valproic acid has been researched along with HbS Disease in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The fact that valproic acid, a derivative of pentanoic acid, also induces gamma-globin expression suggests that short-chain fatty acid derivatives that are already approved for human use may possess the property of gamma-globin inducibility and may be of therapeutic relevance to the beta-chain hemoglobinopathies." | 3.69 | Stimulation of fetal hemoglobin production by short chain fatty acids. ( Blau, CA; Dover, G; Fournarakis, B; Josephson, B; Li, Q; Liakopoulou, E; Papayannopoulou, T; Raisys, V; Stamatoyannopoulos, G; Wolf, JA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liakopoulou, E | 1 |
| Blau, CA | 1 |
| Li, Q | 1 |
| Josephson, B | 1 |
| Wolf, JA | 1 |
| Fournarakis, B | 1 |
| Raisys, V | 1 |
| Dover, G | 1 |
| Papayannopoulou, T | 1 |
| Stamatoyannopoulos, G | 1 |
| Selby, R | 1 |
| Nisbet-Brown, E | 1 |
| Basran, RK | 1 |
| Chang, L | 1 |
| Olivieri, NF | 1 |
2 other studies available for valproic acid and HbS Disease
| Article | Year |
|---|---|
Stimulation of fetal hemoglobin production by short chain fatty acids.
Topics: Adult; Anemia, Sickle Cell; Animals; Anticonvulsants; Butyrates; Butyric Acid; Cells, Cultured; Epil | 1995 |
Valproic acid and augmentation of fetal hemoglobin in individuals with and without sickle cell disease.
Topics: Anemia, Sickle Cell; Anticonvulsants; Antisickling Agents; Blood Transfusion; Carbamazepine; Child; | 1997 |