008 |
7 other studies available for valproic acid and Headache Disorders
| Article | Year |
|---|---|
Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Chronic Disease; Female; GABA Agents; Headache Dis | 2022 |
Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dissociative Disorders; Epilepsi | 2019 |
Hemicrania continua evolving from cluster headache responsive to valproic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Depression; Dyspepsia; Female; GABA Agents; Gastritis; Head | 2008 |
Effect of valproic acid on withdrawal therapy in patients with overuse of chronic daily headache medications.
Topics: Adult; Aged; Analgesics; Chronic Disease; Female; GABA Agents; Headache Disorders; Humans; Male; Mid | 2007 |
More lessons for the treatment of chronic daily headache.
Topics: Adrenergic beta-Antagonists; Analgesics; Anticonvulsants; Clinical Protocols; Clinical Trials as Top | 2008 |
Divalproex in the long-term treatment of chronic daily headache.
Topics: Adult; Body Weight; Female; Headache Disorders; Humans; Male; Migraine Disorders; Retrospective Stud | 2001 |
We need better preventative medications.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Headache Disorders; Humans; Selective Serotonin R | 2001 |