valproic acid has been researched along with Glaucoma in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to compare the effectiveness of combination therapy consisting of low-dose mitomycin C (MMC) and valproic acid (VPA) against high-dose MMC for improving the scar phenotype in minimally invasive glaucoma surgery (MIGS)." | 8.12 | Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery. ( Chu, SWL; Ibrahim, FI; Seet, LF; Teng, X; Toh, LZ; Wong, TT; Yap, ZL, 2022) |
| "This study aimed to compare the effectiveness of combination therapy consisting of low-dose mitomycin C (MMC) and valproic acid (VPA) against high-dose MMC for improving the scar phenotype in minimally invasive glaucoma surgery (MIGS)." | 4.12 | Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery. ( Chu, SWL; Ibrahim, FI; Seet, LF; Teng, X; Toh, LZ; Wong, TT; Yap, ZL, 2022) |
| "To determine the effect of valproic acid (VPA) on bleb morphology and scar characteristics in a rabbit model of minimally invasive glaucoma surgery (MIGS)." | 4.12 | Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery. ( Chu, SW; Ibrahim, FI; Seet, LF; Toh, LZ; Wong, TT; Yap, ZL, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Seet, LF | 3 |
| Yap, ZL | 2 |
| Chu, SWL | 1 |
| Toh, LZ | 3 |
| Ibrahim, FI | 2 |
| Teng, X | 1 |
| Wong, TT | 3 |
| Chu, SW | 2 |
| Mahalingam, K | 1 |
| Chaurasia, AK | 1 |
| Gowtham, L | 1 |
| Gupta, S | 1 |
| Somarajan, BI | 1 |
| Velpandian, T | 1 |
| Sihota, R | 1 |
| Gupta, V | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Tanaka, K | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Finger, SN | 1 |
| Stefanovic, B | 1 |
| Lobefalo, L | 1 |
| Rapinese, M | 1 |
| Altobelli, E | 1 |
| Di Mascio, R | 1 |
| Lattanzi, D | 1 |
| Gallenga, PE | 1 |
| Chiarelli, F | 1 |
| Verrotti, A | 1 |
1 trial available for valproic acid and Glaucoma
| Article | Year |
|---|---|
Therapeutic potential of valproic acid in advanced glaucoma: A pilot study.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Electroretinography; Female; Follow-Up Studi | 2018 |
6 other studies available for valproic acid and Glaucoma
| Article | Year |
|---|---|
Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery.
Topics: Animals; Collagen Type I, alpha 1 Chain; Glaucoma; Intraocular Pressure; Mitomycin; Rabbits; Valproi | 2022 |
Effect of valproic acid on functional bleb morphology in a rabbit model of minimally invasive surgery.
Topics: Animals; Collagen; Conjunctiva; Glaucoma; Humans; Intraocular Pressure; Minimally Invasive Surgical | 2022 |
Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma.
Topics: Amino Acid Transport System X-AG; Animals; Cell Survival; Glaucoma; Mice, Inbred C57BL; Mice, Knocko | 2015 |
Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis.
Topics: Animals; Cells, Cultured; Collagen Type I; Conjunctiva; Enzyme Inhibitors; Fibroblasts; Fibrosis; Ge | 2016 |
Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Color Vision Defects; Epilepsy; Female; Follow-Up | 2006 |
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live | 1982 |