Page last updated: 2024-10-26

valproic acid and HIV

valproic acid has been researched along with HIV in 5 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells."3.73Valproic acid does not affect markers of human immunodeficiency virus disease progression. ( Ances, BM; Buzzell, M; Ellis, RJ; Grant, I; Lazaretto, D; Letendre, S; Marcotte, TD; Marquie-Beck, J, 2006)
"Among 1345 HIV/AIDS persons in active care between 2001 and 2007, 169 individuals were exposed to AEDs for the following indications: peripheral neuropathy/neuropathic pain (60%), seizure/epilepsy (24%), mood disorder (13%) and movement disorder (2%)."1.36Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS. ( Gill, MJ; Krentz, HB; Lee, K; Maingat, F; Power, C; Siemieniuk, RA; Vivithanaporn, P, 2010)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, K1
Vivithanaporn, P1
Siemieniuk, RA1
Krentz, HB1
Maingat, F1
Gill, MJ1
Power, C1
Cohen, J1
Ances, BM1
Letendre, S1
Buzzell, M1
Marquie-Beck, J1
Lazaretto, D1
Marcotte, TD1
Grant, I1
Ellis, RJ1
Maggi, JD1
Halman, MH1
Dasgupta, A1
Wells, A1
Chow, L1

Other Studies

5 other studies available for valproic acid and HIV

ArticleYear
Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS.
    BMC neurology, 2010, Jun-17, Volume: 10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anticonvulsants; Calcium Channel Blockers; CD4 Antigens;

2010
HIV/AIDS. Report of novel treatment aimed at latent HIV raises the 'c word'.
    Science (New York, N.Y.), 2005, Aug-12, Volume: 309, Issue:5737

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Enfuvirtide; Enz

2005
Valproic acid does not affect markers of human immunodeficiency virus disease progression.
    Journal of neurovirology, 2006, Volume: 12, Issue:5

    Topics: Adult; Anticonvulsants; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Disease Progre

2006
The effect of divalproex sodium on HIV replication in vivo.
    The Journal of neuropsychiatry and clinical neurosciences, 2007,Summer, Volume: 19, Issue:3

    Topics: Adult; CD4 Lymphocyte Count; Enzyme Inhibitors; Female; HIV; HIV Infections; Humans; Male; Middle Ag

2007
Effect of heating human sera at a temperature necessary to deactivate human immunodeficiency virus on measurement of free phenytoin, free valproic acid, and free carbamazepine concentrations.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:4

    Topics: Anticonvulsants; Blood; Carbamazepine; Hemofiltration; HIV; Hot Temperature; Humans; Phenytoin; Valp

1999