valproic acid has been researched along with Folic Acid Deficiency in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 6.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| "In a survey of the red cell folate status of 200 patients with epilepsy, compared to 72 controls, we found that median red cell folate levels were reduced significantly in patients treated with phenytoin (p less than 0." | 3.67 | A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. ( Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H, 1987) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 2.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oakley, GP | 1 |
| Snaĭder, NA | 1 |
| Sychev, DA | 1 |
| Piliugina, MS | 1 |
| Dmitrenko, DV | 1 |
| Bochanova, EN | 1 |
| Shapovalova, EA | 1 |
| Kozhokaru, AB | 1 |
| Karlov, VA | 1 |
| Zhidkova, IA | 1 |
| Serkina, AV | 1 |
| Yerby, MS | 1 |
| Verrotti, A | 1 |
| Tana, M | 1 |
| Pelliccia, P | 1 |
| Chiarelli, F | 1 |
| Latini, G | 1 |
| Reynolds, EH | 2 |
| Kishi, T | 1 |
| Fujita, N | 1 |
| Eguchi, T | 1 |
| Ueda, K | 1 |
| Schwaninger, M | 1 |
| Ringleb, P | 1 |
| Winter, R | 1 |
| Kohl, B | 1 |
| Fiehn, W | 1 |
| Rieser, PA | 1 |
| Walter-Sack, I | 1 |
| Trimble, MR | 1 |
| Goggin, T | 1 |
| Gough, H | 1 |
| Bissessar, A | 1 |
| Crowley, M | 1 |
| Baker, M | 1 |
| Callaghan, N | 1 |
4 reviews available for valproic acid and Folic Acid Deficiency
| Article | Year |
|---|---|
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Recent advances on neural tube defects with special reference to Valproic Acid.
Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Defici | 2006 |
Mental effects of antiepileptic medication: a review.
Topics: Adolescent; Adult; Anticonvulsants; Attention; Barbiturates; Brain Chemistry; Carbamazepine; Child; | 1983 |
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
6 other studies available for valproic acid and Folic Acid Deficiency
| Article | Year |
|---|---|
Classifying by cause and preventing the many causes of spina bifida and anencephaly.
Topics: Anencephaly; Anticonvulsants; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Food, Fo | 2020 |
[Valproic acid pharmacogenetics in an individual approach to treatment of women of childbearing age with epilepsy].
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Fertility | 2011 |
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Dis | 2011 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe | 1997 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fema | 1987 |