valproic acid has been researched along with Friedreich Disease in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 29-year-old female patient with Friedreich's ataxia and partial seizures with acute liver failure during VPA treatment is reported." | 1.30 | Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. ( Hehlmann, R; Heubner, C; Holm, E; König, I; König, SA; Schenk, M; Sick, C; Weiss, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herman, D | 1 |
| Jenssen, K | 1 |
| Burnett, R | 1 |
| Soragni, E | 1 |
| Perlman, SL | 1 |
| Gottesfeld, JM | 1 |
| König, SA | 1 |
| Schenk, M | 1 |
| Sick, C | 1 |
| Holm, E | 1 |
| Heubner, C | 1 |
| Weiss, A | 1 |
| König, I | 1 |
| Hehlmann, R | 1 |
2 other studies available for valproic acid and Friedreich Disease
| Article | Year |
|---|---|
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
Topics: Acetylation; Alleles; Anilides; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme | 2006 |
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Comorbidity; Epilepsy; Fatal Outcome; Fem | 1999 |