valproic acid has been researched along with Fragile X Syndrome in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Excerpt | Relevance | Reference |
|---|---|---|
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeon, SJ | 1 |
| Kwon, H | 1 |
| Bae, HJ | 1 |
| Gonzales, EL | 1 |
| Kim, J | 1 |
| Chung, HJ | 1 |
| Kim, DH | 1 |
| Ryu, JH | 1 |
| Shin, CY | 1 |
| Torrioli, M | 1 |
| Vernacotola, S | 1 |
| Setini, C | 1 |
| Bevilacqua, F | 1 |
| Martinelli, D | 1 |
| Snape, M | 1 |
| Hutchison, JA | 1 |
| Di Raimo, FR | 1 |
| Tabolacci, E | 1 |
| Neri, G | 1 |
| Sahu, JK | 1 |
| Darling, A | 1 |
| Poo, P | 1 |
| Perez-Duenas, B | 1 |
| Campistol, J | 1 |
| Sovner, R | 1 |
1 review available for valproic acid and Fragile X Syndrome
| Article | Year |
|---|---|
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
1 trial available for valproic acid and Fragile X Syndrome
| Article | Year |
|---|---|
Treatment with valproic acid ameliorates ADHD symptoms in fragile X syndrome boys.
Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Female; Fragile X | 2010 |
3 other studies available for valproic acid and Fragile X Syndrome
| Article | Year |
|---|---|
Agmatine relieves behavioral impairments in Fragile X mice model.
Topics: Agmatine; Animals; Calcium Carbonate; Disease Models, Animal; Fragile X Mental Retardation Protein; | 2022 |
Valproic acid and ADHD symptoms in fragile X syndrome: more evidence is needed.
Topics: Attention Deficit Disorder with Hyperactivity; Electroencephalography; Female; Fragile X Syndrome; H | 2010 |
The use of valproate in the treatment of mentally retarded persons with typical and atypical bipolar disorders.
Topics: Adult; Autistic Disorder; Bipolar Disorder; Chronic Disease; Female; Follow-Up Studies; Fragile X Sy | 1989 |