Page last updated: 2024-10-26

valproic acid and Hallucinations

valproic acid has been researched along with Hallucinations in 32 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations."7.78Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012)
"We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations."3.78Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012)
" The adverse effect (AE) profile of this combination needs clarification."2.69Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. ( Faught, E; French, J; Harden, C; Jacobson, M; Montouris, G; Morris, G; Rosenfeld, W, 1999)
"Abdominal migraine is a commonly described migraine variant in children and young adults, but associations with Alice in Wonderland syndrome and lilliputian hallucinations are exceptional."2.46A migraine variant with abdominal colic and Alice in Wonderland syndrome: a case report and review. ( Hamed, SA, 2010)
"To describe the dose-concentration relationship of a continuous intravenous infusion of valproic acid (VPA) in pediatric patients when a dosing protocol is used."1.34Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients. ( Baumann, RJ; Cook, AM; Farzam, F; Kuhn, RJ; Lewis, DA; Taylor, LM, 2007)
" Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased."1.32Visual hallucinations associated with zonisamide. ( Akman, CI; Goodkin, HP; Riviello, JJ; Rogers, DP, 2003)
"Right hemispheric brain tumors involving the orbitofrontal or basotemporal cortex are a rare cause of secondary mania."1.32Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. ( Denson, TF; Sokolski, KN, 2003)
"Valproic acid is infrequently used for treatment of psychosis."1.28Neuroleptic-valproic acid combination in treatment of psychotic symptoms: a three-case report. ( Bryant, S; Flack, J; Morrison, P; Wassef, A; Watson, DJ, 1989)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.25)18.7374
1990's3 (9.38)18.2507
2000's13 (40.63)29.6817
2010's13 (40.63)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Colijn, MA1
Thusius, N1
Romanowicz, M1
Mlynek, K1
Sola, C1
Alba Palé, L1
Cercós, A1
Samsó, B1
Sugranyes, G1
Giermanski, J1
Bastiampillai, T1
Gupta, A1
Ilik, F1
Ilik, K1
Budhdeo, S1
Marquette, M1
Singh, D1
Rajagopal, V1
Chauhan, S1
Tripathi, P1
Khanna, A1
Goyal, P1
Vreeburg, SA1
Leijten, FS1
Sommer, IE1
Segers, K1
Rosenzweig, I1
Valentin, A1
Brex, PA1
Elwes, RD1
Alarcon, G1
Hamed, SA1
Verrotti, A1
Coppola, G1
D'Egidio, C1
Parisi, P2
Chiarelli, F1
Belaizi, M1
Mehssani, J1
Yahyaoui, M1
Fajri, A1
Jang, JW1
Youn, YC1
Seok, JW1
Ha, SY1
Shin, HW1
Ahan, SW1
Park, KY1
Kwon, OS1
Hung, WC1
Hsieh, MH1
de Laat, SA1
Hillegers, MH1
Jansen, FE1
Braun, KP1
de Graeff-Meeder, ER1
Akman, CI1
Goodkin, HP1
Rogers, DP1
Riviello, JJ1
Majumdar, S1
Jones, NS1
McKerrow, WS1
Scadding, G1
Sokolski, KN1
Denson, TF1
Swann, AC1
Daniel, DG1
Kochan, LD1
Wozniak, PJ1
Calabrese, JR1
Ferri, R1
Pagani, J1
Cecili, M1
Montemitro, E1
Villa, MP1
Taylor, LM1
Farzam, F1
Cook, AM1
Lewis, DA1
Baumann, RJ1
Kuhn, RJ1
Roberts, CK1
Davenport, R1
Patel, HN1
Patel, NC1
Bourguignon, A1
Monfort, JC1
de Medeiros, P1
Cadet, B1
Chaneac, D1
Couper, J1
Bhatara, VS1
Carrera, J1
Faught, E1
Morris, G1
Jacobson, M1
French, J1
Harden, C1
Montouris, G1
Rosenfeld, W1
Filteau, MJ1
Leblanc, J1
Lefrançoise, S1
Demers, MF1
Hori, H1
Terao, T1
Shiraishi, Y1
Nakamura, J1
Solhkhah, R1
Finkel, J1
Hird, S1
Reeves, RR1
Mustain, DW1
Pendarvis, JE1
Wassef, A1
Watson, DJ1
Morrison, P1
Bryant, S1
Flack, J1

Reviews

3 reviews available for valproic acid and Hallucinations

ArticleYear
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
    Psychiatric genetics, 2020, Volume: 30, Issue:6

    Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety

2020
A migraine variant with abdominal colic and Alice in Wonderland syndrome: a case report and review.
    BMC neurology, 2010, Jan-06, Volume: 10

    Topics: Brain; Colic; Electroencephalography; Evoked Potentials; Hallucinations; Humans; Intestinal Diseases

2010
The management of idiopathic olfactory hallucinations: a study of two patients.
    The Laryngoscope, 2003, Volume: 113, Issue:5

    Topics: Adult; Anticonvulsants; Female; Hallucinations; Humans; Middle Aged; Phenytoin; Retrospective Studie

2003

Trials

2 trials available for valproic acid and Hallucinations

ArticleYear
Psychosis in mania: specificity of its role in severity and treatment response.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:6

    Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Cluster Analysis; Delusio

2004
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
    Epilepsia, 1999, Volume: 40, Issue:8

    Topics: Adolescent; Adult; Child; Dizziness; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combinatio

1999

Other Studies

27 other studies available for valproic acid and Hallucinations

ArticleYear
Prolonged Psychosis Associated with Left Insular Stroke: Talking to God in the Walls.
    Psychosomatics, 2018, Volume: 59, Issue:6

    Topics: Aged; Antimanic Agents; Antipsychotic Agents; Cerebral Cortex; Electroencephalography; Hallucination

2018
Childhood Visual Hallucinations: A Case Report of Idiopathic Occipital Epilepsy.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2018, Volume: 57, Issue:6

    Topics: Child; Electroencephalography; Epilepsy; Female; Hallucinations; Humans; Occipital Lobe; Psychiatric

2018
'I've got an iPod in my head'.
    The Australian and New Zealand journal of psychiatry, 2013, Volume: 47, Issue:10

    Topics: Adult; Hallucinations; Humans; Male; Treatment Outcome; Valproic Acid

2013
Alice in Wonderland syndrome as aura of migraine.
    Neurocase, 2014, Volume: 20, Issue:4

    Topics: Adolescent; Alice in Wonderland Syndrome; Anticonvulsants; Hallucinations; Humans; Male; Migraine wi

2014
Normoammonemic encephalopathy: solely valproate induced or multiple mechanisms?
    BMJ case reports, 2014, Mar-10, Volume: 2014

    Topics: Aged; Aggression; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Brain Diseases; Confusion; Delusi

2014
Valproate for management of idiopathic olfactory hallucinosis.
    The Australian and New Zealand journal of psychiatry, 2014, Volume: 48, Issue:12

    Topics: Adult; Female; GABA Agents; Hallucinations; Humans; Smell; Treatment Outcome; Valproic Acid

2014
Auditory hallucinations preceding migraine, differentiation with epileptic origin: A case report.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Epilepsy; Follow-Up Studies; Hallucinations;

2016
Charles Bonnet syndrome disappearing with carbamazepine and valproic acid but not with levetiracetam.
    Acta neurologica Belgica, 2009, Volume: 109, Issue:1

    Topics: Aged, 80 and over; Anticonvulsants; Carbamazepine; Female; Hallucinations; Humans; Levetiracetam; Pi

2009
Face-related ictal hallucinations and illusions and reflex-type phenomena.
    The Journal of neuropsychiatry and clinical neurosciences, 2009,Fall, Volume: 21, Issue:4

    Topics: Adult; Anticonvulsants; Cerebral Cortex; Electroencephalography; Epilepsy, Complex Partial; Face; Fe

2009
Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?
    Seizure, 2010, Volume: 19, Issue:6

    Topics: Anticonvulsants; Blindness; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Ethosuximide

2010
[Psychotic disorder revealing epilepsy linked to a dysembryoma of the left hippocampus].
    Revue neurologique, 2011, Volume: 167, Issue:3

    Topics: Acute Disease; Adult; Anticonvulsants; Antipsychotic Agents; Diagnosis, Differential; Electroencepha

2011
Hypermetabolism in the left thalamus and right inferior temporal area on positron emission tomography-statistical parametric mapping (PET-SPM) in a patient with Charles Bonnet syndrome resolving after treatment with valproic acid.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2011, Volume: 18, Issue:8

    Topics: Aged; Brain Mapping; Enzyme Inhibitors; Hallucinations; Humans; Male; Positron-Emission Tomography;

2011
Neutropenia associated with the comedication of quetiapine and valproate in 2 elderly patients.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:3

    Topics: Aged, 80 and over; Antimanic Agents; Antipsychotic Agents; Asian People; Bipolar Disorder; Dementia,

2012
Hallucinations after withdrawal of valproic acid.
    Pediatrics, 2012, Volume: 130, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Hallucinations; Humans; Substance Withdr

2012
Visual hallucinations associated with zonisamide.
    Pharmacotherapy, 2003, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Female; Hallucinations; Humans; Landau-Kleffner Syndrome;

2003
Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2003, Volume: 16, Issue:4

    Topics: Anticonvulsants; Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain Neoplasms; Disease Progressi

2003
Ictal video-polysomnography and EEG spectral analysis in a child with severe Panayiotopoulos syndrome.
    Epileptic disorders : international epilepsy journal with videotape, 2005, Volume: 7, Issue:4

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Eye Movements; Hallucinations;

2005
Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients.
    Pharmacotherapy, 2007, Volume: 27, Issue:4

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combinatio

2007
Hallucinations during lamotrigine treatment.
    The Nurse practitioner, 2008, Volume: 33, Issue:3

    Topics: Adolescent; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Erythema Infectiosum;

2008
[Treatment of several psychotic states with the combination of valproic acid with diazepam].
    Annales medico-psychologiques, 1984, Volume: 142, Issue:9

    Topics: Acute Disease; Adult; Delusions; Diazepam; Drug Therapy, Combination; Female; Hallucinations; Halope

1984
Unilateral musical hallucinations and all that jazz.
    The Australian and New Zealand journal of psychiatry, 1994, Volume: 28, Issue:3

    Topics: Aged; Auditory Perceptual Disorders; Cerebrovascular Disorders; Dominance, Cerebral; Drug Therapy, C

1994
Medications for aggressiveness.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1994, Volume: 33, Issue:2

    Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Clonidine; Electroencephalography; Hallu

1994
Visual and auditory hallucinations with the association of bupropion and valproate.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:2

    Topics: Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Bupropion; Hallucinations; Humans; Male; M

2000
Treatment of Charles Bonnet syndrome with valproate.
    International clinical psychopharmacology, 2000, Volume: 15, Issue:2

    Topics: Age Factors; Aged; Antimanic Agents; Female; Hallucinations; Humans; Syndrome; Treatment Outcome; Va

2000
Possible risperidone-induced visual hallucinations.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2000, Volume: 39, Issue:9

    Topics: Adolescent; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Diagnosis, Du

2000
Valproate-induced tinnitus misinterpreted as psychotic symptoms.
    Southern medical journal, 2000, Volume: 93, Issue:10

    Topics: Antimanic Agents; Bipolar Disorder; Diagnosis, Differential; Hallucinations; Humans; Male; Middle Ag

2000
Neuroleptic-valproic acid combination in treatment of psychotic symptoms: a three-case report.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1

    Topics: Adult; Antipsychotic Agents; Drug Therapy, Combination; Female; Hallucinations; Humans; Male; Middle

1989