valproic acid has been researched along with Granulocytic Leukemia, Chronic in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) has been used for epilepsy treatment since the 1970s." | 3.76 | Valproic acid in the complex therapy of malignant tumors. ( Eckschlager, T; Hrabeta, J; Hrebackova, J, 2010) |
| "A series of 8 patients with chronic myeloid leukemia (CML) refractory to imatinib mesylate with no access to second-generation tyrosine kinase inhibitors were treated with hydralazine and valproate in a compassionate manner." | 1.38 | Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia. ( Candelaria, M; Cervera, E; Cortes, J; Dueñas-González, A; Gonzalez-Fierro, A; Gordillo-Bastidas, D; Labardini, J; López-Navarro, O; Taja-Chayeb, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shvachko, LP | 1 |
| Zavelevich, MP | 1 |
| Gluzman, DF | 1 |
| Kravchuk, IV | 1 |
| Telegeev, GD | 1 |
| Wang, W | 1 |
| Zhang, J | 2 |
| Li, Y | 1 |
| Yang, X | 1 |
| He, Y | 1 |
| Li, T | 1 |
| Ren, F | 1 |
| Lin, R | 1 |
| Kircher, B | 1 |
| Schumacher, P | 1 |
| Petzer, A | 1 |
| Hoflehner, E | 1 |
| Haun, M | 1 |
| Wolf, AM | 1 |
| Nachbaur, D | 1 |
| Gastl, G | 1 |
| Hrebackova, J | 1 |
| Hrabeta, J | 1 |
| Eckschlager, T | 1 |
| Buchi, F | 1 |
| Pastorelli, R | 1 |
| Ferrari, G | 1 |
| Spinelli, E | 1 |
| Gozzini, A | 1 |
| Sassolini, F | 1 |
| Bosi, A | 1 |
| Tombaccini, D | 1 |
| Santini, V | 1 |
| Zhang, XZ | 1 |
| Yin, AH | 1 |
| Zhu, XY | 1 |
| Ding, Q | 1 |
| Wang, CH | 1 |
| Chen, YX | 1 |
| Cervera, E | 1 |
| Candelaria, M | 1 |
| López-Navarro, O | 1 |
| Labardini, J | 1 |
| Gonzalez-Fierro, A | 1 |
| Taja-Chayeb, L | 1 |
| Cortes, J | 1 |
| Gordillo-Bastidas, D | 1 |
| Dueñas-González, A | 1 |
| Morotti, A | 1 |
| Cilloni, D | 1 |
| Messa, F | 1 |
| Arruga, F | 1 |
| Defilippi, I | 1 |
| Carturan, S | 1 |
| Catalano, R | 1 |
| Rosso, V | 1 |
| Chiarenza, A | 1 |
| Pilatrino, C | 1 |
| Guerrasio, A | 1 |
| Taulli, R | 1 |
| Bracco, E | 1 |
| Pautasso, M | 1 |
| Baraban, D | 1 |
| Gottardi, E | 1 |
| Saglio, G | 1 |
| Cheng, H | 1 |
| Liu, Z | 1 |
| Blum, W | 1 |
| Byrd, JC | 1 |
| Klisovic, R | 1 |
| Grever, MR | 1 |
| Marcucci, G | 1 |
| Chan, KK | 1 |
9 other studies available for valproic acid and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Vitamin Е activates expression of С/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells.
Topics: Antineoplastic Agents; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Fusion Proteins, bcr- | 2018 |
Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Cycle; Cell Proliferation; Dru | 2015 |
Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; Benzamides; Case-Control Studies; Cell Line, Tumor; | 2009 |
Valproic acid in the complex therapy of malignant tumors.
Topics: Acetylation; Angiogenesis Inhibitors; Apoptosis; Azacitidine; Cell Cycle; Clinical Trials as Topic; | 2010 |
Acetylome and phosphoproteome modifications in imatinib resistant chronic myeloid leukaemia cells treated with valproic acid.
Topics: Acetylation; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm | 2011 |
Using an exon microarray to identify a global profile of gene expression and alternative splicing in K562 cells exposed to sodium valproate.
Topics: Alternative Splicing; Antineoplastic Agents; Apoptosis; Cell Survival; Exons; Flow Cytometry; Gene E | 2012 |
Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia.
Topics: Adult; Antineoplastic Agents; Benzamides; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Fo | 2012 |
Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Drug Interactions; Drug Resistance, Neoplasm; Enzyme I | 2006 |
Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Fatty Acids, Monounsaturated; Humans; Leukemia, Myelogenous, C | 2007 |